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lecture 26 ansari

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Question
Answer
adaptive immune system   show
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innate immune system   show
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conductor vs executor of adaptive immunity   show
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show IgE-mediated allergic rxns in a pre-sensitized host. Mast cells with specific IgE will react when they come in contact with invading Ag again, need Th2 cell help; cause asthma exacerbation, urticaria, etc from histamine release  
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atopy   show
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examples of type I hypersensitivity reactions   show
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type II hypersensitivity reactions   show
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examples of type II hypersensitivity reactions   show
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Goodpasture syndrome   show
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show mediated by deposition of immune complexes in extravascular sites or vessel walls. injury through complement activation or recruitment of neutrophils or monocytes. formation of immune complexes in the blood is not necessarily abnormal!!  
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examples of type III hypersensitivity reactions   show
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remember LUMPY-BUMPY pattern of Ab and complement deposition   show
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type IV hypersensitivity reactions   show
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examples of type IV hypersensitivity reactions   show
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systemic lupus erythematosus (SLE)   show
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screening for presence of _______ is the first step to diagnosis SLE   show
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more specific tests for definitive dx of SLE   show
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screening for presence of _______ leads to dx of Sjogren's syndrome   show
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screening for presence of _______ leads to dx of systemic sclerosis   show
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pathogenesis of SLE   show
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cause of death in many pts with lupus   show
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show lymphocytic infiltration and fibrosis of salivary glands and lacrimal glands causing chronic dry eyes and xerostomia; usually associated with other autoimmune dz like SLE or RA (secondary form); ANA usually (+)  
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show abnormal accumulation of fibrous tissue in skin and other organs, either diffuse or limited type; anti-DNA topoisomerase I antibodies (Scl-70) or anti-centromere antibodies  
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