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Chronic Lymphocytic Leukemia

Chronic lymphocytic leukemia (CLL)is caused by clonal proliferation of B lymphocytes
Most patients with CLL are older than 50 yearsof age
The most chronic leukemia is Chronic Lymphocytic Leukemia (CLL)
Small lymphocytes begin to accumulate in the ____________ to a high degree and eventually spill into the peripheral blood. spleen, lymph nodes, and bone marrow
In what percentage of patients do chromosomal abnormalities include chromosomes 11, 12, and 13? 82%
What is associated with a poor prognosis in almost half of all patients with CLL? Trisomy 12
Symptoms of CLL are fatigue, pallor, weight lose, and lymphadenopathy
What is the most common of CLL Lymphadenopathy
WBCs greater than 100 x 10^9/L
M:E ratio 10:1 or 20:1
Peripheral smear for CLL shows small lymphocytes intermixed with few lymphoblasts and smudge cells may be present
What are smudge cells? pieces of lymphocyte chromatin splashed across the smear
What develops in the course of CLL? Anemia, thrombocytopenia, and neutropenia
Altered immune function of lymphocytes may lead to complications of.... autoimmune hemolytic anemia (AIHA)
What are early indicators of the autoimmune hemolytic process? Spherocytes and nRBCs
In 80% of CLL cases an ______ gene (BCL2) is present. antiapoptosis
What are treatments of CLL? Irradiation, fludarabine, alkylating agents, monoclonal antibodies, and allogenic stem cell transplant
The immunologic function of lymphocytes is compromised, with more than 50% of patients showing hypogammaglobulinemia
Erythroid hyperplasia is present in the _____. BM
The direct antiglobulin test, which measures antibody coating of the RBCs is _____. positive
Created by: sarah_sanderlin