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CLL
Chronic Lymphocytic Leukemia
Question | Answer |
---|---|
Chronic lymphocytic leukemia (CLL)is caused by | clonal proliferation of B lymphocytes |
Most patients with CLL are older than | 50 yearsof age |
The most chronic leukemia is | Chronic Lymphocytic Leukemia (CLL) |
Small lymphocytes begin to accumulate in the ____________ to a high degree and eventually spill into the peripheral blood. | spleen, lymph nodes, and bone marrow |
In what percentage of patients do chromosomal abnormalities include chromosomes 11, 12, and 13? | 82% |
What is associated with a poor prognosis in almost half of all patients with CLL? | Trisomy 12 |
Symptoms of CLL are | fatigue, pallor, weight lose, and lymphadenopathy |
What is the most common of CLL | Lymphadenopathy |
WBCs | greater than 100 x 10^9/L |
M:E ratio | 10:1 or 20:1 |
Peripheral smear for CLL shows | small lymphocytes intermixed with few lymphoblasts and smudge cells may be present |
What are smudge cells? | pieces of lymphocyte chromatin splashed across the smear |
What develops in the course of CLL? | Anemia, thrombocytopenia, and neutropenia |
Altered immune function of lymphocytes may lead to complications of.... | autoimmune hemolytic anemia (AIHA) |
What are early indicators of the autoimmune hemolytic process? | Spherocytes and nRBCs |
In 80% of CLL cases an ______ gene (BCL2) is present. | antiapoptosis |
What are treatments of CLL? | Irradiation, fludarabine, alkylating agents, monoclonal antibodies, and allogenic stem cell transplant |
The immunologic function of lymphocytes is compromised, with more than 50% of patients showing | hypogammaglobulinemia |
Erythroid hyperplasia is present in the _____. | BM |
The direct antiglobulin test, which measures antibody coating of the RBCs is _____. | positive |