Phys3 Clear & Transp
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Clearance | show 🗑
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What does clearance asses | show 🗑
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show | NET secretion or reabsorption
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Cx X Px = Ux X V | show 🗑
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show | Cx = (Ux X V)/Px
**Measured in ml/min, measure the VOLUME of plasma cleared per unit TIME
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If a substance is filtered and COMPLETELY reabsorbed, what is the clearance of that substance? | show 🗑
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What does it mean to be freely filtered and what are some examples of freely filtered substances? | show 🗑
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What are some examples of solutes that are not freely filtered? | show 🗑
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Why is inulin a good indicator of GFR | show 🗑
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Can a substance have a clearance that is greater than GFR? | show 🗑
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Can the clearance of a substance be used to measure RBF? | show 🗑
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substance with a clearance = RBF | show 🗑
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If GFR=Clearance | show 🗑
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If GFR < Clearance | show 🗑
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If GFR > Clearance | show 🗑
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show | Creatinine clearance. It is endogenous and is exported into the BL continuously by skeletal muscle.
**It is freely filtered and not reabsorbed (very little is secreted so it could overestimate GFR).
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show | 1.24 hr patient urine.
2.BL sample during collection time.
3.[creatinine] in both BL & urine.
4.Use clearance formlua.
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Can C(creatinine) levels give inaccurate GFR? | show 🗑
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What happens to teh GFR with aging? | show 🗑
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normal plasma value of creatinine? | show 🗑
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show | INVERSELY related.
**If GFR dramatically decreases, plasma [creatinine] Inc (GFR < 40ml/min)
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show | Low GFR leads to low urine flow, which Inc urea retention and INCREASES BUN.
**Fast flow rates will lead to decreased BUN
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using BUN to determine dehydration | show 🗑
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show | INCREASES b/c of the flow dependence of urea excretion but NOT creatinine.
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show | INCREASES it
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How does a Ded FF affect π(PTC) | show 🗑
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