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Parenteral Nutrition

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Question
Answer
What is parenteral nutrition?   show
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what are electrolytes?   show
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show -nonfunctioning GIT -need for Bowel Rest -severe malnutrition and EN not possible, or inadequate to meet needs -Patients whose nutrition needs exceed what can be met enterally -pre-operative repletion of malnourished patients  
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contraindications of Parenteral Nutrition Support   show
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PN   show
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CPN   show
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TPN   show
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PPN   show
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show defined by the position of the tip (NOT by the site of entry)  
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Components of PN   show
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Non-tunneled central line   show
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What are the 2 types of short term CPN?   show
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show -central line via peripheral access -entrance in antecubital vein -threaded into subclavian vein -catheter tip in superior vena cava  
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show -IV antibiotic therapy -Blood -Meds -Chemo  
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show -tunneled catheters -implanted ports  
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What is a tunneled catheter?   show
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How do tunneled catheters decrease risk of infection?   show
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What is an Implanted Port?   show
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show -for short-term -standard peripheral lines: site rotation every 48-72 hours -extended dwell catheters: up to 4 weeks  
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show 48-72 hours  
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show -phlebitis -phlebotomy  
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show -Monohydrate Glucose -aka Dextrose  
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how many kcals are in dextrose monohydrate?   show
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What are the typical concentrations of Dextrose stock solutions?   show
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What are the typical final dextrose concentrations?   show
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show -5 mg/kg/min -7 mg/kg/min may be tolerated in burns/trauma  
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what happens when the Maximum CHO load of typical PN solution is exceeded?   show
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What is the typical ptotein source in a PN solution?   show
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show -may vary in concentration -8.5% and 10% common  
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show 40-50%  
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What % of standard Amino Acid solutions made of Non-essential Amino Acids?   show
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show -more Essential Amino Acids -little to no Non-Essential Amino Acids  
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How are Amino Acid compositions different for PN solutions for liver failure?   show
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What kinds of lipids are found in the typical PN solution?   show
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How much Essential Fatty acids are in the typical PN solution?   show
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What is the caloric value of amino acids in TPN solution?   show
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show -8.5% -10% most common  
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What is the minimum amount of CHO needed in a TPN solution to prevent endogenous glucose production?   show
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show 10 or 20% -20% more common  
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show -10 kcal/g -additional kcal is from the glycerol backbone  
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what is the maximum amount of lipids that should be given in a TPN solution?   show
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show -fatty liver  
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show -gluconate  
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show -prevents blood clots from forming  
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What is the benefit of adding pepcid to a TPN solution?   show
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Why is iron not added to PN solutions?   show
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How are Structured Triglycerides produced?   show
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show -can bypass lymphatic system -don't require carnitine for transport into mitochondria -are rapidly oxidized  
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show 8.3 kcal/g  
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show -mostly omega-3 fatty acids -omega-6 -omega-9  
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What are the demonstrated benefits of a Structured Triglyceride PN formula compared to standard lipid emulsions?   show
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show -experimental lipid emulsion that is used in Europe, but not approved by FDA in US -80% olive oil -20% soybean oil -ClinOleic is an example  
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What are Fish Oil lipid emulsions?   show
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What is the benefit of using dipeptides containing glutamine for experimental PN solution?   show
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What is the experimental evidence of benefits of Glutamine?   show
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What is a "2-in-1" + lipids formulation?   show
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What is a "Total Nutrient Admixture" (TNA) formulation?   show
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show ~650 mOsm/L to prevent phlebitis  
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What is the result of too high of osmolarity of a peripheral infusion?   show
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What are the advantages of peripheral parenteral nutrition?   show
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show -osmolarity and volume issues -maintenance of access (standard IV)  
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show -can accomodate hypertonic solutions -better for long-term  
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What are the disadvantages of central parenteral nutrition?   show
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