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E coli

what are the non-inflammatory E coli illnesses? (do not see fecal WBCs) Enterotoxigenic (ETEC), Enteropathogenic (EPEC), Enteroaggregative (EAggEC)
E coli that cause invasive disease Enteroinvasive (EIEC), Enterohemorrhagic (EHEC)
ETEC characteristics **traveler's diarrhea** abrupt onset watery diarrhea, lasts 24 hours long after fluids replaced, Toxins
ETEC toxins Heat labile toxin- A-B toxin like cholera......Heat stable toxin- stimulates cGMP and secretes Cl- into the lumen ( osmotic diarrhea)
EPEC characteristics (no toxin) **most common in children**attach to ep cells and disrupt microvilli.. unique type III secretory system
EPEC attachment Tir receptors put in ep cell and intimin put on bacterial cell....causes actin rearrangement a pedestal emerges from the cell
EAggEC characteristics *** persistent diarrhea*** 3 stages (1. adhere to mucous, 2. enhance mucous formation, 3. cytotoxin damages cell)
Treatment for inflammatory E. coli infections replace fluids and antibiotics may help shorten duration
EIEC characteristics similar pathogenesis to Shigella (shiga toxin kills cells, lives intracellularly) watery diarrhea
EHEC characteristics ***most infect large bowel***, kidney damage from shiga toxin, Hemorrhagic colitis or hemolytic uremic syndrome
Hemolytic uremic syndrome is.... triad of symptoms...1. renal failure 2. thrombocytopenia 3. microangiopathic hemolytic anemia
diagnosis and treatment of invasive E. coli EHEC----0157:H7--inability to ferment sucrose----avoid antibioitics (may release more toxin)
listeria monocytogenes seen in..... maternal infection during pregnancy
Created by: sambone