Microbio
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| Capsulated organisms work by ____ | show 🗑
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| show | S. aureus. Binds to Fc region of Ig, disrupting opsonization and phagocytosis.
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| show | Enzyme that cleaves IgA.
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| show | S. pneumoniae, H. influenzae, Neisseria
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| M protein. Secreted by ___. | show 🗑
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| show | Exotoxin= polypeptide, Endotoxin =LPS
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| show | Exotoxin=plasmid, bacteriophage, Endotoxin= bacterial chromosome
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| ____ has vaccine available only | show 🗑
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| Typical diseases with exotoxin | show 🗑
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| show | Meningococcemia, sepsis by gram negative bacteria
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| show | Superantigens bind directly to MHC II and T-cell receptor simultaneously, activating large numbers of T cells to stimulate release of IFN-gamma and IL-2.
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| Two bugs with superantigen toxins | show 🗑
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| Superantigen of S. aureus is called ____ and produces ___ with the symptoms of ____,____, ___. | show 🗑
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| S. aureus also produces enterotoxins that cause ___ and ____. | show 🗑
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| Superantigen of S. aureus is called ____ and produces ___ with the symptoms of ____,____, ___. | show 🗑
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| show | Food poisoning and exfoliatin (scalded skin syndrome)
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| Superantigen of S. aureus is called ____ and produces ___ with the symptoms of ____,____, ___. | show 🗑
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| S. aureus also produces enterotoxins that cause ___ and ____. | show 🗑
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| S. pyogenes produces a ____ exotoxin. This toxin is called ____ and produces ___. | show 🗑
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| ADP ribosylating A-B toxins work by ____. B functions by ___. A functions by ____. | show 🗑
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| 3 bugs that use ADP ribosylating A-B toxins are ____,____, ____, ____. | show 🗑
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| C. diptheriae produces an ___ type of exotoxin. It works by ___. It produces ____. | show 🗑
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| show | C. diptheriae
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| V. cholerae produces an ___ type of exotoxin. It works by ____. Produces ____. | show 🗑
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| E. coli produces an ___ type of exotoxin. It works by ____. Produces ____. | show 🗑
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| show | ADP-ribosylating toxin. It works by increasing cAMP by inhibiting Gi. Causes whooping caugh, inhibits chemokine receptor, causing lymphocytosis.
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| show | Alpha toxin. Causes gas gangrene. Get double zone of hemolysis on blood agar.
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| show | Blocks release of inhibitory neurotransmitters (GABA and glycine); causes lockjaw.
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| C. Botulinum produces an ___ type of exotoxin. it works by ___ and produces ____. | show 🗑
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| show | Edema factor type of adenylate cyclase
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| show | Shiga toxin (also produced by ETEC). Cleaves host cell rRNA (inactivates 60s); also enhances cytokine release. Causes HUS.
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| show | Streptolysin O is a hemolysin. antigen for ASO antibody which is used in diagnosis of rheumatic fever
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| show | V. cholerae, B. anthracis, E. coli (Heat labile), B. Pertussis
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| show | By activating Gs
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| show | By inactivating Gi (allowing cAMP to increase). Pertussis also promotes lymphocytosis by inhibiting chemokine receptors.
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| show | ABCDE. ShigA-like toxin, Botulinum toxin, Cholera toxin, Diptheria toxin, Erythorgenic toxin of S. pyogenes
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| What are organisms get resistance via transformation? | show 🗑
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| Lysogenic acquired toxins | show 🗑
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| Toxin is derived from a plasmid | show 🗑
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