overview of coag
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| primary hemostasis | vasoconstriction, plt adhesion to exposed subendothelial connective tissue. plt aggregation to form initial plug at injury site.
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| secondary hemostasis | coag factors interact on plt surface to produce fibrin. fibrin stabilization by factor XIII
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| fibrinolysis | release of tissue plasminogen activator. conversion of plasminogen to plasmin. conversion of fibrin to fdp's
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| Factors that require Vit K | II, VII, IX, X
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| Factors consumed during clotting | I,II, V, VIII, XIII
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| Labile Factors | V, VIII
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| Factors afffected by coumadin | II, VII, IX, X
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| Extrinsic pathway factors | (PT) III, VII
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| Intrinsic pathway factors | (PTT)VIII,IX, XI, XII, PK, HMWK
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| Common pathway factors | I, II, V, X
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| I | Fibrinogen, common pathway, in plasma and adsorbed plasma, treat with cryo
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| II | prothrombin, common pathway, VitK required, in plasma, treat with FFP
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| III | Tissue thromboplastin, extrinsic pathway
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| IV | Ca2+, intrinsic, extrinsic and common
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| V | Labile factor,common pathway, in plasma and adsborbed plasma, treat with FFP
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| VII | stable factor, extrinsic pathway,VitK required, in plasma and serum, treat with plasma or prothrombin complex
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| VIII | antihemophilic factor, intrinsic pathway, in plasma and absorbed plasma. Deficiency- Hemophilia A
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| IX | Christmas factor, intrinsic pathway, VitK required, in plasma and serum. Deficiency- hemophilia B
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| X | Stuart Prower, common pathway, VitK required, in plasma and serum
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| XI | plasma thromboplastic antecedent, intrinsic pathway, in plasma, adsorbed plasma and serum. Deficiency-Hemophilia C, treat with FFP
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| XII | Hageman Factor, intrinsic pathway, in plasma, adsorbed plasma and serum
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| XIII | Fibrin stabalizing factor
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| Factor VIII deficiency | Hemophilia A, treat with cryo, Factor VIII concentrate, DDAVP, sex linked recessive, primarily in males
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| vWf deficiency | treat with cryo or DDAVP
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| Liver disease affects what factors | Mild: II, VII, IX, XMod: II, V, VII, VIII, IX, XSev: I, II, V, VII, VIII, IX, X
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| VitK deficiency affects what factors | II, VII, IX, X
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| Coumadin therapy affects what factors | II, VII, IX, X
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| DIC affects what factors | I,II, V, VIII, platelets
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| Primary fibrinolyis affects what factors | I, V, VIII
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| Factors I, II, V and X have what PT/PTT results when one is deficient? | Prolonged PT and prolonged PTT
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| Factor VII deficiency PT/PTT results | prolonged PT, normal PTT
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| VIII, IX,XI, XII have what PT/PTT results with one is deficient? | Normal PT, Prolonged PTT
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| Hemophilia A | decreased VIII, PTT prolonged, PT-N, BT-N, plt count-N
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| Hemophilia B | PTT prolonged, PT-N, BT-N, plt count-N
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| Von Willebrand's Disease | BT-prolonged, PTT-prolonged, PT-N, plt count-N, abnormal plt agg with ristocetin, decreased Factor VIII
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| Glanzmann's Thrombasthenia | clot retraction abnormal, BT-abnorm, plt count-norm, plt agg abnorm with ADP, collagen, thrombin and epi
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| Bernard-Soulier syndrome | BT-prolonged, Giant plt's, Plt count decreased, clot retraction-N
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| DIC | PT/PTT-prolonged, dec Fbg, dec plts, FSP present, positive d-dimer, decreased AT-III, schistocytes present
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| Primary Fibrinolysis | prolonged PT/PTT, dec fbg, N-plt, FSP present, neg d-dimer, Norm AT-III and rbc morp
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