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CP2 Blood Proteins
Basic BP questions
| Question | Answer |
|---|---|
| What is the minimum daily requirement of first class proteins? (grams) | 40-60 grams. |
| How and in what amount are proteins excreted? | Small amounts though urea. |
| What are the 3 ways in which the rate of protein synthesis is increased? | T4, cortisol, and anabolic steroids. |
| What are the 3 way in which the rate of protein synthesis is decreased? | Protein Malnutrition, malignancies, and hot environments. |
| What is the structure classification of hemoglobin? | Chromoprotein |
| What is the structure classification of ferritin? | Metalloprotein |
| What is the structure classification of LDL, HDL, and VLDL? | Lipoprotein |
| What is the structure classification of mucin? | Glycoprotein |
| What is the structure classification of DNA and RNA? | Nucleoprotein |
| What is the solubility classification of albumin? | Water soluble |
| What is the solubility classification of globulin? | Water insoluble |
| What is the solubility classification of collagen, elastin, and keratin? | Insoluble in most common reagents. |
| What are a few functions of Blood proteins? (9 listed) | Transport, maintain osmotic balance, defense reactions, coagulation, fibrinolysis, contribution to nitrogen needs, structural components, enzymes, and hormones. |
| What structures are proteins a key building block of? (5 listed) | Muscle, enzymes, hormones, transport vehicles, and hemoglobin. |
| Proteins are the most significant factor in contributing to the ____________ within the ____________. This minimizes the extravasation of fluid. | Osmotic pressure Vascular space |
| What are the two proteins that constitute most of the protein in the body and what are they measured in? | Albumin and Globulin Total Protein |
| What is the key organ for protein metabolism? Immunoglobulins are the only exception, where are they metabolized? | Liver Lymphoreticular system |
| Where is Albumin formed? It is a measure of _________ function. | In the Liver Hepatocyte |
| What percent of the total protein is Albumin? | ~60% |
| What is the major purpose of Albumin? | maintain colloidal osmotic pressure |
| What are the 3 major constituents that Albumin transports? | Drugs, hormones, and enzymes. |
| Globulins are a key building block of what? | Antibodies |
| What is the half life of Albumin? | 15-19 days |
| About how long does it take to be able to recognize impairment of Albumin synthesis? | Sometime after 15-19 days |
| Serum Albumin and Globulin are measures of ____________. | Nutrition. |
| Patients who have protein-losing __________ and __________ have low levels of protein despite normal synthesis. | Enteropathies Uropathies |
| In collagen vascular diseases capillary permeability is increased. _________ is selectively lost into the extravascular space. Why is it lost? | Albumin. It is a much smaller than Globulin. |
| Why is the total protein level in liver diseases normal, but the ratio is shown to be bad? | The liver cannot produce proper amounts of Albumin, but the body produces more Globulin to keep the levels of TP normal. |
| Normally the Albumin:Globulin ratio is what? | Above 1.0 |
| Does the Albumin:Globulin ratio increase or decrease with Liver disease or collagen vascular disease? | Decrease |
| What is a main purpose for the continued testing of A:G ratio in patients with disease? Name a 3 diseases that this ratio would be monitored. (7 stated) | To diagnose evaluate and monitor the course of the disease. Cancer, intestinal/renal protein wasting states, immune disorders, liver dysfunction, impaired nutrition, and chronic edematous states. |
| What is a way in which the total protein fraction can be altered? Which fractions would it increase or decrease? | Prolonged application of a tourniquent. Increase both. |
| What is the normal value range for Total Protein? | 6.4-8.3 gm/dL |
| What is the normal value range for Albumin? | 3.5-5.0 gm/dL |
| What is the normal value range for Globulin? | 2.3-3.4 gm/dL |
Created by:
okeywan
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