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Microbio

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Question
Answer
Capsulated organisms work by ____   show
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show S. aureus. Binds to Fc region of Ig, disrupting opsonization and phagocytosis.  
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IgA protease   show
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show S. pneumoniae, H. influenzae, Neisseria  
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show Helps to prevent phagocytosis. Is secreted by streptococcal species.  
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Exotoxin made from ___, Endotoxin made from ____.   show
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show Exotoxin=plasmid, bacteriophage, Endotoxin= bacterial chromosome  
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____ has vaccine available only   show
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Typical diseases with exotoxin   show
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show Meningococcemia, sepsis by gram negative bacteria  
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show Superantigens bind directly to MHC II and T-cell receptor simultaneously, activating large numbers of T cells to stimulate release of IFN-gamma and IL-2.  
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show S. Aureus, S. pyogenes  
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Superantigen of S. aureus is called ____ and produces ___ with the symptoms of ____,____, ___.   show
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show Food poisoning and exfoliatin (scalded skin syndrome)  
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show TSST-1 (toxic shock syndrome) (fever, rash, shock)  
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S. aureus also produces enterotoxins that cause ___ and ____.   show
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show TSST-1 (toxic shock syndrome) (fever, rash, shock)  
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show Food poisoning and exfoliatin (scalded skin syndrome)  
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show Scarlet fever-erythrogenic toxin; causes toxic shock syndrome)  
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show Interfere with host cell function. B= binds to receptor on surface of host cell, enabling endocytosis. A (active) then attaches an ADP-ribosyl to a host cell protein, altering protein function.  
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show Corynebacterium diptheriae, Vibrio cholerae, E. Coli, Bordetella pertussis.  
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C. diptheriae produces an ___ type of exotoxin. It works by ___. It produces ____.   show
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Pseudomonas Exotoxin is similar to ____   show
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V. cholerae produces an ___ type of exotoxin. It works by ____. Produces ____.   show
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E. coli produces an ___ type of exotoxin. It works by ____. Produces ____.   show
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show ADP-ribosylating toxin. It works by increasing cAMP by inhibiting Gi. Causes whooping caugh, inhibits chemokine receptor, causing lymphocytosis.  
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show Alpha toxin. Causes gas gangrene. Get double zone of hemolysis on blood agar.  
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C. tetani produces an ___ type of exotoxin. it works by ___ and produces ____.   show
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show Blocks acetylcholine; causes anticholinergic symptoms, CNS paralysis, especially cranial nerves. (Spores found in food = floppy baby)  
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Bacillus anthracis produces an ___ type of exotoxin. it works by ___ and produces ____.   show
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show Shiga toxin (also produced by ETEC). Cleaves host cell rRNA (inactivates 60s); also enhances cytokine release. Causes HUS.  
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show Streptolysin O is a hemolysin. antigen for ASO antibody which is used in diagnosis of rheumatic fever  
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show V. cholerae, B. anthracis, E. coli (Heat labile), B. Pertussis  
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show By activating Gs  
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show By inactivating Gi (allowing cAMP to increase). Pertussis also promotes lymphocytosis by inhibiting chemokine receptors.  
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Genes for the following 5 bacterial toxins encoded by a lysogenic phage   show
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show S. pneumoniae, H. influenzae, Neisseria (Same as the ones that have the IgA)"Engineers get NHS grants and do major transformations"  
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show OBED (O- salmonella, Botulinum, erythrogenic toxin, Diptheria)  
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Toxin is derived from a plasmid   show
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