#2 BOC MLT HEMATOLOGY QUESTIONS
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show | ACUTE MYELOCYTIC LEUKEMIA
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The following results were obtained on a 45 year old man complaining of chills and fever: WBC:23.0X10 LAP:200 Philadelphia Chromosome:negative Toxic granulation, Dohle bodies and vacuoles | show 🗑
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show | b. lymphocytes
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show | B lymphocytes
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show | T lymphocytes
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show | b. cytomegalovirus infection
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show | c. myelogenous leukemia
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show | Chronic myelocytic leukemia
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167) In chronic myelocytic leukemia, blood histamine concentrations tend to reflect the : a. number of platelets present b. serum uric acid concentrations c. number of basophils present d. the total number of granulocytes | show 🗑
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168) Biochemical abnormalities characteristic of polycythemia vera include: a. increased serum B12 binding capacity b. hypouricemia c. hypohistaminemia d. decreased leukocyte alkaline phosphatase activity | show 🗑
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170) 50% - 90% myeloblasts in a peripheral blood smear is typical of which of the following? a. chronic myelocytic leukemia b. myelofibrosis with myeloid metaplasia c. erythroleukemia d. acute myelocytic leukemia | show 🗑
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show | b. high
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show | d. lysozymuria
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show | d. abnormal platelet function
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show | a. phlebotomy
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185) A patient has been treated for polycythemia vera for several yrs. His blood smear now shows: Oval macrocytes Howell-Jolly bodies Hypersegmented neutrophil Large, agranular platelets the most probable cause of this blood picture is: | show 🗑
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186) In infectious mono, lymphocytes tend to be: a. small with little cytoplasm b. normal c. decreased in number d. enlarged and indented by surrounding structures | show 🗑
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show | d. are morphologically more variable throughout the smear
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191) Which of the following is true of acute lymphoblastic leukemia? a. occurs most commonly in children 1 -2 yrs. old b. patient is asymptomatic c. massive accumulation of primitive lymphoid-appearing cells in bone marrow occurs d. children under 1 y | show 🗑
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193) The most common form of childhood leukemia: a. acute lymphocytic b. acute granulocytic c. acute monocytic d. chronic granulocytic | show 🗑
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show | d. accumulation of monoclonal B cells with a block in cell maturation
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show | d. increased resistance to infection
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show | a.Gaucher Cells
(Identification of condition with morphologic alteration in neutrophils, representing giant fused lysosomes.)
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202) Which of the following anomalies is an autosomal dominant disorder characterized by irregularly-sized inclusions in polymorphonuclear neutrophils, abnormal giant platelets and often thrombocytopenia? | show 🗑
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show | PELGER-HUET anomaly
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204) Which of the following cell types is characteristic of Pelger-Huet anomaly: a. band form b. pince-nez form c. normal neutrophil d. myelocyte | show 🗑
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show | a. membrane defect of lysosomes
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206) Which of the following is associated with Alder-Reilly inclusions? a. membrane defect of lysosomes b. Dohle bodies and giant platelets c. chronic myelogenous leukemia d. mucopolysaccharidosis | show 🗑
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207) Which of the following is associated with May-Hegglin anomaly? a. membrane defect of lysosomes b. Dohle bodies and giant platelets c. chronic myelogenous leukemia d. mucopolysaccharides | show 🗑
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208) A differential was performed on an asymptomatic patient. The differential included 60% neutrophils, 55 of which had 2 lobes and 5 had 3 lobes. There were no other abnormalities. This is consistent with which of the following anomalies? a. Pelger-Hue | show 🗑
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show | b. lysosomes
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show | d. Alder-Reilly
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show | a. Gauchers disease
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show | c. May-Hegglin
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217) In synovial fluid , the most characteristic microscopic finding in gout is: a. calcium pyrophosphate crystals b. cartilage debris c. monosodium urate crystals d. hemosiderin laden macrophages | show 🗑
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show | a.(number of cells counted x dilution x 10)/number of squares counted
(Hemacytometer calculation .)
