SCHC hematology II
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| What is the normal plt count range? | show 🗑
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| List some important molecules for coagulation. | show 🗑
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| show | It's a major humoral component that causes platelet proliferation. It also regulates the production and release of plt.
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| show | They have a receptor mpl(CD110) which can bind to the megakaryotcye and circulating platelets.
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| Where are megakaryocytes located in the bone marrow? | show 🗑
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| Where are most of the platelets in the body? | show 🗑
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| show | The spleen (~1/3)
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| What's the average lifespan of a plt? | show 🗑
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| What portion of the megakaryocye is platelets composed of? | show 🗑
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| What is the demarcation membrane system? | show 🗑
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| When plts are decreased, how much TPO is present compared to normal and what does it bind to? | show 🗑
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| show | Activation, adhesion, aggregation.
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| show | Glycocalyx, phospholipid bilayer, Integral proteins.
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| Structural zone contains? | show 🗑
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| What's the purpose of the structural zone? | show 🗑
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| What disease does the sugar H2O test for? | show 🗑
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| show | Spherocytes, they lyse faster than normal RBC's in hypotonic solns
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| show | To see if there is an inflammatory process taking place, multiple myeloma, PID, Lupus, RA, kidney disease.
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| What is the normal reference range for sed rate? | show 🗑
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| show | C-reactive protein
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| show | By tissue damage which releases Ca+, or by release of tissue thromboplastin.
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| show | VII and III (Tissue Factor/TF)
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| show | X, V, II, I
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| Which factors are unique to the intrinsic pathway? | show 🗑
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| Which pathway uses the aPTT test and which medication can be monitored by this test? | show 🗑
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| Which test is commonly used to measure the extrinsic pathway? Which medication? Are there other tests routinely performed simultaneously? | show 🗑
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| show | It prevents the cleavage of fibrinogen into fibrin.
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| How does aspirin work? | show 🗑
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| show | Fxn= storage and secretion; contains granules, mitochondria, and glycogen.
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| show | Dense bodies--> non-protein mediators (i.e. ATP, ADP, serotonin)
Alpha granules--> protein mediators
Lysosomes-->Enzymes
peroxisomes--> lipid metabolism.
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| show | Open canalicular system (Secretion of granule contents) and dense tubular systems (storage of Ca+).
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| show | vasoconstriction, activation, adhesion, aggregation, fibrin formation, fibrinolysis.
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| show | ADP, thromboxane A2, aracodonic acid, von Willebrand, epinephrine, collagen
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| What causes the fibrinolysis pathway? | show 🗑
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| Inhibitors of the the fibrinolytic pathway? | show 🗑
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| show | hct/RBC x 10
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| show | hgb/rbc x 10
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| How do you calculate MCHC? | show 🗑
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| show | II, VII, IX, X, protein c, protein s , protein z. Vitamin K dependent.
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| What is the principle of the Sysmex? | show 🗑
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| What is the principle of the Beckman-Coulter analyzer? | show 🗑
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| show | Volume--> impedance
Conductivity-->electromagnetic probe
Scatter--> helium neon laser
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| Name the dense body contents and their role in platelet function. | show 🗑
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| What is a thrombus? | show 🗑
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| Why do you need to stop taking aspirin products within 10 days of surgery? | show 🗑
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| What is the reference range for WBC's in an adult? | show 🗑
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| show | Time of day, exercise, pregnancy, infection, age, race, gender, stress.
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| What do CSFs do? | show 🗑
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| show | histaminase, collagenase, and lactoferrin (pinkish colored)
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| Azurophillic (Primary) granules contain what? | show 🗑
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| Where are the granulocyte pools? | show 🗑
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| show | proliferation, maturation, Storage.
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| show | Myeloloid
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| What is the first identifiable granulocytic stage? | show 🗑
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