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overview of coag

primary hemostasis vasoconstriction, plt adhesion to exposed subendothelial connective tissue. plt aggregation to form initial plug at injury site.
secondary hemostasis coag factors interact on plt surface to produce fibrin. fibrin stabilization by factor XIII
fibrinolysis release of tissue plasminogen activator. conversion of plasminogen to plasmin. conversion of fibrin to fdp's
Factors that require Vit K II, VII, IX, X
Factors consumed during clotting I,II, V, VIII, XIII
Labile Factors V, VIII
Factors afffected by coumadin II, VII, IX, X
Extrinsic pathway factors (PT) III, VII
Intrinsic pathway factors (PTT)VIII,IX, XI, XII, PK, HMWK
Common pathway factors I, II, V, X
I Fibrinogen, common pathway, in plasma and adsorbed plasma, treat with cryo
II prothrombin, common pathway, VitK required, in plasma, treat with FFP
III Tissue thromboplastin, extrinsic pathway
IV Ca2+, intrinsic, extrinsic and common
V Labile factor,common pathway, in plasma and adsborbed plasma, treat with FFP
VII stable factor, extrinsic pathway,VitK required, in plasma and serum, treat with plasma or prothrombin complex
VIII antihemophilic factor, intrinsic pathway, in plasma and absorbed plasma. Deficiency- Hemophilia A
IX Christmas factor, intrinsic pathway, VitK required, in plasma and serum. Deficiency- hemophilia B
X Stuart Prower, common pathway, VitK required, in plasma and serum
XI plasma thromboplastic antecedent, intrinsic pathway, in plasma, adsorbed plasma and serum. Deficiency-Hemophilia C, treat with FFP
XII Hageman Factor, intrinsic pathway, in plasma, adsorbed plasma and serum
XIII Fibrin stabalizing factor
Factor VIII deficiency Hemophilia A, treat with cryo, Factor VIII concentrate, DDAVP, sex linked recessive, primarily in males
vWf deficiency treat with cryo or DDAVP
Liver disease affects what factors Mild: II, VII, IX, XMod: II, V, VII, VIII, IX, XSev: I, II, V, VII, VIII, IX, X
VitK deficiency affects what factors II, VII, IX, X
Coumadin therapy affects what factors II, VII, IX, X
DIC affects what factors I,II, V, VIII, platelets
Primary fibrinolyis affects what factors I, V, VIII
Factors I, II, V and X have what PT/PTT results when one is deficient? Prolonged PT and prolonged PTT
Factor VII deficiency PT/PTT results prolonged PT, normal PTT
VIII, IX,XI, XII have what PT/PTT results with one is deficient? Normal PT, Prolonged PTT
Hemophilia A decreased VIII, PTT prolonged, PT-N, BT-N, plt count-N
Hemophilia B PTT prolonged, PT-N, BT-N, plt count-N
Von Willebrand's Disease BT-prolonged, PTT-prolonged, PT-N, plt count-N, abnormal plt agg with ristocetin, decreased Factor VIII
Glanzmann's Thrombasthenia clot retraction abnormal, BT-abnorm, plt count-norm, plt agg abnorm with ADP, collagen, thrombin and epi
Bernard-Soulier syndrome BT-prolonged, Giant plt's, Plt count decreased, clot retraction-N
DIC PT/PTT-prolonged, dec Fbg, dec plts, FSP present, positive d-dimer, decreased AT-III, schistocytes present
Primary Fibrinolysis prolonged PT/PTT, dec fbg, N-plt, FSP present, neg d-dimer, Norm AT-III and rbc morp
Created by: mnuesmeyer