SB82 Immunology - Loosely taken from Fiser's ABSITE review Chp4 on Immunology
Quiz yourself by thinking what should be in
each of the black spaces below before clicking
on it to display the answer.
Help!
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| Antigen that marks all T cells | CD3
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| B cells mature into this cell type | Plasma cell
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| What cytokine causes B cells to mature into plasma cells? | IL-4
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| What cytokine causes T cells to mature into cytotoxic T cells? | IL-2
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| What cytokines are released by Th1 cells? | IL-2 and IFN-gamma
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| Th2 cells release this cytokine | IL-4
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| CD8 antigen found on cytotoxic T cells recognize what substances? | Non-self antigens on MHC-1 receptors
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| What cell type recognizes viral antigens? | Cytotoxic T cells
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| What cell type recognizes intracellular pathogens? | Cytotoxic T cells
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| What happens when cytotoxic T cells detect an MHC-I presented non-self antigen? | It causes the presenting cells to undergo lysis/apoptosis
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| MHC class I is found on which cell types? | All nucleated cells and platelets
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| MHC class II is found on which cell types? | B cells, dendritic cells, monocytes, all APCs
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| Natural killer cells recognize this cell type | Cells that lack self-MHC
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| NK cells are part of the _______________ (innate vs. acquired) immune system | Innate
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| The variable regions of immunoglobulins are involved in this process | Antigen recognition
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| The constant regions of immunoglobulins are recognized by these cell types | PMNs and macrophages
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| Which antibodies fix complement? | IgM and IgG
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| Which antibody crosses the placenta during pregnancy? | IgG
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| Which antibody is found in Peyer’s patches? | IgA
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| What cell type is the major source of histamine in the blood? | Basophils
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| What cell type is the major source of histamine in tissue? | Mast cells
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| These two common tumor associated antigens are involved in liver cancer and colon cancer | AFP and CEA
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| IL-2 converts lymphocytes to this cell type active in the immune response to this situation | Lymphokine-activated killer cells help with the immune response to tumor (infiltration)
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| IFN-gamma upregulates what molecules? | MHC I and II
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| TNF-alpha is released by what cell type? | Cytotoxic T cells
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| TNF-alpha causes what response in target cells? | Lysis
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| TGF-beta is a growth factor for what cell type? | Epithelial cells
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| TGF-beta is released by many tumor cells, and causes suppression of what immune cell types? | Cytotoxic T cells and lymphokine-activated killer cells
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