Diagnostic Studies for Physician Assistants
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| What are the indications for Amylase testing? | -Detect & monitor the course of pancreatitis (i.e. patient presents w/ LUQ tendernes)
-Most sensitive test for pancreatitis
-However, not specific for pancreatitis (bowel perf, peptic ulcer, duodenal obstruciton, mumps, renal failure, DKA)
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| What is the clinical significance of Amylase? | Aids in catabolism of carbs. Secreted from acinar cells -> pancreatic duct -> duodenum. If pancreatic cells are damaged, this enzyme is released into the bloodstream.
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| What can cause increased enzyme levels of Amylase? | -Damage to acinar cells (acute pancreatitis)
-Obstruction of pancreatic duct flow (Pancreatic Ca, CBD stone)
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| What is the time frame for Amylase levels? | Increased amylase level is apparent within 12 hours of acute pancreatitis. Returns to normal within 48-72 hours after onset of symptoms. However certain diseases can cause persistent elevated levels (i.e. pancreatic duct obstruction).
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| What can cause decreased Amylase levels? | Chronic pancreatitis (pancreatic cell destruction)
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| What are the indications for Lipase testing? | Evaluation of pancreatic disease
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| What is the clinical significance of Lipase? | Secreted by pancreas into duodenum to break down triglycerides into fatty acids. Increased lipase levels occur with damage to or disease affecting pancreatic acinar cells.
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| What is the time frame for Amylase levels? |
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