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Fam. Dyslipidemias

Familial Dyslipidemias

Most common familial dyslipidemia Type 2a hypercholesterolemia
Increased IDL, VLDL, chylomicrons; increased risk of atherosclerosis Type 3 hyperlipoproteinemia
Lipoprotein lipase deficiency Type 1 hyperchylomicronemia
Altered apolipoprotein C-II Type 1 hyperchylomicronemia
Pancreatitis, HSM, eruptive xanthomas, abdominal pain after fatty meals; may lead to retinal vein occlusion Type 1 hyperchylomicronemia
Increased LDL & cholesterol; increased risk of atherosclerosis Type 2a hypercholesterolemia
LDL receptor deficiency Type 2a hypercholesterolemia
Autosomal dominant; corneal arcus, tendon xanthoma, xanthelasma Type 2a hypercholesterolemia
Increased triglycerides, cholesterol, chylomicrons; no increased risk of atherosclerosis Type 1 hyperchylomicronemia
Increased VLDL & triglycerides Type 4 hypertriglyceridemia
Hepatic overproduction of VLDL; pancreatitis Type 4 hypertriglyceridemia
ApoE3/ApoE4 defect Type 3 hyperlipoproteinemia
Created by: kesselmb



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