Biochem: Oxidative Phosphorylation
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| show | hydride ions to NAD and hydrogen atoms to FAD, FMN, Q, transported as electrons to cytochromes
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| show | tendency to gain electrons for a given redox pair
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| Negative reduction potential? | show 🗑
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| show | tendency of the oxidized partner to lose electrons increases
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| With respect to reduction potential, electrons will move? | show 🗑
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| show | ATP formed:Oxygen atom reduced
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| show | 3 ATP:1 NADH
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| P/O ratio for FADH2? | show 🗑
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| Why are 2.5 ATP synthesized for each NADH instead of three? | show 🗑
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| show | proton pumps establish a chemiosmotic gradient in which complex 1, 3 and 4 pump protons into the intermembrane space giving it a high pH and positive charge as compared to matrix. Energy generated by proton gradient drives ATP synthesis
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| What couples oxidation to phosphorylation? | show 🗑
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| show | the energy to move protons out of the matrix is smaller than the energy lost to heat, if energy of gradient is not dissipated
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| What is the Fo domain of the F1/F0 ATPase? | show 🗑
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| What is the F1 domain of the F1/F0 ATPase? | show 🗑
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| show | S and b2 subunits
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| show | when a proton is transferred the rotator stalk (gamma-epselon subunit) has a conformational change and rotates on the immobile F1 subunit, catalyzing ATP
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| show | inhibits ATP synthase by binding to the F0 domain thus closing the proton channel, electron transport is halted
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| show | lactic acidosis in the blood
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| show | uncoupling proteins:cause proton's to leak across inner mito membrane: UPC1, ionophores, 2,4-Dinitrophenol, CCCP, FCCP
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| show | Released as heat called nonshivering thermogenesis
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| show | UCP1/thermogenin causes heat production in brown fat by making a pore in the inner mito membrane and dissipating the proton gradient
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| show | ETC block
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| What is the effect of 2,4-Dinitrophenol (DNP)? | show 🗑
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| Effects of CCCP and FCCP? | show 🗑
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| What uncouplers are found naturally in the body? | show 🗑
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| What is UPC2 & UPC3 used for clinically? | show 🗑
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| Examples of ionophores | show 🗑
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| show | channel forming by dimerization to form beta-helix
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| Function of valinomycin | show 🗑
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| Function of Nigericin | show 🗑
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| show | antitransporter of ATP and ADP, symport of Pi and H+
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| show | glycoside that binds outward faceing intermembrane space portion o fthe adenine nucleotide transporter, inhibits transporter
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| show | binds the inward facing matrix portion of the adenine nucleotide transporter, inhibits transporter
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| show | inhibit ATP production/stall ETC
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| What is the function of NSAIDS on oxidative phophorylation? | show 🗑
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| show | pore formation in the outer mito membrane
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| show | complex 1, 3, 4, 5
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| show | lactic acidosis
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| What kind of inheritance is seen in ETC and oxidative phosphorylation disorders? | show 🗑
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| show | Leber's hereditary optic neuropathy (LHON), LHON Dystonia, mito encephalomyopathy-lactic acidosis-stroke like episodes (MELAS)
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| show | Leigh's Disease, myoclonic epilepsy with ragged-red fibers (MERFF), neuropathy-ataxia-and retinitis pigmentosa (NARP)
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| show | 13 of 120
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| What affects mutation rate of mito DNA? | show 🗑
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| show | maternal
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| show | abnormal proliferation of mito
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| show | bilateral loss of central vision occurs due to neuroretinal degen
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| show | Affects the brainstem and basal ganglia and is charcterised by defects in mito oxidative phosphorylation
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| show | breakdown of muscle due to injury, toxins or metabolic disease which leads to high [] of myoglobin in both plasma and urine
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| show | pathological hallmark of mtDNA disease characterized by subsarcolemmal accumulation of abnormal mito in the muscle fiber, which stain red with a Gomori trichrome stain
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Created by:
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