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227) A mean cell hemoglobin concentration over 36 g/dL is frequently found in : a. hereditary spherocytosis b. lipemia c. active cold agglutinin disease d. all of the above | show 🗑
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show | a. an elevated hematocrit
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show | a. granulocytic leukemoid reaction
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237) The most characteristic morphologic features of atypical lymphs include: a. course nuclear chromatin and basophilic cytoplasm b. blue-grey cytoplasm, fine nuclear chromatin c. nucleoli and deep blue RNA-rich cytoplasm d. a stretched nucleus and c | show 🗑
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show | a. calcium pyrophosphate dihydrate crystals
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show | d. hemosiderin laden macrophages
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250) Which of the following stains in closely associated with the lysosomal enzyme in primary granules? a. peroxidase b. Sudan black B c. periodic acid-Schiff d. Prussian blue | show 🗑
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show | a. volume
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257) In flow cytometric analysis, right angle of side scatter of a laser light beam provides information that pertains to the cell's: a. volume b. viability c. granularity d. lineage | show 🗑
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262) vWF antigen can be found in which of the following? a. myeloblast b. monoblast c. lymphoblast d. megakaryoblast | show 🗑
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263) Which of the following is characteristic of cellular changes as megakaryoblasts mature into megakaryocytes within the bone marrow? a. progressive decrease in overall cell size b. increasing basophilia of cytoplasm c. nuclear division without cytop | show 🗑
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show | C. Histocyte(Macrophages)
(Bone marrow and splenic macrophages contain hemosiderin; histiocyte is a collective term for macrophages.)
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show | a. megakaryocyte
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show | b. 10 days
(Average life span of platelets in peripheral blood is 9.5 days.)
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269) Platelet activity is affected by: a. calcium b. aspirin c. hyperglycemia d. hypoglycemia | show 🗑
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270) Cells involved in hemostasis are: a. erythrocytes b. granulocytes c. lymphocytes d. thrombocytes | show 🗑
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show | a. elevated
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show | c. mucous membrane hemorrhages
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show | a (Giant platelets, abnormal bleeding time, normal aggregation with ADP, decreased platelet count are characteristic of Bernard-Soulier.)
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show | A
a. allows direct visualization of the particles being counted
b. has a high degree of precision
c. has a high degree of reproducibility
d. is the method of choice for the performance of 50 - 60 counts per day
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290) An automated platelet count indicates platelet clumping, which is confirmed by examining the smear. The technician should: | show 🗑
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294) A bleeding time is used to evaluate the activity of: a. platelets b. prothrombin c. labile factor d. Factor VIII | show 🗑
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show | a. platelet count
**b. template bleeding time
c. prothrombin time
d. activated partial thromboplastin time
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297) Which of the following detects or measures platelet function? a. bleeding time b. prothrombin time c. thrombin time d. partial thromboplastin time | show 🗑
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298) Platelet aggregation is dependent in vitro on the presence of: a. calcium ions b. sodium citrate c. thrombin d. potassium | show 🗑
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show | c. II, VII, IX and X
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show | a. there are 2 sources of Vit. K: vegetables and bacterial
b. Vit. K converts precursor molecules into functional coagulation factors
c. heparin inhibits the action of Vit. K
d. Vit. K is fat soluble
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307) Which of the following is Vitamin-K dependent? a. Factor XII b. fibrinogen c. antithrombin III d. Factor VII | show 🗑
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309) Hageman Factor (XII) is involved in each of the following reactions except: a. activation of C1 to C1 esterase b. activation of plasminogen c. activation of Factor XI d. transformation of fibrinogen to fibrin | show 🗑
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310) Prothrombin is: a. a protein formed by the liver in the presence of Vitamin K b. an enzyme that converts fibrinogen into fibrin threads c. the end product of the reaction between fibrinogen and thrombin d. a protein released by platelets during c | show 🗑
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show | b. V
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show | a. kallikrein
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314) Which of the following is characteristic of Factor XII deficiency. a. negative bleeding history b. normal clotting times c. decreased risk of thrombosis d. epistaxis | show 🗑
