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Rickettsia...
| Question | Answer |
|---|---|
| Are Rickettsiae, Chlamydiae, and Mycoplasmas related taxonomically? | Nope! |
| What type of cell makes up Rickettsiae, Chlamydiae, and mycoplasmas? | Prokaryotic |
| What is the primary mode of laboratory diagnosis for rickettsia, chlamydiae, and mycoplasmas? | Serological tests |
| Is Bacteria DNA and RNA positive or 0? | + |
| Is chlamydiae RNA and DNA positive or 0? | + |
| Is Mycoplasmas RNA and DNA positive or 0? | + |
| Is rickettsiae RNA or DNA positive or 0? | + |
| Is virus RNA or DNA positive or 0? | 0 |
| + or 0 for bacteria as obligate intracellular parasites? | 0 |
| + or 0 for chlamydiae as obligate intracellular parasites? | + |
| + or 0 for rickettsiae as obligate intracellular parasites? | + |
| + or 0 for mycoplasmas as obligate intracellular parasites? | 0 |
| + or 0 for viruses as obligate intracellular parasites? | + |
| Does bacteria have growth on cell free media? | + |
| Does chlamydiae have growth on cell free media? | 0 |
| Does rickettsiae have growth on cell free media? | 0 |
| Does mycoplasmas have growth on cell free media? | + |
| Does viruses have growth on cell free media? | 0 |
| Are bacteria susceptible to antibacterial drugs? | + |
| Are chlamydiae susceptible to antibacterial drugs? | + |
| Are rickettsiae susceptible to antibacterial drugs? | + |
| Are mycoplasmas susceptible to antibacterial drugs? | + |
| Are viruses susceptible to antibacterial drugs? | 0 |
| Do bacteria reproduce via binary fusion? | + |
| Does chlamydiae reproduce via binary fusion? | + |
| Does rickettsiae reproduce via binary fusion? | + |
| Does mycoplasmas reproduce via binary fusion? | + |
| Does viruses reproduce via binary fusion? | 0 |
| Does rickettsiae stain using gram stain? | yes, but not well |
| What is the morphology of rickettsiae? | small, coccobacillary and pleomorphic |
| What kind of reproduction style does rickettsiae have? | Intracytoplasmic |
| How is rickettsiae released from an infected cell? | Bursting the cell |
| Can rickettsiae grow on agar media? | No it requires viable cells to grow |
| What kind of pathenogenesis does rickettsiae have? | predilection for endothelial cells of blood vessels peripheral vasculitis with leakage and thrombus formation |
| What kind of stain can be used on rickettsiae? | Giemsa Stain |
| How is rickettsiae typically spread to humans? | Arthropods... except for Q fever |
| How is Rickettsiae presented normally in humans? | variable presentation, can be benign to fulminating |
| What are the prominent clinical feature of rickettsiae? | abrupt onset, fever, headache and myalgia and petechial rash, |
| What organs can be affected by rickettsiae? | heart, liver, spleen, kidneys |
| What is death due to in rickettsiae? | vascular callapse and or renal failure |
| What diseases can be born from rickettsiaceae? | epidemic typhus, murine typhus, and Rocky mountain spotted fever, Q-fever, human monocytic ehrlichiosis, human granulocytic ehrlichiosis |
| What is another name for Epidemic Typhus? | louse borne typhus |
| What is the etiological agent for Epidemic typhus? | Rickettsia prowazeki |
| What is the vector for epidemic typhus? | human body louse |
| What is the recrudescence of latent infection with no rash involve in epidemic typhus? | Brill-Zinsser disease |
| What is another name for Murine typhus? | endemic typhus |
| What is the etiological agent for murine typhus? | Rickettsia typhi |
| What is the vector involved with murine typhus? | Rat flea and cat flea |
| What is another name for Rocky Mountain spotted fever? | American spotted fever |
| What is the etiological agent for rocky mountain spotted fever? | Rickettsia rickettsii |
| What is the vector for rocky mountain spotted fever? | Ixodes species ticks |
| How many cases of rocky mountain spotted fever are reported each year in the US? | 2000 |
| How many cases of rocky mountain spotted fever are reported each year in KY? | 5 |
| When did Howard T. Ricketts discover rickettsiae and how it was transmitted? | 1909 |
| When did Stanislaus von Prowazek first describe rickettsiae in lice? | 1913 |
| What is the etiological agen for Q fever? | Coxiella burnetti |
| What vectors are associated with q-fever? | ticks, but usually dust and aerosols in humans |
| What is the etiological agent for human monocytic ehrilichiosis? | Ehrlichia chaffeensis |
| What is the vector associated with monocytic ehrlichiosis? | Amblyomma americanum |
| What is another name for amblyomma americanum? | Lone star tick |
| What is the reservoir for the lone star tick? | white tailed deer |
| What is the etiological agent for human granulocytic ehrlichiosis? | Anaplasma phagocytophilia |
| What is the vector for human granulocytic ehrlichiosis? | Ixodes scapularis |
| What is the reservoir for ixodes scapularis? | White-footed mouse |
| Where is human granulocytic ehrlichiosis normally found? | Eastern US |
| Does rickettsiae grow on artificial media? | Nope! |
| How can you cultivate Rickettsiae? | in a cell culture and embyonated eggs |
| What serological tests are normally used in the diagnosis of a rickettsial infection? | Weil-Felix agglutination Enzyme immunoassay Indirect immunofluorescence |
| What are the two forms of Chlamydiae? | Elementary body and Reticulate body |
| What is meant by elementary body in reference to chlamydiae? | adapted for extracellular survival |
| What is meant by reticulate body in reference to chlamydiae? | adapted for intracellular growth |
| Will chlamydiae grow on agar media? | Nope |
| What is another way to explain how chlamydiae will not grow on agar media? | Obligate intracellular microbes |
| What is the unique reproductive cycle of chlamydiae? | EB (infectious form) to host cell to RB to cell busts to EBs |
| What type of cells does chlamydiae have an affinity for? | non-ciliated epithelial cells of mucous membranes |
| What are some examples of non-ciliated epithelial cells of mucous membranes? | conjunctiva, genitourinary tract and viz |
| What diseases are related to chlamydiae? | trahoma, lymphogranuloma venerem, STI, Ornithosis, Pharyngitis, pneumonia |
| What is the etiological agent for trachoma, lymphogranuloma venereum, and the STI? | Chlamydia trachomatis |
| What is the etiological agent for Ornithosis (zoonosis)? | Chlamydophila psittaci |
| What is the etiological agent is associated with pharyngitis and pneumonia, in the chlamydiae genus? | Chlamydophila pnemoniae |
| What is chlamydiae suspected to be an etiological agen for? | atherosclerosis, arthritis, asthma, and alzheimer's |
| What is the morphology of mycoplasmas? | lack cell wal, pleomorphic |
| What what is the size of the mycoplasmas? | .3-.8 micrometers |
| Will mycoplasmas gram stain? | Nope |
| What kind of media will mycoplasmas grow on? | agar media |
| What is the colony morphology for mycoplasmas? | small minute colonies, 10-300 micro meters |
| What mycoplasmas is responsible for pneumonia? | mycoplasma pneumoniae |
| What mycoplasma is responsible for urethritis? | Ureaplasma urealyticum |
| What is the mycoplasma is a normal flora in the gu tract in healthy adults | mycoplasma hominis |
| What did the Irvinton House in richmond, KY treat? | Trachoma |
| How many hospitals in the US between 1920 to 1950 treated trachoma? | 4 |
Created by:
jnwells03
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