cellular bioenergetics: ATP and O2
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| study high energy bonds | in notebook
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| equation that will represent that ΔG for any reaction can be changed by changing the concentrations of reactants and/or products. | ΔG = ΔG0! + RT ln [P]/[S]
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| nucleoside monophosphokinase refers to adding a | phosphate to a NMP
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| nucleoside diphosphokinase refers to adding a | phosphate to a NDP
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| Be able to write the reaction for adenylate kinase. | ADP + ADP <__> AMP + ATP
adenylate cyclase transfers one phosphate from a ADP to another.
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| What kind of reaction is catalyzed by cytochrome P450 monooxygenase? What is oxidized and what is reduced? | RH + O2 + NADPH + H+ __> ROH + H2O + NADP+
RH and NADPH are both oxidized.
Oxygen is reduced.
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| Assume a sudden loss of oxygen supply to a cell. Give a simple scenario (sequence of events) that might lead to cell death (necrosis) and release of enzymes. | hypoxia-> dec oxidative phosphorylation (due to dec o2 which is the last E acceptor in the ETC)-> dec ATP-> dec active transport-> intracell Ca++ inc and causes cellular swelling->permeability inc (inc CK/troponin in blood) ->cell dies
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| CK in blood after hypoxia gives us estimate of | amt of cell permeability and death
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Created by:
carolanimal
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