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313) Which of the following factor deficiencies is associated with either no bleeding or only a minor bleeding tendency, even after trauma or surgery? a. Factor X b. Factor XII c. Factor XIII d. Factor V | show 🗑
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315) The 2 factors that differentiate liver disease from Vit. K deficiency are: a. II and VII b. IX and VII c. VIII and IX d. V and VII | show 🗑
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show | b. Factor VIII
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317) A patient has a normal prothrombin time and a prolonged activated partial thromboplastin time using a kaolin activator. The APTT corrects to normal when the incubation time is increased. These suggest that the patient has: a. hemophilia A b. Hagema | show 🗑
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show | a. a female carrier
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326) Plasma from a patient with lupus coagulation inhibitor can show: a. prolonged APTT and normal PT b. prolonged thrombin timer c. no change with platelet neutralization d. complete correction when incubated with normal plasma | show 🗑
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332) Acute DIC is characterized by: a. hypofibrinogenemia b. thrombocytosis c. negative D-dimer d. shortened thrombin time | show 🗑
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show | d. Ca++ and thromboplastin
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show | c. phospholipid and calcium
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show | d. monitors heparin therapy
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show | a. protein C level
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342) A prolonged thrombin time and a normal reptilase-R time are characteristic of : a. dysfibrinogenemia b. increased D-Dimer c. fibrin monomer-split product complexed d. therapeutic heparinization | show 🗑
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344) The best test to determine if a sample is contaminated with heparin is: a. fibrinogen b. thrombin time c. prothrombin time d. stypven time | show 🗑
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345) In the Clauss fibrinogen method, the time to clot formation in plasma is measured after the addition of: a. calcium b. thrombin c. phospholipids d. kaolin | show 🗑
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346) If a patient presents with a prolonged APTT that does not correct upon mixing, the next test performed should be: a. Factor II b. DRVVT c. Factor VIII d. platelet count | show 🗑
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347) Excess D-Dimer indicate that clots have been: a. converted to fibrin monomers b. released into circulation c. formed and are being excessively lysed d. stimulated to activate platelets | show 🗑
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show | a. cross-linked and stabilized fibrin clot
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show | a. activated clotting time
(The ACT monitors high dose heparin therapy at clinics, bedside, cardiac catheterization or at a surgical suite
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show | b. clot solubility in a 5 molar urea solution
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352) Heparin acts by: a. precipitating fibrinogen b. binding calcium c. activating plasma d. inhibiting thrombin | show 🗑
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353) Low molecular weight heparin is monitored by a: a. anti-Xa assay b. APTT c. PT d. anti-IIa assay | show 🗑
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354) In an automated cell counter the WBC printed result is "+++" The next step is to: a. repeat after warming the sample to 37 C b. make an appropriate dilution of the sample c. recalibrate the machine from pooled samples d. request a new sample imme | show 🗑
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show | c. review the stained blood smear
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show | b. a conductive liquid
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show | c. decreased MCH
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360) On setting up the electronic particle counter in the morning, one of the controls is slightly below the range for the MCV. Which of the following is indicated? b. adjust the MCV up slightly c. shut down the instrument d. repeat the control | show 🗑
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show | b. decreased hematocrit
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show | b. inadequate mixing of the sample prior to testing
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show | c. plantar surface of the heel
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377) When evaluating a smear for a retic count, the tech observes that the RBC's are overlapping throughout the entire slide. The most likely explanation is: | show 🗑
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show | b. crenated
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show | b. reduced in volume
a tube with a reduced volume of anticoagulant is need when the Hct is > 55%.)
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show | a. increased Hct and MCV
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show | a. EDTA
(High-quality blood smears can be made from the EDTA tube within 2-3 hours of collecting the specimen.)
