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Viruelence factors Test

Enter the letter for the matching Answer
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1.
E. coli produces an ___ type of exotoxin. It works by ____. Produces ____.
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2.
Typical diseases with exotoxin
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3.
What four bacteria induce cAMP
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4.
Two bugs with superantigen toxins
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5.
Superantigen of S. aureus is called ____ and produces ___ with the symptoms of ____,____, ___.
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6.
C. tetani produces an ___ type of exotoxin. it works by ___ and produces ____.
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7.
Bacillus anthracis produces an ___ type of exotoxin. it works by ___ and produces ____.
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8.
Location of genes for exotoxin, endotoxin
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9.
Protein A produced by _____.
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10.
S. pyogenes produces a ____ exotoxin. This toxin is called ____ and produces ___.
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11.
Clostridium perfringens produces an ___ type of exotoxin.
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12.
Typical diseases with endotoxin
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13.
S. Pyogenes produces produces an ___ type of exotoxin. it works by ___ and produces ____.
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14.
C. diptheriae produces an ___ type of exotoxin. It works by ___. It produces ____.
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15.
S. aureus also produces enterotoxins that cause ___ and ____.
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16.
C. Botulinum produces an ___ type of exotoxin. it works by ___ and produces ____.
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17.
Superantigens bind directly to ___ and ___. This activates ___ to release ___ and ___
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18.
3 bugs that use ADP ribosylating A-B toxins are ____,____, ____, ____.
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19.
Shigella produces an ___ type of exotoxin. it works by ___ and produces ____.
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20.
Genes for the following 5 bacterial toxins encoded by a lysogenic phage
A.
Scarlet fever-erythrogenic toxin; causes toxic shock syndrome)
B.
ABCDE. ShigA-like toxin, Botulinum toxin, Cholera toxin, Diptheria toxin, Erythorgenic toxin of S. pyogenes
C.
S. Aureus, S. pyogenes
D.
Heat labile = stimulates adenylate cyclase. Heat stable = stimulates guanylate cyclase. ADP-ribosylating AB toxin. Both cause watery diarrhea. "Labile like the Air, stable like the Ground".
E.
Corynebacterium diptheriae, Vibrio cholerae, E. Coli, Bordetella pertussis.
F.
Edema factor type of adenylate cyclase
G.
Food poisoning and exfoliatin (scalded skin syndrome)
H.
V. cholerae, B. anthracis, E. coli (Heat labile), B. Pertussis
I.
Shiga toxin (also produced by ETEC). Cleaves host cell rRNA (inactivates 60s); also enhances cytokine release. Causes HUS.
J.
S. aureus. Binds to Fc region of Ig, disrupting opsonization and phagocytosis.
K.
Blocks acetylcholine; causes anticholinergic symptoms, CNS paralysis, especially cranial nerves. (Spores found in food = floppy baby)
L.
C. diptheriae produces an ADP-ribosylating A-B toxin. It works by inactivating (EF-2). It causes pharyngitis and "pseudomembrane" in throat.
M.
Meningococcemia, sepsis by gram negative bacteria
N.
Streptolysin O is a hemolysin. antigen for ASO antibody which is used in diagnosis of rheumatic fever
O.
Alpha toxin. Causes gas gangrene. Get double zone of hemolysis on blood agar.
P.
Superantigens bind directly to MHC II and T-cell receptor simultaneously, activating large numbers of T cells to stimulate release of IFN-gamma and IL-2.
Q.
Blocks release of inhibitory neurotransmitters (GABA and glycine); causes lockjaw.
R.
TSST-1 (toxic shock syndrome) (fever, rash, shock)
S.
Exotoxin=plasmid, bacteriophage, Endotoxin= bacterial chromosome
T.
Tetanus, botulinism, diptheria
Type the Answer that corresponds to the displayed Question.
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21.
Pseudomonas Exotoxin is similar to ____
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22.
Toxin is derived from a plasmid
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23.
V. cholerae increases cAMP by ___.
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24.
____ has vaccine available only
Type the Question that corresponds to the displayed Answer.
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25.
OBED (O- salmonella, Botulinum, erythrogenic toxin, Diptheria)
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26.
Enzyme that cleaves IgA.

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