Viruelence factors Test
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| A. ABCDE. ShigA-like toxin, Botulinum toxin, Cholera toxin, Diptheria toxin, Erythorgenic toxin of S. pyogenesB. TSST-1 (toxic shock syndrome) (fever, rash, shock)C. C. diptheriae produces an ADP-ribosylating A-B toxin. It works by inactivating (EF-2). It causes pharyngitis and "pseudomembrane" in throat.D. Heat labile = stimulates adenylate cyclase. Heat stable = stimulates guanylate cyclase. ADP-ribosylating AB toxin. Both cause watery diarrhea. "Labile like the Air, stable like the Ground".E. ADP-ribosylating AB toxin. It works by ADP ribosylating a G protein that stimulates adenylyl cyclase; this increases the Cl into the gut and decreases Na absorption. H20 moves into the gut and causes volumninous rice water diarrhea.F. S. Aureus, S. pyogenesG. ADP-ribosylating toxin. It works by increasing cAMP by inhibiting Gi. Causes whooping caugh, inhibits chemokine receptor, causing lymphocytosis.H. V. cholerae, B. anthracis, E. coli (Heat labile), B. PertussisI. S. aureus. Binds to Fc region of Ig, disrupting opsonization and phagocytosis.J. S. pneumoniae, H. influenzae, NeisseriaK. Exotoxin=plasmid, bacteriophage, Endotoxin= bacterial chromosomeL. S. pneumoniae, H. influenzae, Neisseria (Same as the ones that have the IgA)"Engineers get NHS grants and do major transformations"M. Exotoxin= polypeptide, Endotoxin =LPSN. Streptolysin O is a hemolysin. antigen for ASO antibody which is used in diagnosis of rheumatic feverO. Corynebacterium diptheriae, Vibrio cholerae, E. Coli, Bordetella pertussis.P. Blocks acetylcholine; causes anticholinergic symptoms, CNS paralysis, especially cranial nerves. (Spores found in food = floppy baby)Q. Scarlet fever-erythrogenic toxin; causes toxic shock syndrome)R. Blocks release of inhibitory neurotransmitters (GABA and glycine); causes lockjaw. S. Superantigens bind directly to MHC II and T-cell receptor simultaneously, activating large numbers of T cells to stimulate release of IFN-gamma and IL-2.T. Food poisoning and exfoliatin (scalded skin syndrome) |
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ddecampo
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