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Heme-
AML,
| Question | Answer |
|---|---|
| M0 | Myeloblast without cell differentiation |
| M1 | Myeloblast with minimal differentiation, some pros present; auer rods |
| M2 | Myeloblast with maturation, auer rods |
| M3 | Promyelocyte, blasts and myelocytes present, auer rods common, high incidence of DIC; t( 15; 17) |
| M4 | Myeloblast and Monoblast; peroxidase/Sudan Black positive, specific esterase positive, non-specific esterase positive |
| M5 | Monoblast |
| M6 | Erythrocytic series |
| M7 | Mekakaryocyte, CD42, CD61 |
| RA | Refractory anemia with <5% blasts |
| RARS | Refractory anemia with sideroblasts and <5% blasts with ring sideroblasts |
| RAEB | Refractory anemia with excess blasts, 5-20% blasts |
| RAEBIT | Refractory anemia with excess blasts in transformation, 20-30% blasts |
| Hodgkin Lymphoma | Reed sternberg cells, bi-modal incidence, predictable( step-wise) |
| Non-Hodgkin Lymphoma | no reed sternberg cells, No pattern, unpredicatable spreading |
| ALL-L1 | small lymphoblasts |
| ALL-L2 | large and small lymphoblasts |
| ALL-L3 | large lymphoblasts with vacuoles, Burkitt lymphoma |
| CLL | mature lymphocytes, smudge cells |
| Gaucher's Disease | Glucocerebroside accumulation |
| Niemann-Pick | Sphingomyelin accumulation; sea-blue histiocytes |
| Tay-Sachs | Sphingolipids, GM2 Ganglioside accumulation |
| Hurler, Hunter | Mucopolysaccharie accumulation |
| CGD | X-linked, ineffective killing of bacteria |
| Alder-Reilly | Large azurophilic granules, increased mucopolysaccharides (Hurler,Hunter) |
| Chediak-Higashi | large lysosomes, fusion of primary granules, seen in Albinism |
| May-Hegglin | large platelets, decreased # of platelets, Dohle bodies in segs, monos and lymphs |
| Pelger-Huet | Hyposegmented polys |
| Hgb A | 2 alpha, 2 beta; 10-40% in newborn, 97% in adult |
| Hgb A2 | 2 alpha, 2 delta; <2% in newborn, 2% in adult |
| Hgb F | 2 alpha, 2 gamma; 60-90% in newborns, 1% in adult |
| Howell-Jolly Body | DNA, wright stain, indicates HA, megaloblastic anemia, post-splenectomy |
| Basophilic stippling | RNA, wright and new-methylene blue stain, seen in thalassmeia and lead poisoning |
| Pappenheimer bodies | Siderotic granules, Iron, Wright and Prussian blue, seen in sideroblastic anemia, hemogolobinopathies |
| Heinz Bodies | Denatured precipitated hemoglobin, supravital stain, G6PD deficiency, thalassemia |
| Cabot rings | remnants of mitotic spindle, wright stain, megaloblastic anemia |
| pH 8.6 electrophoresis | A2, S, F, A (A2, C, E, Oarab, Charlem) (S, D, G, L) |
| pH 6.2 electrophoresis | F, A, Origin, S, C |
| % retics | # retics in 1000 rbc's/ 10 |
| Absolute Retic | # RBCs x % retics |
| CRC | % retics x patients Hct/ 45 |
| RPI | CRC/ mat time(usually 2) >2= adequate BM response |
| Beta Thalassemia Minor | microcytic, hypochromic; >90% A, 3.5-7% A2, F may be slightly increased |
| Beta Thalassemia Major | microcytic, hypochromic; little or no A, up to 98% F |
| Sickle Cell Anemia (SS) | >80% S, 1-20% F, 2-4.5% A2, no A |
| Sickle Cell Trait (AS) | 50-65% A, 35-45% S, normal F, normal to slightly increased A2 |
Created by:
mnuesmeyer
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