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invasion bugs GI
| Question | Answer |
|---|---|
| infection: invasive pathogens to GI present with what? | Fecal leukocytes present, fever, blood in stoll |
| Salmonella characteristics | gram neg rod, non-lactose fermenter, produce H2S |
| Salmonella serotypes... (3) | O ag- somatic, H ag- flagella, Vi ag- capsular polysaccharide |
| Salmonella pathogenesis | sensitive to gastric acid (need large numbers for infection, Bacterial type III secretory system, survive intracellularly (in vacuoles then lyse) |
| S. enteritidis virulence | inflammatory diarrhea |
| Salmonella Typhi clinical characteristics | typhoid fever... fever, non-productive cough, skin develops rose spots |
| Salmonella typhi virulence | enters blood stream, little damage to intestine (little diarrhea), involvement with other organs |
| 3 salmonella manifestations | Enteritis, Septicemia, enteric fever |
| Salmonella Enteritis.... | most common form (6-48 hours after injection) |
| Salmonella Septicemia... | more prevalent in old young and immunocompromised |
| Salmonella Enteric Fever.... | Typhoid fever, bacteria pass through gastric cells and engulfed by macrophage, 10-14 days after ingestion, rose spots (skin lesions) |
| Salmonella on MacConkey | clear bc does NOT ferment lactose |
| Shigella characteristics... | non-motile gram neg, non-lactose fermenter, survive in CYTOPLASM, RESISTANT TO STOMACH ACIDS (few needed for infection) |
| Shigella Virulence... | type III secretion system, use host actin as rocket to propel to next cell |
| Shigella clinical features.... | dysentery, small volume stools, pain pooping, rarely enters bloodstream |
| Shigella treatment | fluids and electrolytes,, anti-diarrheal contraindicated |
| Campylobacter characteristics (leading cause of diarrheal illness in the US | gram neg curved rod, motile (flagella, can survive intracellularly in monocytes or intestinal ep. cells |
| Campylobacter Virulence | flagella, adhere, type III secretory system, inflammatory and bloody diarrhea |
| Campylobacter clinical presentation | watery stool, isolated on Campy BAP or Skirrow media, if symptoms longer then a week add antibiotics |
| Yersinia enterocolitica characterisitics | winter months, gram neg rod, invades mucous of terminal ilieum, often mistaken for appendicitis |
| Yersinia enterocolitica presentation | fever, 2-3 weeks with abdominal pain, not much diarrhea |
| Vibrio cholera characteristics... | curved gram neg rod w/ single FLAGELLA, |
| Vibrio cholera presentation,.... | voluminous watery diarrhea (rice-water), acute illness due to enterotoxin rapid loss of water (A-B toxin..A increases cAMP) |
| Vibrio cholera transmission.... | Contaminated water.... (seafood uncooked) |
| Vibrio cholera agar.... | TCBS agar |
| Vibrio parahaemolyticus characteristics | most virulent, salt loving, often found in undercooked shellfish, contaminated sushi, often seen in Japan |
Created by:
sambone
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