Hemotology Test 3
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| What does IDA stands for? | Iron
Deficiency
Anemia
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| What is the Most Common Anemia? | Iron Deficiency Anemia
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| What are the 3 causes of IDA? | (1.)Decreased iron intake (from diet)
(2.)Increased need for iron (preganancy, lacting women, growing children)
(3.)Increase loss of iron(heavy menstruation, chronic blood loss, and Intravascular hemolytic processes)
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| What is the Pathogenesis of IDA? | It develops slowly over time.
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| Stage 1 of iron depletion | Storage iron depletion
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| Stage 2 of iron depletion | Transport iron depletion
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| Stage 3 of iron depletion | Functional iron depletion
(iron deficiency anemia)
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| Values for Stage 1 iron depletion | RDW - abnormal
Serum Ferritin - decreased
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| Effects of Stage 2 iron depletion | Deficient erythropoesis
Not enough iron to insert into Protoporphyrin ring to form heme causing zinc to bind instead
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| Values for Stage 2 iron depletion | Hgb - lower
Ferritin - still low
Serum iron - lower
TIBC - will rise
% saturation - lower
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| Values for Stage 3 iron depletion | full-blown anemia
H&H - are low
Ferritin - extremely low
Serum iron - low
TIBC - high
%saturation - low
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| What does ACD stand for? | Anemia of Chronic Disease
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| What is used to stain iron for slides? | Prussian Blue stains hemosiderin
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| What is Hemosiderin? | Storage form of iron
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| What 3 place in the body is ferritin and hemosiderin found? | Liver
Spleen
Bone Marrow
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| What would a blood slide of IDA look like? | Microcytic, hypochromic
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| What would be the CBC results for IDA? | Hbg decreased
Elevated RDW
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| What is the most common anemia for hospital patients? | Anemia of Chronic Disease
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| What are the 6 chronic diseases associated with ACD? | Rheumatoid Arthritis (RA)
Systemic Lupus Erythematosus (SLE)
Tuberculosis (TB)
Malignancies
Chronic Urinary Tract Infection
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| Which anemia is iron abundant? | ADC
Anemia of Chronic Disease
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| What is the term for low serum iron? | Sideropenia
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| What 2 reactions cause sideropenia? | increased of hepcidin and decreased EPO production
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| What is hepcidin? | inflammatory cytokines produced by hepatocytes in to regulate iron levels
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| How does hepcidin work? | it blocks the uptake in the duodenum and release from marcophages for recycling; decreasing delivery to RBC
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| Where is Erythropoietin (EPO) produced? | in the Kidneys
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Created by:
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