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Immunohematology

Quiz yourself by thinking what should be in each of the black spaces below before clicking on it to display the answer.
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Question
Answer
What is Dosage?   show
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show Kidd, Duffy, Rh and MNSsU (Kell occasionally)  
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show Enhanced (ABO, Lewis, P, Rh, Kidd); Decreased (MNSs, Duffy) Unaffected(Kell)  
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show Warm: IgG, Requires exposure to the Antigen, Causes HDN/ HTR, Clinically significant Cold: IgM, Naturally occuring, (((No HDO/ HTR's and NOT significant))) EXCEPT ABO!!!  
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show -Causes HTR or HDN - Most are warm reactive (37C or IAT) - if "Cold reactive" or RT reactive, they are most insignificant - Usually IgG (warm) vs IgM (cold) - IgM's are "naturally occurring", i.e. NOT due to transfusion/ or pregnancy  
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show A: N-acetyl galactosamine B: Galactose H: Fucose  
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what is the order of relative amounts of H antigen present on a RBC, by blood group?   show
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show A: A1, Sda B: H C: Vicea Graninea  
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What are the Big 4 types (most common) for Whites and Blacks?   show
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show Kell, Duffy, Kidd, SsU, P, Pk, Lub  
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What alleles does the Kell blood group contain? What are the frequencies for each?   show
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show Fya and Fyb, codominance Fya 65/ 10% Fyb- 83%/ 23% Fya-/fyb- rare/ 68%  
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What alleles does the Kidd system contain? What are the frequencies of each (White/ Black)?   show
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What alleles does the MNSsU system contain? What are the frequencies of each (White/ Black)?   show
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show I: 99% i: only in neonates/ newborns  
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What are the frequencies of the Lewis system?   show
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What are the frequencies of the P system?   show
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show Lua: 7.6% Lub: 99.8% Lu: Rare  
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show Kell, Duffy, Kidd, SsU, Lutheran (some)  
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Which classes of Ab are IgM?   show
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Which classes of Ab are clinicially signicant?   show
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show 7  
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show 1  
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show 18  
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show 5  
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show 19  
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show 22  
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What chromosome is the Lutheran gene on?   show
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show 1  
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show 19  
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show Kell, Duffy, Kidd (due to pregnancy or transfusion), SsU, Lub  
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Which Blood systems will agglutinate optimally at RT or below?   show
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Which Blood systems will agglutinate best at 37C?   show
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What is the reaction of each Ab to produce HDN or HTR? Kell, Duffy, Kidd, M, N, S, s, U, I, Lewis, P, Lutheran   show
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Are Blood group Ag's present on the cell at birth?   show
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Which Ab's bind complement?   show
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What is the ethnic association of the Kell system?   show
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What is the ethnic association with the Duffy system?   show
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show <1% of Blacks are negative, making it hard to find blood.  
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What is the Ethnic association with hte Lewis system?   show
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What disease is associated with the Kell system?   show
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What is always present if U is inherited?   show
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show Glycoprotein, integral to RBC membrane.  
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What is the biochemical composition of the Duffy Ag's?   show
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What is the biochemical composition of the Kidd system?   show
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show Kell system  
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show K Antigen  
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show NO  
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show No  
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show Yes  
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show M & N- A SsU- B  
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What are the structural differences between the I and i Ag's?   show
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What Ag is associated with Mycoplasma pneumoniea and cold hemagglutinin diagnosis?   show
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show i  
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show Glycolipid, a glycosyltransferase, depends on H, Se, and Le genes... often see a transition from a+b+ to a-b+  
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show production of anti-PP1Pk Ab (anti-Tja)  
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Which blood group is linked to adhesion properties and mediation of intracellular signalling?   show
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What cells are involved primarily in innate immunity?   show
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What cells are primarily involved with adaptive immunity?   show
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show Activates T helper cells, which induce inflammatory responses and fever  
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show development of mature blood cells from stem cells in the bone marrow  
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What are the factors that affect an immune response?   show
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Which antibody is associated with a primary immune response?   show
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show IgG primarily, though some IgM can be produced  
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How long is the lag phase for a primary immune response?   show
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show A substance capable of eliciting an immune response when introduced into an immunocompetent individual to whom it's foreign  
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What is an epitope?   show
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What is an immunogen?   show
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What sort of factors affect antigenicity?   show
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Of the non-ABO blood group antigens, which are most immunogenic?   show
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show Alloantibody that results from exposure to RBC Ab via pregnancy or transfusion  
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show isoagglutinins, which are naturally occuring with no evidence of RBC exposure  
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show antibody that built against the self. It can be either specific or non specific. Warm and cold forms are possible  
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show Pentamer structure; Phase of Reactivity: cold- best at 4-10C; Cannot cross placenta; Good complement activator; Not usually clinically significant, except for the ABO system; Many are naturally occuring  
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show 1,2,3,4; Most are IgG3, some 1 and 2, not often 4  
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show IgG1, IgG3, IgG4  
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What is the half life of IgG1, 2 and 4?   show
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show Structure: Monomer; Phase of reactivity: 37C; CAN cross the placenta Poor to good activator of Complement, though requires 2; USUALLY clinically siignificant  
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What type of Antibody interact with the ABO Ag's?   show
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What is the cause of most transfusion fatalities?   show
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show Not usually, except for ABO OR if they are reactive at 37  
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show Rh, Kell, Kidd, Duffy, Ss  
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show Kidd- Jka, Jkb  
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What does LMNOP and I denote?   show
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What is the term to describe a decrease in the expected increments of platelets following a transfusion?   show
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show Platelet antibodies  
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What is post transfusion purpura?   show
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show Alloantibodies are directed at antigen on platelets inherited from the father  
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