AML,
Quiz yourself by thinking what should be in
each of the black spaces below before clicking
on it to display the answer.
Help!
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| M0 | Myeloblast without cell differentiation
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| M1 | Myeloblast with minimal differentiation, some pros present; auer rods
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| M2 | Myeloblast with maturation, auer rods
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| M3 | Promyelocyte, blasts and myelocytes present, auer rods common, high incidence of DIC; t( 15; 17)
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| M4 | Myeloblast and Monoblast; peroxidase/Sudan Black positive, specific esterase positive, non-specific esterase positive
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| M5 | Monoblast
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| M6 | Erythrocytic series
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| M7 | Mekakaryocyte, CD42, CD61
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| RA | Refractory anemia with <5% blasts
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| RARS | Refractory anemia with sideroblasts and <5% blasts with ring sideroblasts
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| RAEB | Refractory anemia with excess blasts, 5-20% blasts
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| RAEBIT | Refractory anemia with excess blasts in transformation, 20-30% blasts
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| Hodgkin Lymphoma | Reed sternberg cells, bi-modal incidence, predictable( step-wise)
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| Non-Hodgkin Lymphoma | no reed sternberg cells, No pattern, unpredicatable spreading
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| ALL-L1 | small lymphoblasts
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| ALL-L2 | large and small lymphoblasts
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| ALL-L3 | large lymphoblasts with vacuoles, Burkitt lymphoma
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| CLL | mature lymphocytes, smudge cells
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| Gaucher's Disease | Glucocerebroside accumulation
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| Niemann-Pick | Sphingomyelin accumulation; sea-blue histiocytes
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| Tay-Sachs | Sphingolipids, GM2 Ganglioside accumulation
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| Hurler, Hunter | Mucopolysaccharie accumulation
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| CGD | X-linked, ineffective killing of bacteria
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| Alder-Reilly | Large azurophilic granules, increased mucopolysaccharides (Hurler,Hunter)
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| Chediak-Higashi | large lysosomes, fusion of primary granules, seen in Albinism
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| May-Hegglin | large platelets, decreased # of platelets, Dohle bodies in segs, monos and lymphs
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| Pelger-Huet | Hyposegmented polys
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| Hgb A | 2 alpha, 2 beta; 10-40% in newborn, 97% in adult
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| Hgb A2 | 2 alpha, 2 delta; <2% in newborn, 2% in adult
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| Hgb F | 2 alpha, 2 gamma; 60-90% in newborns, 1% in adult
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| Howell-Jolly Body | DNA, wright stain, indicates HA, megaloblastic anemia, post-splenectomy
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| Basophilic stippling | RNA, wright and new-methylene blue stain, seen in thalassmeia and lead poisoning
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| Pappenheimer bodies | Siderotic granules, Iron, Wright and Prussian blue, seen in sideroblastic anemia, hemogolobinopathies
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| Heinz Bodies | Denatured precipitated hemoglobin, supravital stain, G6PD deficiency, thalassemia
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| Cabot rings | remnants of mitotic spindle, wright stain, megaloblastic anemia
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| pH 8.6 electrophoresis | A2, S, F, A
(A2, C, E, Oarab, Charlem)
(S, D, G, L)
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| pH 6.2 electrophoresis | F, A, Origin, S, C
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| % retics | # retics in 1000 rbc's/ 10
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| Absolute Retic | # RBCs x % retics
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| CRC | % retics x patients Hct/ 45
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| RPI | CRC/ mat time(usually 2)
>2= adequate BM response
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| Beta Thalassemia Minor | microcytic, hypochromic; >90% A, 3.5-7% A2, F may be slightly increased
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| Beta Thalassemia Major | microcytic, hypochromic; little or no A, up to 98% F
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| Sickle Cell Anemia (SS) | >80% S, 1-20% F, 2-4.5% A2, no A
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| Sickle Cell Trait (AS) | 50-65% A, 35-45% S, normal F, normal to slightly increased A2
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