Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.
Normal Size Small Size show me how
Normal Size Small Size show me how
hematology Ch 5 - 8
| Question | Answer |
|---|---|
| sickle cell disease is best differentiated from sickle cell trait by | electrophoresis (protein separation) |
| Painful swelling of hands and feet caused by sickle cell in the microcirculation of sickle cell infants is | dactylitis |
| a patient with sickle cell anemia may develop cardiopulmonary disease due to | increased blood viscosity |
| the hemolytic anemias are generally classified morphologically as | normocytic normochromic |
| The hemoglobin that cannot be separated from Hgb S through electrophoresis in buffer at pH 8.6 is | Hgb D pungab, Hgb G philia |
| Autosplenectomy is characteristic of | Sickle cell |
| The hemoglobin variant that is seen frequently in the southeastern population, shows a microcytic picture and migrates with Hgb C at 8.6 is | Hgb E |
| Which of the following "poikilocytes " is classically associated with hemoglobinopathies and liver disease? | target cells |
| Cholelithasis is frequent complication of patients with hereditary spherocytosis because | increased bilirubin is a frequent finding to continued hemolysis |
| Spherocytes do not function well in the splenic environment because | equilibrium is off (spherocytes have too much sodium, and the spleens environment has a low pH, low ATP, and low glucose) |
| One of the gravest clinical problems for individuals with thalassemia major is | Iron overload |
| The RBC inclusions that are composed of denatured hemoglobin are called | Heinz bodies |
| Which of the following morphological features is classic in the megaloblastic anemias | macro ovalocytes (hypersegmented nutrophils) |
| Spherocytes differ from normal cells in all of the following ways | no central pallor (less stretching, ATP disrupted, accumulate sodium @ a faster rate) |
| An appropriate M:E ratio in the case of megaloblastic anemia would be | 1:1 to 1:3 |
| Individuals with fanconi's anemia characteristically show | Structure abnormalities of the kidney, Chromosomal abnormalities, defective DNA repair, causing short stature, hyper-pigmentation on the trunk and neck, and broad nose |
| Ineffective erythropoeisis is defined as | destruction in the bone marrow of RBC precursors before they reach the peripheral circulation |
| Red cells that are resistant to malaria, rigid, and spoon shaped | Southeastern ovalocytosis |
| On electrophoresis, the majority hemoglobin for individuals with thalassemia major is | Hgb F |
| One of the least severe clinical manifestations of G6PD defenciency is | Congenital nonspherosytic hemolytic anemia (CNHA) |
| Storage iron is usually determined by the | serum ferritin (can be tested at all 3 stages) |
| Failure to thrive, bossed skull, severe anemia, and splenomegaly are all symptoms of which of the following disorders | beta thalassemia major state |
| The alpha thalassemic condition that is incompatible with life is | Barts Hydrob fetalis |
| The first stage of iron deficiency anemia is termed | stage 1: Continuum of iron depletion from the marrow |
| Which inclusion is associated with a "pitted" golf ball appearance | Hgb H |
| In adults, which of the following is the most common cause of iron deficiency anemia | external blood loss (men GI bleeding and women menses) |
Created by:
svankirk