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Intro to AA and stru
Intro to Amino Acids
Question | Answer |
---|---|
Non-polar, aliphatic R groups | Glycine, Alanine, Proline, Valine, Leucine, Isoleucin, Methionine |
Aromatic R groups | Phenylalanine, Tyrosine, Tryptophan |
Polar uncharged groups | Serine, Threonine, cysteine, Asparagine, Glutamine |
Positively charged R groups | Arginine, Lysine, Histidine |
Negatively charged R groups | Glutamate, Aspartate |
Name several factors disulfide bond formation depend on | # of cysteine residues, proximity effects, reactivity of SH groups, Redox state of glutathione (GSH) |
Ionic interactions | Strength or force of interactions depend on the magnitude of the charge Q, the inverse of the square of the distance between charged groups and the inverse of the dielectric constant |
What is the dielectric constant in a vacuum? Hexane? Water? | Vacuum=1, Hexane=2 and water=80. Organic solvents have relatively low dielectric constants |
What weakens the force of interaction? | Ions in solution in the vicinity of the charged residues. |
What is the isoelectric point (pI)? | The pH value at which a protein is electrically neutral. If the pH is greater than the pI, the protein will be negatively charged. |
Type I beta turn | Contains a Pro residue in position 2. More common |
Type II beta turn | Contains a Gly in position 3 |