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show | ***a. many platelets are abnormally large
b. blood sample is hemolyzed
c. white cell fragments are present in the blood'
d. red cell fragments are present in the blood
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383) When platelets concentrate at the edges and feathered end of a blood smear, it is usually due to: a. abnormal proteins b. inadequate mixing of blood and anticoagulant c. hemorrhage d. poorly made wedge smear | show 🗑
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show | a. examine the slide for clumping
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386) The anticoagulant of choice for routine coagulation procedures is: a. sodium oxalate b. sodium citrate c. heparin d. sodium fluoride | show 🗑
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show | d. falsely prolonged
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show | d. sensitivity
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394) On Monday a patient's Hgb determination was 11.3 g/dL and on Tuesday it measured 11.8 g/dL. The standard deviation of the method used is +/- 0.2 g/dL. Which of the following can be concluded about the Hgb values given? | show 🗑
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29) A patient is admitted with a history of chronic bleeding secondary to peptic ulcer. Hematology workup reveals a severe microcytic, hypochromic anemia. Iron studies were requested. Which of the following would be expected in this case? | show 🗑
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show | decreased serum iron
decreased transferrin saturation
decreased/normal TIBC
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62) A 14-year-old boy is seen in the ER complaining of a sore throat swollen glands and fatigue. The CBC results are: What is the most likely diagnosis? | show 🗑
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show | a. acute surgical bleeder
b. specimen on day 19 from wrong patient
c. improperly mixed specimen on day 19
***d. lipid interference on days 17 and 18
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108) What is the MCH if the Hct is 20%, the RBC is 2.4 x 10^6/mL (2.4 x 10^12/L) and the Hgb is 5 g/dL (50 g/L)? a. 21 mm3 (21 fL) b. 23 mm3 (23 fL) c. 25 mm3 (25 fL) d. 84 mm3 (84 fL) | show 🗑
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109) What is the MCH if the Hct is 20%, the is 1.5 x 10^6/mL (1.5 x 10^12/L) and the Hgb is 6 g/dL (60 g/L)? a. 28 mm3 (28 fL) b. 30 mm3 (30 fL) c. 40 mm3 (40 fL) d. 75 mm3 (75 fL) | show 🗑
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show | b. 25%
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show | b. 30%
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show | d. 77 mm3 (77 fL
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show | b. 83 pg
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show | d. 133 pg
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show | (Iron deficiency anemia laboratory features include: decreased RBC, hemoglobin, MCV, MCH, MCHC, serum iron, serum ferritin % saturation, bone marrow iron stores; and increased RDW, TIBC, FEP and serum soluble transferrin receptor levels
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154) Which of the following cells is the atypical lymphocyte seen on the peripheral blood smear of patients with infectious mononucleosis? a. T lymphocytes b. B lymphocytes c. monocytes d. mast cells | show 🗑
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180) The following results were obtained on a 55-year-old man complaining of headaches and blurred vision: These results are consistent with: | show 🗑
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show | Which of the following complications is this patient most likely to have?
***a. acute lymphocytic leukemia
b. acute myelocytic leukemia
c. acute myelomonocytic leukemia
d. busulfan toxicity
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221) If a WBC count is performed on a 1:10 dilution and the number of cells counted in 8 squares is 120, the total WBC count is: a. 1,200/mL (1.2 x 10^9/L) b. 1,500/mL (1.5 x 10^9/L) c. 12,000/mL (12.0 x 10^9/L) d. 15,000 /mL (15.0 x 10^9/L) | show 🗑
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show | b. 6,250/mL (6.25 x 10^9/L)
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show | a. 7,500/mL (7.5 x 10^9/L)
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224) A total leukocyte count is 10.0 x 10^3/mL (10.0 x 10^9/L) and 25 NRBCs are seen per 100 leukocytes on the differential. What is the corrected leukocyte count? a. 2,000/mL (2.0 x 10^9/L) b. 8,000/mL (8.0 x 10^9/L) c. 10,000/mL (10.0 x 10^9/L) d. 1 | show 🗑
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