Chronic Lymphocytic Leukemia
Quiz yourself by thinking what should be in
each of the black spaces below before clicking
on it to display the answer.
Help!
|
|
||||
|---|---|---|---|---|---|
| Chronic lymphocytic leukemia (CLL)is caused by | clonal proliferation of B lymphocytes
🗑
|
||||
| Most patients with CLL are older than | 50 yearsof age
🗑
|
||||
| The most chronic leukemia is | Chronic Lymphocytic Leukemia (CLL)
🗑
|
||||
| Small lymphocytes begin to accumulate in the ____________ to a high degree and eventually spill into the peripheral blood. | spleen, lymph nodes, and bone marrow
🗑
|
||||
| In what percentage of patients do chromosomal abnormalities include chromosomes 11, 12, and 13? | 82%
🗑
|
||||
| What is associated with a poor prognosis in almost half of all patients with CLL? | Trisomy 12
🗑
|
||||
| Symptoms of CLL are | fatigue, pallor, weight lose, and lymphadenopathy
🗑
|
||||
| What is the most common of CLL | Lymphadenopathy
🗑
|
||||
| WBCs | greater than 100 x 10^9/L
🗑
|
||||
| M:E ratio | 10:1 or 20:1
🗑
|
||||
| Peripheral smear for CLL shows | small lymphocytes intermixed with few lymphoblasts and smudge cells may be present
🗑
|
||||
| What are smudge cells? | pieces of lymphocyte chromatin splashed across the smear
🗑
|
||||
| What develops in the course of CLL? | Anemia, thrombocytopenia, and neutropenia
🗑
|
||||
| Altered immune function of lymphocytes may lead to complications of.... | autoimmune hemolytic anemia (AIHA)
🗑
|
||||
| What are early indicators of the autoimmune hemolytic process? | Spherocytes and nRBCs
🗑
|
||||
| In 80% of CLL cases an ______ gene (BCL2) is present. | antiapoptosis
🗑
|
||||
| What are treatments of CLL? | Irradiation, fludarabine, alkylating agents, monoclonal antibodies, and allogenic stem cell transplant
🗑
|
||||
| The immunologic function of lymphocytes is compromised, with more than 50% of patients showing | hypogammaglobulinemia
🗑
|
||||
| Erythroid hyperplasia is present in the _____. | BM
🗑
|
||||
| The direct antiglobulin test, which measures antibody coating of the RBCs is _____. | positive
🗑
|
Review the information in the table. When you are ready to quiz yourself you can hide individual columns or the entire table. Then you can click on the empty cells to reveal the answer. Try to recall what will be displayed before clicking the empty cell.
To hide a column, click on the column name.
To hide the entire table, click on the "Hide All" button.
You may also shuffle the rows of the table by clicking on the "Shuffle" button.
Or sort by any of the columns using the down arrow next to any column heading.
If you know all the data on any row, you can temporarily remove it by tapping the trash can to the right of the row.
To hide a column, click on the column name.
To hide the entire table, click on the "Hide All" button.
You may also shuffle the rows of the table by clicking on the "Shuffle" button.
Or sort by any of the columns using the down arrow next to any column heading.
If you know all the data on any row, you can temporarily remove it by tapping the trash can to the right of the row.
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.
Normal Size Small Size show me how
Normal Size Small Size show me how
Created by:
sarah_sanderlin
Popular Laboratory Science sets