hematology Ch 5 - 8
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| sickle cell disease is best differentiated from sickle cell trait by | electrophoresis (protein separation)
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| Painful swelling of hands and feet caused by sickle cell in the microcirculation of sickle cell infants is | dactylitis
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| a patient with sickle cell anemia may develop cardiopulmonary disease due to | increased blood viscosity
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| the hemolytic anemias are generally classified morphologically as | normocytic normochromic
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| The hemoglobin that cannot be separated from Hgb S through electrophoresis in buffer at pH 8.6 is | Hgb D pungab, Hgb G philia
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| Autosplenectomy is characteristic of | Sickle cell
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| The hemoglobin variant that is seen frequently in the southeastern population, shows a microcytic picture and migrates with Hgb C at 8.6 is | Hgb E
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| Which of the following "poikilocytes " is classically associated with hemoglobinopathies and liver disease? | target cells
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| Cholelithasis is frequent complication of patients with hereditary spherocytosis because | increased bilirubin is a frequent finding to continued hemolysis
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| Spherocytes do not function well in the splenic environment because | equilibrium is off (spherocytes have too much sodium, and the spleens environment has a low pH, low ATP, and low glucose)
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| One of the gravest clinical problems for individuals with thalassemia major is | Iron overload
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| The RBC inclusions that are composed of denatured hemoglobin are called | Heinz bodies
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| Which of the following morphological features is classic in the megaloblastic anemias | macro ovalocytes (hypersegmented nutrophils)
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| Spherocytes differ from normal cells in all of the following ways | no central pallor (less stretching, ATP disrupted, accumulate sodium @ a faster rate)
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| An appropriate M:E ratio in the case of megaloblastic anemia would be | 1:1 to 1:3
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| Individuals with fanconi's anemia characteristically show | Structure abnormalities of the kidney, Chromosomal abnormalities, defective DNA repair, causing short stature, hyper-pigmentation on the trunk and neck, and broad nose
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| Ineffective erythropoeisis is defined as | destruction in the bone marrow of RBC precursors before they reach the peripheral circulation
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| Red cells that are resistant to malaria, rigid, and spoon shaped | Southeastern ovalocytosis
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| On electrophoresis, the majority hemoglobin for individuals with thalassemia major is | Hgb F
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| One of the least severe clinical manifestations of G6PD defenciency is | Congenital nonspherosytic hemolytic anemia (CNHA)
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| Storage iron is usually determined by the | serum ferritin (can be tested at all 3 stages)
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| Failure to thrive, bossed skull, severe anemia, and splenomegaly are all symptoms of which of the following disorders | beta thalassemia major state
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| The alpha thalassemic condition that is incompatible with life is | Barts Hydrob fetalis
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| The first stage of iron deficiency anemia is termed | stage 1: Continuum of iron depletion from the marrow
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| Which inclusion is associated with a "pitted" golf ball appearance | Hgb H
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| In adults, which of the following is the most common cause of iron deficiency anemia | external blood loss (men GI bleeding and women menses)
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