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Hemostasis-
overview of coag
| Question | Answer |
|---|---|
| primary hemostasis | vasoconstriction, plt adhesion to exposed subendothelial connective tissue. plt aggregation to form initial plug at injury site. |
| secondary hemostasis | coag factors interact on plt surface to produce fibrin. fibrin stabilization by factor XIII |
| fibrinolysis | release of tissue plasminogen activator. conversion of plasminogen to plasmin. conversion of fibrin to fdp's |
| Factors that require Vit K | II, VII, IX, X |
| Factors consumed during clotting | I,II, V, VIII, XIII |
| Labile Factors | V, VIII |
| Factors afffected by coumadin | II, VII, IX, X |
| Extrinsic pathway factors | (PT) III, VII |
| Intrinsic pathway factors | (PTT)VIII,IX, XI, XII, PK, HMWK |
| Common pathway factors | I, II, V, X |
| I | Fibrinogen, common pathway, in plasma and adsorbed plasma, treat with cryo |
| II | prothrombin, common pathway, VitK required, in plasma, treat with FFP |
| III | Tissue thromboplastin, extrinsic pathway |
| IV | Ca2+, intrinsic, extrinsic and common |
| V | Labile factor,common pathway, in plasma and adsborbed plasma, treat with FFP |
| VII | stable factor, extrinsic pathway,VitK required, in plasma and serum, treat with plasma or prothrombin complex |
| VIII | antihemophilic factor, intrinsic pathway, in plasma and absorbed plasma. Deficiency- Hemophilia A |
| IX | Christmas factor, intrinsic pathway, VitK required, in plasma and serum. Deficiency- hemophilia B |
| X | Stuart Prower, common pathway, VitK required, in plasma and serum |
| XI | plasma thromboplastic antecedent, intrinsic pathway, in plasma, adsorbed plasma and serum. Deficiency-Hemophilia C, treat with FFP |
| XII | Hageman Factor, intrinsic pathway, in plasma, adsorbed plasma and serum |
| XIII | Fibrin stabalizing factor |
| Factor VIII deficiency | Hemophilia A, treat with cryo, Factor VIII concentrate, DDAVP, sex linked recessive, primarily in males |
| vWf deficiency | treat with cryo or DDAVP |
| Liver disease affects what factors | Mild: II, VII, IX, XMod: II, V, VII, VIII, IX, XSev: I, II, V, VII, VIII, IX, X |
| VitK deficiency affects what factors | II, VII, IX, X |
| Coumadin therapy affects what factors | II, VII, IX, X |
| DIC affects what factors | I,II, V, VIII, platelets |
| Primary fibrinolyis affects what factors | I, V, VIII |
| Factors I, II, V and X have what PT/PTT results when one is deficient? | Prolonged PT and prolonged PTT |
| Factor VII deficiency PT/PTT results | prolonged PT, normal PTT |
| VIII, IX,XI, XII have what PT/PTT results with one is deficient? | Normal PT, Prolonged PTT |
| Hemophilia A | decreased VIII, PTT prolonged, PT-N, BT-N, plt count-N |
| Hemophilia B | PTT prolonged, PT-N, BT-N, plt count-N |
| Von Willebrand's Disease | BT-prolonged, PTT-prolonged, PT-N, plt count-N, abnormal plt agg with ristocetin, decreased Factor VIII |
| Glanzmann's Thrombasthenia | clot retraction abnormal, BT-abnorm, plt count-norm, plt agg abnorm with ADP, collagen, thrombin and epi |
| Bernard-Soulier syndrome | BT-prolonged, Giant plt's, Plt count decreased, clot retraction-N |
| DIC | PT/PTT-prolonged, dec Fbg, dec plts, FSP present, positive d-dimer, decreased AT-III, schistocytes present |
| Primary Fibrinolysis | prolonged PT/PTT, dec fbg, N-plt, FSP present, neg d-dimer, Norm AT-III and rbc morp |
Created by:
mnuesmeyer
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