Quick Absite review
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each of the black spaces below before clicking
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show | Inhibits cell wall synthesis
Altered cell wall (unable to bind)
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What is the mechanism of quinolones? | show 🗑
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What is the mechanism of amphotericin | show 🗑
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Which antibiotics are bacteriocidal, with irreversible binding to 30S ribosome subunit, and resistance due to decreased active transport? | show 🗑
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show | Chromium
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show | Zinc
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What vitamin deficiency causes weakness (respiratory) and encephalopathy? | show 🗑
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What vitamin deficiency causes anemia and neutropenia? | show 🗑
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What two electrolyte abnormalities cause hyperexcitability (increased reflexes, tetany)? | show 🗑
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What phase of the cell cycle is most sensitive to radiation therapy? | show 🗑
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show | stimulates fibroblasts and chemotactic for neutrophils (too much/too long can cause fibrosis)
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show | Attracts fibroblasts and increases smooth muscle to speed matric deposition and collagen formation
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show | Portal vein posterior to CBD (on R) and hepatic artery (on L)
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What is Diabetes Insipidus? | show 🗑
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show | Increased ADH release most often by head trauma/tumors or SCLC. Oliguria, high urine osmolarity, low serum osmolarity/Na
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What three fractures are prone to compartment syndrome? | show 🗑
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What are the signs of gastrinoma? | show 🗑
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What are the symptoms of a somatostatinoma? | show 🗑
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show | diabetes
glossitis
stomatitis
necrolytic migratory erythema (presenting problem in 70%)
Rx = streptozocin/doxorubican (selectively destroy alpha cells) and octreotide (inhibits release)
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show | WDHA syndrome = watery diarrhea hypokalemia achlorydia
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What other abnormalities can a patient with a tracheoesophageal fistula have? | show 🗑
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show | Congenital abd wall defect, intrauterine rupture of umbilical cord, no associated defects, lateral (right) defect, no sac
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show | midline defect, may contain liver or other non-bowel contents, frequent anomalies, has peritoneal sac.
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show | hyperaldosteronism = 80% adenoma, 20% bilateral hyperplasia - HTN, low K, high Na
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What is Addison's disease? | show 🗑
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show | Excessive secretion of ACTH from the anterior pituitary, usually from a pituitary adenoma. Causes 70% of non-iatrogenic Cushing's syndrome.
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show | hormone disorder with high levels of cortisol - symptoms include characteristic weight gain (truncal obesity, moon face, buffalo hump), purple striae, hirsutism, polyuria, htn, insulin intolerance
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show | Bitemporal hemianopsia - vision missing in outer half of both right and left visual fields
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show | Prolactinoma - galactorrhea, irregular menses
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What type of cancer demonstrates "peripheral palisading" of nuclei and "retraction artifact" | show 🗑
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show | venous thrombosis
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What type of melanoma has the best prognosis? worst prognosis? | show 🗑
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What is MALT a precursor to? | show 🗑
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show | PTU, Propanolol, Prednisone (& other steroids) and methimazole
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What is MEN I? | show 🗑
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What is MEN IIa? | show 🗑
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show | Thyroid, adrenal, mucosal neuromas/marfan
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show | 6MP derivative, purine analog that acts as an antimetabolite, decreases DNA synthesis
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show | Calcineurin inhibitor - inhibits mRNA encoding of IL-2
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What is the mechanism of mycophenolate (cellcept)? | show 🗑
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show | Calcineurin inhibitor - blocks IL-2 expressions/production from T cells - more potent than cyclosporine
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show | blocks IL-1 from macrophages
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What is the mechanism of sirolimus (Rapamune)? | show 🗑
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show | reduces FEV1 and FRC
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What are the effects of PEEP on the lungs? | show 🗑
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show | air in lungs after normal exhalation
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What is inspiratory capacity? | show 🗑
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What is vital capacity? | show 🗑
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What are the characteristics of silvadene? | show 🗑
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show | painful, can cause acidosis due to carbonic anhydrase inhibition
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What are the characteristics of silver nitrate? | show 🗑
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show | Seizures
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What are side effects of aminoglycosides? | show 🗑
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show | produces oxygen radicals that breakup DNA
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What are side effects of metronidazole? | show 🗑
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show | Niacin - this syndrome is called Pellegra
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What vitamin deficiency causes dermatitis, hair loss, and thrombocytopenia? | show 🗑
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show | >1 = lipogenesis (overfeeding); <0.7 = ketosis and fat oxidation (starving)
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