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Ch 17: Disease and Reistance

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Question
Answer
Active immunity   the immune system responds to antigen by producing antibodies and specific lymphocytes  
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Acute period   The phase of disease in which specific symptoms occur and the disease is at its height  
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Antibody   a highly specific protein produced by the body in response to a foreign substance  
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Antibody-mediated immunity   the form of acquired immunity conferred to an individual through the activity of B cells and the production of antibodies  
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Antigen   a substance that stimulates an immune response  
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Antigen binding site   the region on antibody that binds to an antigen  
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Antigenic determinant   a section of an antigen molecule that binds to the antibody binding site and stimulates an immune response  
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Epitope   a section of an antigen molecule that binds to the antibody binding site and stimulates an immune response  
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Antitoxin   an antibody produced by the body that circulates in the blood stream to provide protection against toxins by neutralizing them  
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Avirulent   referring to an organism that is not likely to cause disease  
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Biological vector   an infected arthropod that transmits disease-causing organisms between hosts  
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B lymphocyte   a white blood cell that matures into memory cells and plasma cells that secrete antibody  
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Carrier   an individual that has recovered from a disease but retains and continues to shed the infectious agent  
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Cell mediated immunity   the body’s ability to resist infection through the activity of T-lymphocyte recognition of antigen peptides presented on macrophages and dendritic cells and on infected cells  
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Commensalism   a close an permanent association between two species of organisms in which one species benefits and the other remains unharmed or unaffected  
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Cytotoxic T cells   The type of T-lymphocyte that searches out and destroys infected cells  
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Diagnosis   the process of identifying a disease, illness or problem by examining an individual  
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Direct contact   the form of disease transmission involving close association between hosts  
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Droplet   an airborne particle of mucus and sputum from the respiratory tract that contains disease-causing microorganisms  
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Endemic   referring to a constant presence of disease or persistence of an infectious agent at low levels in a population  
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Endotoxin   a metabolic poison, produced chiefly by gram-negative bacteria that are part of the bacterial cell wall, composed of lipid-polysaccharide-protein complexes  
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Fecal-oral route   a route of disease transmission, where pathogens in fecal material pass from one person and are introduced into the oral cavity of another person  
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Fever   an abnormally high body temperature that is usually caused by a bacterial or viral infection  
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Fomite   an inanimate object that carries disease organisms  
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Heavy chain   the larger polypeptide in an antibody molecule  
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Helper T cell   A T-lymphocyte that enhances the activity of B-lymphocytes and stimulates destruction of macrophages infected with bacteria  
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Host   an organism infected by a pathogen  
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Hyaluronidase   an enzyme that digests hyaluronic acid and thereby permits the penetration of pathogens through connective tissue  
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Incubation period   the time that elapses between the entry of a pathogen into the host and the appearance of signs and symptoms  
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Indirect contact   the mode of disease transmission involving nonliving objects  
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Infection   The invasion and multiplication of microorganisms such as bacteria, viruses, and parasites that are not normally present within the body  
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Infectious dose   the number of microorganisms needed to bring about infection  
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Inflammation   a nonspecific defense response to injury; usually characterized by redness, warmth, swelling and pain  
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Interferon   an antiviral protein produced by body cells upon exposure to viruses  
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Invasiveness   the ability of a pathogen to spread from one point to adjacent areas in the host and cause structural damage to those tissues  
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Light chain   a smaller polypeptide in an antibody  
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Lymphocyte   a type of white blood cell that functions in the immune system  
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Lysozyme   an enzyme found in tears and saliva that digests the peptidoglycan of gram-positive bacterial cell walls  
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Macrophage   a large cell derived from monocytes that is found within various tissues and actively engulfs foreign material  
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Mechanical vector   a living organisms, or object, that transmits disease agents on its surface  
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Memory B cell   a cell derived from B lymphocytes that reacts rapidly upon re-exposure to an antigen  
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Memory T cell   a cell derived from T lymphocytes that reacts rapidly upon re-exposure to an antigen  
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Mucus   a sticky secretion of viscous fluid  
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Mucous membrane   a moist lining in the body passages of all mammals that contains mucus-secreting cells and is directly or indirectly to the external environment  
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Mutualism   a close and permanent association between two populations if organisms in which both benefit from the association  
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Opportunistic   referring to pathogens that only cause disease when the person’s immune system is weakened  
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Outbreak   a small, localized epidemic  
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Pandemic   refers to a disease occurring over a wide geographic area (worldwide) and affecting a substantial proportion of the global population  
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Parasitism   a close association between two organisms in which one (the parasite) feeds on the other (the host) and may cause injury to the host  
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Passive immunity   the temporary immunity that comes from receiving antibodies from another source  
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Pathogenicity   the ability of a disease-causing agent to gain entry to a host and bring about a physiological or anatomical change interpreted as disease  
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Period of convalescence   the phase of disease during which the body’s systems return to normal  
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Period of decline   the phase of disease during which the symptoms subside  
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Phagocyte   a white blood cell capable of engulfing and destroying foreign materials or cells  
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Phagocytosis   a process by which foreign material or cells are taken into a white blood cell and destroyed  
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Plasma cell   an antibody-producing cell derived from B lymphocytes  
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Portal of entry   the site at which a pathogen enters the host  
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Portal of exit   the site at which a pathogen exits the host  
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Probiotic   living microbes that help reestablish or maintain the human microbiota of the gut  
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Prodromal phase   the phase of disease during which general symptoms occur in the body  
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Pyrogen   a fever producing substance  
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Reservoir   the location or organism where disease-causing agents exist and maintain their ability for infection  
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Serum   the fluid portion of the blood consisting of water, minerals, salts, proteins, and other organic substances including antibodies  
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Sign   a indication of the presence of a disease  
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Symbiosis   an interrelationship between two populations of organisms where there is a close permanent association  
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Symptom   an indication of some disease or other disorder that is experienced by the patient  
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Syndrome   a collection of signs or symptoms that together are characteristic of a disease  
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T lymphocyte   a type of white blood cell that matures in the thymus gland and is associated with cell-mediated immunity  
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Toxin   a poisonous chemical substance produced by an organism  
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Toxoid   a preparation of microbial toxin that has been rendered harmless by chemical treatment but that is capable of stimulating antibodies  
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Virulence   the degree to which a pathogen is capable of causing a disease  
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zoonosis   a disease spread from another animal to humans  
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