Hematology 1 Word Scramble
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Question | Answer |
Spherocytes do not function well in the splenic environment because the: | osmotic environment of the spherocyte is impaired |
Spherocytes differ from normal cells in all the following ways: | Decreased surface-to-volume ratio, decreased central pallor, decreased resistance to hypotonic saline |
spherocytes are the same in what way to normal cells: | increased deformability |
Red cells that are rigid, provide resistance to malaria, and are spoon shaped are termed: | Ovalocytes from Southeast Asian ovalocytosis |
One of the least severe clinical manifestations of G6PD deficiency is: | Congenital non-spherocytic hemolytic anemia |
Individuals with Fanconi's anemia characteristically will have: | Increased Hgb F |
What is most closely associated with G6PD deficiency? | G6PD is a sex linked inherited disease |
The deficit of what is most closely associated with Southeast Asian ovalocytosis? | Molecular band 3 |
The inability of the red blood cell to generate ATP for membrane function is most closely associated with: | Pyruvate kinase deficiency |
Beta polypeptide chains of hemoglobin: | 2-3 months fetal into adulthood |
Gamma polypeptide chains of hemoglobin: | decreases into adulthood |
Laboratory findings in hereditary spherocytosis do NOT include: | decreased osmotic fragility |
Laboratory findings in hereditary spherocytosis include: | increased autohemolysis corrected by glucose, reticulosytosis, and shortened erythrocyte survival |
Patients with (A-) type G6PD deficiency are LEAST likely to have hemolytic episodes in which of the following situations? | Spontaneously |
The most appropriate screening test for hereditary spherocytosis is: | Osmotic fragility |
The most appropriate screening test for paroxysmal nocturnal hemoglobinuria is: | Sucrose hemolysis |
Hemolysis in paroxysmal nocturnal hemoglobinuria (PNH) is: | Caused by a red cell membrane defect |
What inclusions cannot be visualized by the Wright-stained peripheral smear? | Heinz bodies |
What functions most affect spherocytes as they travel through the circulation? | They are less deformable and more sensitive to the low glucose in the spleen. |
Many individuals with hereditary spherocytosis are prone to jaundice because of: | Gallstone disease |
What are characteristics of hereditary pyropoikilocytosis? | Elliptocytes, spherocytes, and budding red blood cells |
What red blood cell morphology is formed as a result of Heinz bodies being pitted from the red blood cell? | Bite cells |
What hemolytic disorder has red blood cells that are especially sensitive to lysis by complement? | Paroxysmal nocturnal hemoglobinuria |
In the osmotic fragility test, normal red blood cells hemolyze at which level? | 0.45% |
One of the least severe clinical manifestations of G6PD deficiency is: | Congenital nonspherocytic hemolytic anemia |
An anemia that manifests as decreased marrow cellularity, cytopenias in two cellular elements, ad a reticulocytopenia is appropriately termed: | Aplastic anemia |
Individuals with Fanconi's anemia characteristically show: | Increased Hgb F |
Created by:
Megan Hohenberg
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