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Hematology 1

Hematology in Practice - Chapter 7

Spherocytes do not function well in the splenic environment because the: osmotic environment of the spherocyte is impaired
Spherocytes differ from normal cells in all the following ways: Decreased surface-to-volume ratio, decreased central pallor, decreased resistance to hypotonic saline
spherocytes are the same in what way to normal cells: increased deformability
Red cells that are rigid, provide resistance to malaria, and are spoon shaped are termed: Ovalocytes from Southeast Asian ovalocytosis
One of the least severe clinical manifestations of G6PD deficiency is: Congenital non-spherocytic hemolytic anemia
Individuals with Fanconi's anemia characteristically will have: Increased Hgb F
What is most closely associated with G6PD deficiency? G6PD is a sex linked inherited disease
The deficit of what is most closely associated with Southeast Asian ovalocytosis? Molecular band 3
The inability of the red blood cell to generate ATP for membrane function is most closely associated with: Pyruvate kinase deficiency
Beta polypeptide chains of hemoglobin: 2-3 months fetal into adulthood
Gamma polypeptide chains of hemoglobin: decreases into adulthood
Laboratory findings in hereditary spherocytosis do NOT include: decreased osmotic fragility
Laboratory findings in hereditary spherocytosis include: increased autohemolysis corrected by glucose, reticulosytosis, and shortened erythrocyte survival
Patients with (A-) type G6PD deficiency are LEAST likely to have hemolytic episodes in which of the following situations? Spontaneously
The most appropriate screening test for hereditary spherocytosis is: Osmotic fragility
The most appropriate screening test for paroxysmal nocturnal hemoglobinuria is: Sucrose hemolysis
Hemolysis in paroxysmal nocturnal hemoglobinuria (PNH) is: Caused by a red cell membrane defect
What inclusions cannot be visualized by the Wright-stained peripheral smear? Heinz bodies
What functions most affect spherocytes as they travel through the circulation? They are less deformable and more sensitive to the low glucose in the spleen.
Many individuals with hereditary spherocytosis are prone to jaundice because of: Gallstone disease
What are characteristics of hereditary pyropoikilocytosis? Elliptocytes, spherocytes, and budding red blood cells
What red blood cell morphology is formed as a result of Heinz bodies being pitted from the red blood cell? Bite cells
What hemolytic disorder has red blood cells that are especially sensitive to lysis by complement? Paroxysmal nocturnal hemoglobinuria
In the osmotic fragility test, normal red blood cells hemolyze at which level? 0.45%
One of the least severe clinical manifestations of G6PD deficiency is: Congenital nonspherocytic hemolytic anemia
An anemia that manifests as decreased marrow cellularity, cytopenias in two cellular elements, ad a reticulocytopenia is appropriately termed: Aplastic anemia
Individuals with Fanconi's anemia characteristically show: Increased Hgb F
Created by: Megan Hohenberg