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Lab results

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Question
Answer
CBC w/o differential   1. evaluate hematology system 2. identify blood loss (Hbg, Hct) 3. identify infection, allergy immunosuppress, or neoplasm (WBC) 4. Identify bleeding (platelet count)  
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CBC with differential   breaks down WBC: neutrophils, basophils, eosinophils, monocytes, lymphocytes  
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neutrophils   bands, "shift to the left", decreased level indicative of immunosuppressed, infection risk  
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basophils   allergic reaction  
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eosinophils   allergic reaction  
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monocytes   phagocytes, incrased in presence of bacterial infection  
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lymphocytes   T-cell: cellular type immune reaction (HIV); B-cell: antibody production  
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Chemistry 7   Na, Cl, BUN, K, CO2, Cr, and Glucose  
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Chemistry 10   Na, Cl, BUN, K, CO2, Cr, Glucose, Ca, Mg, Phos  
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Na   135-145 : cation; determinant serum osmolality.  
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Cl   95-105: anion follows Na losses and serves as a buffer in acid-base balance.  
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BUN   10-20; renal function; liver function as urea is an end product of protein metabolism.  
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K   3.5-5 cation  
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CO2   23-30; bicarbonate anion, acid-base balance.  
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Cr   0.5 - 1.2 ; use to diagnose impaired renal function.  
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Glucose   70-110 ; elevated in physiologic stress, DM, carbo food.  
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Ca   normal varies; bone synthesis; parathyroid function, renal failure, malnutrition, osteoporosis, large blood loss.  
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Mg   1.8 -2.2 ; mg deficiency, organ function esp. cardiac.  
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Phos   3.0 - 4.5 inverse with calcium, parathyroid function.  
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Coagulation Studies   PTT, aPTT, PT, INR  
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Partial thromboplastin time (PTT)   60-70 secs. measures the intrinsic system of the clotting cascade, a common pathway of clot formation. elevated: prolong cloting time(risk bleeding). Factors: I, II, V, VIII, IX, X, XI, XII  
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Activated PTT (aPTT)   30-40 sec. shorter than PTT test. with heparin, elevated mean heparin works in preventing clots. w/o heparin, elevated time indicates coagulopathy (not clotting properly) and possible impaired liver function.  
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Prothrombin Time (PT)   11 - 12.5 secs. evaluate extrinsinc factors I, II, V, VII, X. Elevate due to Coumadin, hepatocellular liver disease, obstructive biliary disease.  
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International Normalized Ratio (INR)   developed by WHO. Evaluated for therapeutic anticoagulation for DVT tx, status-post ortho sx, prevention of emboli in afib pt, mgmt of pul emboli, and prosthetic valve prophylaxis, indicator of abnormal clotting time and coagulopathy.  
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Liver Function Test (LFT)   Alk Phos, Bilirubin, AST, ALT, GGT.  
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Alkaline phosphatase (Alk Phos)   identifies liver disease and types of bone malignancies.  
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Alanine aminotransferase (ALT)   identifies hepatocellular disease.  
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Aspartate aminotransferase (AST) or (SGOT)   elevated in hepatocellular disease, cardiac injury, or skeletal muscle injury.  
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Gamma glutamyl transpeptidase (GGT)   indicator in alcohol abuse and hepatobiliary disease.  
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Bilirubin   total = sum of indirect (unconjugated) and direct (conjugated) levels; evaluates liver functions.  
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Cardiac Enzyme Markers   CK (CPK), Troponin I and T, and Myoglobin  
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Creatine Kinase (CK) (CPK)   an enzyme found in brain tissue, skeletal and heart muscle, but CK-MB(CK-Muscle & Brain) is specific to heart muscle damaage. Level rise in muscle or nerve cell injuries.  
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Troponin I and T   specific to heart muscle damage; gold standard for cardiac ischhemia, injury, and infarction.  
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Myoglobin   found in muscle damage, therefore not cardiac specific marker. Value rise in people who run marathons, suffer skeletal muscle trauma, or suffer Myocardial infarction.  
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Inflammation Markers   ESR and CRP  
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ESR - erythrocyte sedimentation rate   not specific indicator of inflammation or disease process, but help if sx is vague. use to monitor tx of illness or disease.  
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CRP - C-reactive Protein   non specific to inflmmation. elevated in the presense of bacterial infections and tissue necrosis. It appears more rapidly than ESR.  
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LIPID Panel   Cholesterol, HDL, LDL, TG  
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Cholesterol   <200 mgdL; elevated = hyperlipidemia (HLD), increasing the risk of heart disease and HTN.  
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Low-density lipoprotein (LDL)   60-180 mg/dL; bad cholesterol; High level indicates risk for heart disease  
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High-density lipoprotein (HDL)   Male: >45; female:>55; good cholesterol; remove cholesterol from tissues. low level indicates risk for heart disease  
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Triglycerides (TG)   fat in the bloodstream; High level indicates risk for heart disease  
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Serum Osmolality   285-295 mmol/kg; measures concentration of dissolved particles in blood. amt of free water inversely proportion to osmolality. H2O increase = osmolality decrease and vice versa.  
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