Rickettsia...
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| Are Rickettsiae, Chlamydiae, and Mycoplasmas related taxonomically? | Nope!
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| What type of cell makes up Rickettsiae, Chlamydiae, and mycoplasmas? | Prokaryotic
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| What is the primary mode of laboratory diagnosis for rickettsia, chlamydiae, and mycoplasmas? | Serological tests
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| Is Bacteria DNA and RNA positive or 0? | +
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| Is chlamydiae RNA and DNA positive or 0? | +
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| Is Mycoplasmas RNA and DNA positive or 0? | +
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| Is rickettsiae RNA or DNA positive or 0? | +
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| Is virus RNA or DNA positive or 0? | 0
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| + or 0 for bacteria as obligate intracellular parasites? | 0
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| + or 0 for chlamydiae as obligate intracellular parasites? | +
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| + or 0 for rickettsiae as obligate intracellular parasites? | +
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| + or 0 for mycoplasmas as obligate intracellular parasites? | 0
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| + or 0 for viruses as obligate intracellular parasites? | +
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| Does bacteria have growth on cell free media? | +
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| Does chlamydiae have growth on cell free media? | 0
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| Does rickettsiae have growth on cell free media? | 0
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| Does mycoplasmas have growth on cell free media? | +
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| Does viruses have growth on cell free media? | 0
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| Are bacteria susceptible to antibacterial drugs? | +
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| Are chlamydiae susceptible to antibacterial drugs? | +
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| Are rickettsiae susceptible to antibacterial drugs? | +
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| Are mycoplasmas susceptible to antibacterial drugs? | +
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| Are viruses susceptible to antibacterial drugs? | 0
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| Do bacteria reproduce via binary fusion? | +
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| Does chlamydiae reproduce via binary fusion? | +
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| Does rickettsiae reproduce via binary fusion? | +
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| Does mycoplasmas reproduce via binary fusion? | +
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| Does viruses reproduce via binary fusion? | 0
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| Does rickettsiae stain using gram stain? | yes, but not well
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| What is the morphology of rickettsiae? | small, coccobacillary and pleomorphic
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| What kind of reproduction style does rickettsiae have? | Intracytoplasmic
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| How is rickettsiae released from an infected cell? | Bursting the cell
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| Can rickettsiae grow on agar media? | No it requires viable cells to grow
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| What kind of pathenogenesis does rickettsiae have? | predilection for endothelial cells of blood vessels
peripheral vasculitis with leakage and thrombus formation
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| What kind of stain can be used on rickettsiae? | Giemsa Stain
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| How is rickettsiae typically spread to humans? | Arthropods... except for Q fever
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| How is Rickettsiae presented normally in humans? | variable presentation, can be benign to fulminating
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| What are the prominent clinical feature of rickettsiae? | abrupt onset, fever, headache and myalgia and petechial rash,
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| What organs can be affected by rickettsiae? | heart, liver, spleen, kidneys
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| What is death due to in rickettsiae? | vascular callapse and or renal failure
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| What diseases can be born from rickettsiaceae? | epidemic typhus, murine typhus, and Rocky mountain spotted fever, Q-fever, human monocytic ehrlichiosis, human granulocytic ehrlichiosis
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| What is another name for Epidemic Typhus? | louse borne typhus
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| What is the etiological agent for Epidemic typhus? | Rickettsia prowazeki
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| What is the vector for epidemic typhus? | human body louse
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| What is the recrudescence of latent infection with no rash involve in epidemic typhus? | Brill-Zinsser disease
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| What is another name for Murine typhus? | endemic typhus
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| What is the etiological agent for murine typhus? | Rickettsia typhi
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| What is the vector involved with murine typhus? | Rat flea and cat flea
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| What is another name for Rocky Mountain spotted fever? | American spotted fever
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| What is the etiological agent for rocky mountain spotted fever? | Rickettsia rickettsii
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| What is the vector for rocky mountain spotted fever? | Ixodes species ticks
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| How many cases of rocky mountain spotted fever are reported each year in the US? | 2000
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| How many cases of rocky mountain spotted fever are reported each year in KY? | 5
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| When did Howard T. Ricketts discover rickettsiae and how it was transmitted? | 1909
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| When did Stanislaus von Prowazek first describe rickettsiae in lice? | 1913
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| What is the etiological agen for Q fever? | Coxiella burnetti
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| What vectors are associated with q-fever? | ticks, but usually dust and aerosols in humans
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| What is the etiological agent for human monocytic ehrilichiosis? | Ehrlichia chaffeensis
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| What is the vector associated with monocytic ehrlichiosis? | Amblyomma americanum
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| What is another name for amblyomma americanum? | Lone star tick
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| What is the reservoir for the lone star tick? | white tailed deer
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| What is the etiological agent for human granulocytic ehrlichiosis? | Anaplasma phagocytophilia
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| What is the vector for human granulocytic ehrlichiosis? | Ixodes scapularis
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| What is the reservoir for ixodes scapularis? | White-footed mouse
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| Where is human granulocytic ehrlichiosis normally found? | Eastern US
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| Does rickettsiae grow on artificial media? | Nope!
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| How can you cultivate Rickettsiae? | in a cell culture and embyonated eggs
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| What serological tests are normally used in the diagnosis of a rickettsial infection? | Weil-Felix agglutination
Enzyme immunoassay
Indirect immunofluorescence
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| What are the two forms of Chlamydiae? | Elementary body and Reticulate body
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| What is meant by elementary body in reference to chlamydiae? | adapted for extracellular survival
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| What is meant by reticulate body in reference to chlamydiae? | adapted for intracellular growth
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| Will chlamydiae grow on agar media? | Nope
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| What is another way to explain how chlamydiae will not grow on agar media? | Obligate intracellular microbes
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| What is the unique reproductive cycle of chlamydiae? | EB (infectious form) to host cell to RB to cell busts to EBs
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| What type of cells does chlamydiae have an affinity for? | non-ciliated epithelial cells of mucous membranes
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| What are some examples of non-ciliated epithelial cells of mucous membranes? | conjunctiva, genitourinary tract and viz
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| What diseases are related to chlamydiae? | trahoma, lymphogranuloma venerem, STI, Ornithosis, Pharyngitis, pneumonia
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| What is the etiological agent for trachoma, lymphogranuloma venereum, and the STI? | Chlamydia trachomatis
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| What is the etiological agent for Ornithosis (zoonosis)? | Chlamydophila psittaci
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| What is the etiological agent is associated with pharyngitis and pneumonia, in the chlamydiae genus? | Chlamydophila pnemoniae
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| What is chlamydiae suspected to be an etiological agen for? | atherosclerosis, arthritis, asthma, and alzheimer's
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| What is the morphology of mycoplasmas? | lack cell wal, pleomorphic
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| What what is the size of the mycoplasmas? | .3-.8 micrometers
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| Will mycoplasmas gram stain? | Nope
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| What kind of media will mycoplasmas grow on? | agar media
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| What is the colony morphology for mycoplasmas? | small minute colonies, 10-300 micro meters
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| What mycoplasmas is responsible for pneumonia? | mycoplasma pneumoniae
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| What mycoplasma is responsible for urethritis? | Ureaplasma urealyticum
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| What is the mycoplasma is a normal flora in the gu tract in healthy adults | mycoplasma hominis
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| What did the Irvinton House in richmond, KY treat? | Trachoma
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| How many hospitals in the US between 1920 to 1950 treated trachoma? | 4
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