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CP2 Blood Proteins

Basic BP questions

What is the minimum daily requirement of first class proteins? (grams) 40-60 grams.
How and in what amount are proteins excreted? Small amounts though urea.
What are the 3 ways in which the rate of protein synthesis is increased? T4, cortisol, and anabolic steroids.
What are the 3 way in which the rate of protein synthesis is decreased? Protein Malnutrition, malignancies, and hot environments.
What is the structure classification of hemoglobin? Chromoprotein
What is the structure classification of ferritin? Metalloprotein
What is the structure classification of LDL, HDL, and VLDL? Lipoprotein
What is the structure classification of mucin? Glycoprotein
What is the structure classification of DNA and RNA? Nucleoprotein
What is the solubility classification of albumin? Water soluble
What is the solubility classification of globulin? Water insoluble
What is the solubility classification of collagen, elastin, and keratin? Insoluble in most common reagents.
What are a few functions of Blood proteins? (9 listed) Transport, maintain osmotic balance, defense reactions, coagulation, fibrinolysis, contribution to nitrogen needs, structural components, enzymes, and hormones.
What structures are proteins a key building block of? (5 listed) Muscle, enzymes, hormones, transport vehicles, and hemoglobin.
Proteins are the most significant factor in contributing to the ____________ within the ____________. This minimizes the extravasation of fluid. Osmotic pressure Vascular space
What are the two proteins that constitute most of the protein in the body and what are they measured in? Albumin and Globulin Total Protein
What is the key organ for protein metabolism? Immunoglobulins are the only exception, where are they metabolized? Liver Lymphoreticular system
Where is Albumin formed? It is a measure of _________ function. In the Liver Hepatocyte
What percent of the total protein is Albumin? ~60%
What is the major purpose of Albumin? maintain colloidal osmotic pressure
What are the 3 major constituents that Albumin transports? Drugs, hormones, and enzymes.
Globulins are a key building block of what? Antibodies
What is the half life of Albumin? 15-19 days
About how long does it take to be able to recognize impairment of Albumin synthesis? Sometime after 15-19 days
Serum Albumin and Globulin are measures of ____________. Nutrition.
Patients who have protein-losing __________ and __________ have low levels of protein despite normal synthesis. Enteropathies Uropathies
In collagen vascular diseases capillary permeability is increased. _________ is selectively lost into the extravascular space. Why is it lost? Albumin. It is a much smaller than Globulin.
Why is the total protein level in liver diseases normal, but the ratio is shown to be bad? The liver cannot produce proper amounts of Albumin, but the body produces more Globulin to keep the levels of TP normal.
Normally the Albumin:Globulin ratio is what? Above 1.0
Does the Albumin:Globulin ratio increase or decrease with Liver disease or collagen vascular disease? Decrease
What is a main purpose for the continued testing of A:G ratio in patients with disease? Name a 3 diseases that this ratio would be monitored. (7 stated) To diagnose evaluate and monitor the course of the disease. Cancer, intestinal/renal protein wasting states, immune disorders, liver dysfunction, impaired nutrition, and chronic edematous states.
What is a way in which the total protein fraction can be altered? Which fractions would it increase or decrease? Prolonged application of a tourniquent. Increase both.
What is the normal value range for Total Protein? 6.4-8.3 gm/dL
What is the normal value range for Albumin? 3.5-5.0 gm/dL
What is the normal value range for Globulin? 2.3-3.4 gm/dL
Created by: okeywan
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