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Heme-

AML,

QuestionAnswer
M0 Myeloblast without cell differentiation
M1 Myeloblast with minimal differentiation, some pros present; auer rods
M2 Myeloblast with maturation, auer rods
M3 Promyelocyte, blasts and myelocytes present, auer rods common, high incidence of DIC; t( 15; 17)
M4 Myeloblast and Monoblast; peroxidase/Sudan Black positive, specific esterase positive, non-specific esterase positive
M5 Monoblast
M6 Erythrocytic series
M7 Mekakaryocyte, CD42, CD61
RA Refractory anemia with <5% blasts
RARS Refractory anemia with sideroblasts and <5% blasts with ring sideroblasts
RAEB Refractory anemia with excess blasts, 5-20% blasts
RAEBIT Refractory anemia with excess blasts in transformation, 20-30% blasts
Hodgkin Lymphoma Reed sternberg cells, bi-modal incidence, predictable( step-wise)
Non-Hodgkin Lymphoma no reed sternberg cells, No pattern, unpredicatable spreading
ALL-L1 small lymphoblasts
ALL-L2 large and small lymphoblasts
ALL-L3 large lymphoblasts with vacuoles, Burkitt lymphoma
CLL mature lymphocytes, smudge cells
Gaucher's Disease Glucocerebroside accumulation
Niemann-Pick Sphingomyelin accumulation; sea-blue histiocytes
Tay-Sachs Sphingolipids, GM2 Ganglioside accumulation
Hurler, Hunter Mucopolysaccharie accumulation
CGD X-linked, ineffective killing of bacteria
Alder-Reilly Large azurophilic granules, increased mucopolysaccharides (Hurler,Hunter)
Chediak-Higashi large lysosomes, fusion of primary granules, seen in Albinism
May-Hegglin large platelets, decreased # of platelets, Dohle bodies in segs, monos and lymphs
Pelger-Huet Hyposegmented polys
Hgb A 2 alpha, 2 beta; 10-40% in newborn, 97% in adult
Hgb A2 2 alpha, 2 delta; <2% in newborn, 2% in adult
Hgb F 2 alpha, 2 gamma; 60-90% in newborns, 1% in adult
Howell-Jolly Body DNA, wright stain, indicates HA, megaloblastic anemia, post-splenectomy
Basophilic stippling RNA, wright and new-methylene blue stain, seen in thalassmeia and lead poisoning
Pappenheimer bodies Siderotic granules, Iron, Wright and Prussian blue, seen in sideroblastic anemia, hemogolobinopathies
Heinz Bodies Denatured precipitated hemoglobin, supravital stain, G6PD deficiency, thalassemia
Cabot rings remnants of mitotic spindle, wright stain, megaloblastic anemia
pH 8.6 electrophoresis A2, S, F, A (A2, C, E, Oarab, Charlem) (S, D, G, L)
pH 6.2 electrophoresis F, A, Origin, S, C
% retics # retics in 1000 rbc's/ 10
Absolute Retic # RBCs x % retics
CRC % retics x patients Hct/ 45
RPI CRC/ mat time(usually 2) >2= adequate BM response
Beta Thalassemia Minor microcytic, hypochromic; >90% A, 3.5-7% A2, F may be slightly increased
Beta Thalassemia Major microcytic, hypochromic; little or no A, up to 98% F
Sickle Cell Anemia (SS) >80% S, 1-20% F, 2-4.5% A2, no A
Sickle Cell Trait (AS) 50-65% A, 35-45% S, normal F, normal to slightly increased A2
Created by: mnuesmeyer