Immunohematology
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| show | When stronger agglutination is seen when a red cell antigen is expressed from homozygous genes.
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| What are the most common blood systems to show dosage? | show 🗑
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| How are Blood systems catagorized in terms of Enzymes? (i.e. Enzyme enhanced, Enzyme decreased or Enzyme unaffected)? | show 🗑
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| What is the difference between a warm and a cold antibody? | show 🗑
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| What does clinically significant refer to? | show 🗑
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| Which sugars are associated with each Antigen: A, B and H? | show 🗑
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| show | 0>A2>B>A2B>A1>A1B
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| What do each of the following Lectin's indicate? A: Dolichos biflorus B: Ulex europaeus C: Vicea graninea | show 🗑
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| What are the Big 4 types (most common) for Whites and Blacks? | show 🗑
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| show | Kell, Duffy, Kidd, SsU, P, Pk, Lub
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| show | K(9%/2%)/k(91%/ 98%)
Kpa (2.3%/ Rare)/ Kpb (100%/ 99%),
Jsa(Rare/ 20%)/ Jsb(100%/ 99%)
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| What alleles does the Duffy blood group contain? What are the frequencies of positive for each (white/black)? | show 🗑
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| show | Codominant:
Jka: 77%/ 91%
Jkb: 72%/ 43%
***negative for both is extremely rare
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| What alleles does the MNSsU system contain? What are the frequencies of each (White/ Black)? | show 🗑
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| What is the frequency of the I system? | show 🗑
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| show | Lea: 22%/ 23% (non secretory)
Leb: 72%/ 55% (secretory)
Lea-/ Leb-: 6%/ 22%
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| What are the frequencies of the P system? | show 🗑
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| What are the frequencies of the Lutheran system? | show 🗑
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| Which classes of AB are IgG? | show 🗑
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| show | M, N, I, Lewis, P, Lutheran
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| show | Kell, Duffy, Rh, Kidd, SsU
Sometimes, P and Lutheran
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| show | 7
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| What chromosome is the Duffy gene on? | show 🗑
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| What chromosome is the Kidd gene on? | show 🗑
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| show | 5
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| What chromosome is the Lewis gene on? | show 🗑
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| What chromosome is the P gene on? | show 🗑
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| show | 19
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| What chromosome is the ABO gene located on? | show 🗑
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| show | 19
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| Which Blood systems are RBC Immune? | show 🗑
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| Which Blood systems will agglutinate optimally at RT or below? | show 🗑
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| Which Blood systems will agglutinate best at 37C? | show 🗑
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| What is the reaction of each Ab to produce HDN or HTR? Kell, Duffy, Kidd, M, N, S, s, U, I, Lewis, P, Lutheran | show 🗑
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| Are Blood group Ag's present on the cell at birth? | show 🗑
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| show | Kell, Kidd, I, Lewis, P
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| What is the ethnic association of the Kell system? | show 🗑
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| show | 68% of blacks are Fya-Fyb-. This allows them a resistance to Plasmodium vivax infection
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| What is the ethnic association of the U system? | show 🗑
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| What is the Ethnic association with hte Lewis system? | show 🗑
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| show | McLeod disease- Chronic granulomatous disease
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| What is always present if U is inherited? | show 🗑
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| show | Glycoprotein, integral to RBC membrane.
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| show | Glycoprotein that spans RBC lipid bilayer
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| show | Single protein band, part of the urea transit system.
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| show | Kell system
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| What is the strongly immunogenic component of the Kell system? | show 🗑
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| show | NO
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| show | No
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| show | Yes
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| What are the Blood group Ag's that are associated with the Glycophorins (A and B)? | show 🗑
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| What are the structural differences between the I and i Ag's? | show 🗑
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| What Ag is associated with Mycoplasma pneumoniea and cold hemagglutinin diagnosis? | show 🗑
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| show | i
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| What is the biochemical composition of the Lewis group Ag's? | show 🗑
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| show | production of anti-PP1Pk Ab (anti-Tja)
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| show | Lutheran
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| show | Phagocytic cells
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| What cells are primarily involved with adaptive immunity? | show 🗑
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| show | Activates T helper cells, which induce inflammatory responses and fever
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| What is hematopoiesis? | show 🗑
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| What are the factors that affect an immune response? | show 🗑
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| Which antibody is associated with a primary immune response? | show 🗑
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| Which antibody is associated with a secondary immune response? | show 🗑
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| show | 5-7 days
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| show | A substance capable of eliciting an immune response when introduced into an immunocompetent individual to whom it's foreign
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| show | A single antigenic determinent or the structural sites on the antigen to which the antibody attaches
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| What is an immunogen? | show 🗑
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| show | Route of administration, dosage, antigen density, Chemical composition(proteins most, then carbs, with lipids generally inert), complexity, size, degree of foreignness
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| Of the non-ABO blood group antigens, which are most immunogenic? | show 🗑
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| Define RBC immune immunogloblulin. | show 🗑
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| Define non RBCimmune immunogloblulin | show 🗑
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| show | antibody that built against the self. It can be either specific or non specific. Warm and cold forms are possible
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| What are the common characteristics of an IgM antibody? | show 🗑
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| What are the subclasses of IgG? | show 🗑
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| show | IgG1, IgG3, IgG4
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| show | 23 days, longer than other immunogloblulins
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| show | Structure: Monomer;
Phase of reactivity: 37C;
CAN cross the placenta
Poor to good activator of Complement, though requires 2;
USUALLY clinically siignificant
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| show | IgM, though sometimes IgG can be directed depending on the angtigen
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| show | ABO incompatibility
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| Are IgM's clinically significant? | show 🗑
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| Which Antigen groups create IgG Antibodies? | show 🗑
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| show | Kidd- Jka, Jkb
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| show | the IgM Antibodies of ABO, Ii, Lewis, MN, and P
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| What is the term to describe a decrease in the expected increments of platelets following a transfusion? | show 🗑
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| show | Platelet antibodies
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| What is post transfusion purpura? | show 🗑
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| Why do neonates get thrombocytopenia? | show 🗑
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Ring the Bell
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