Microbio
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Capsulated organisms work by ____ | show 🗑
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show | S. aureus. Binds to Fc region of Ig, disrupting opsonization and phagocytosis.
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IgA protease | show 🗑
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show | S. pneumoniae, H. influenzae, Neisseria
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show | Helps to prevent phagocytosis. Is secreted by streptococcal species.
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Exotoxin made from ___, Endotoxin made from ____. | show 🗑
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show | Exotoxin=plasmid, bacteriophage, Endotoxin= bacterial chromosome
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____ has vaccine available only | show 🗑
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Typical diseases with exotoxin | show 🗑
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show | Meningococcemia, sepsis by gram negative bacteria
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show | Superantigens bind directly to MHC II and T-cell receptor simultaneously, activating large numbers of T cells to stimulate release of IFN-gamma and IL-2.
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show | S. Aureus, S. pyogenes
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Superantigen of S. aureus is called ____ and produces ___ with the symptoms of ____,____, ___. | show 🗑
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show | Food poisoning and exfoliatin (scalded skin syndrome)
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show | TSST-1 (toxic shock syndrome) (fever, rash, shock)
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S. aureus also produces enterotoxins that cause ___ and ____. | show 🗑
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show | TSST-1 (toxic shock syndrome) (fever, rash, shock)
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show | Food poisoning and exfoliatin (scalded skin syndrome)
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show | Scarlet fever-erythrogenic toxin; causes toxic shock syndrome)
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show | Interfere with host cell function. B= binds to receptor on surface of host cell, enabling endocytosis. A (active) then attaches an ADP-ribosyl to a host cell protein, altering protein function.
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show | Corynebacterium diptheriae, Vibrio cholerae, E. Coli, Bordetella pertussis.
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C. diptheriae produces an ___ type of exotoxin. It works by ___. It produces ____. | show 🗑
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Pseudomonas Exotoxin is similar to ____ | show 🗑
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V. cholerae produces an ___ type of exotoxin. It works by ____. Produces ____. | show 🗑
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E. coli produces an ___ type of exotoxin. It works by ____. Produces ____. | show 🗑
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show | ADP-ribosylating toxin. It works by increasing cAMP by inhibiting Gi. Causes whooping caugh, inhibits chemokine receptor, causing lymphocytosis.
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show | Alpha toxin. Causes gas gangrene. Get double zone of hemolysis on blood agar.
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C. tetani produces an ___ type of exotoxin. it works by ___ and produces ____. | show 🗑
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show | Blocks acetylcholine; causes anticholinergic symptoms, CNS paralysis, especially cranial nerves. (Spores found in food = floppy baby)
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Bacillus anthracis produces an ___ type of exotoxin. it works by ___ and produces ____. | show 🗑
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show | Shiga toxin (also produced by ETEC). Cleaves host cell rRNA (inactivates 60s); also enhances cytokine release. Causes HUS.
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show | Streptolysin O is a hemolysin. antigen for ASO antibody which is used in diagnosis of rheumatic fever
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show | V. cholerae, B. anthracis, E. coli (Heat labile), B. Pertussis
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show | By activating Gs
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show | By inactivating Gi (allowing cAMP to increase). Pertussis also promotes lymphocytosis by inhibiting chemokine receptors.
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Genes for the following 5 bacterial toxins encoded by a lysogenic phage | show 🗑
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show | S. pneumoniae, H. influenzae, Neisseria (Same as the ones that have the IgA)"Engineers get NHS grants and do major transformations"
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show | OBED (O- salmonella, Botulinum, erythrogenic toxin, Diptheria)
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Toxin is derived from a plasmid | show 🗑
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