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MEDT401 Ch. 8-11

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Term
Definition
Area under the curve (AUC)   Ratio of the FP rate to the TP rate produces a proportion AKA "under the curve". AUC of 0.50 (50%) means diagnostic test is no better than chance. AUC of 1.0 (100%) means diagnostic test is perfectly accurate.  
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Assessment   Collecting data w/which a diagnosis can be tested. Process is ID signs & symptoms of disease & recording the associated data for the purpose of informing a diagnosis. Assessment is not dx; it is a process of data collection an the collected data itself.  
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Audit trail   Record of decisions made through a naturalistic (qualitative study that can be referenced by a peer reviewer or an external auditor in assessing the trustworthiness of the study.  
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Blind   Procedure through which individuals (subjects, clinicians, and/or data analysts) are kept uninformed of the designation of subjects to study groups.  
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Cohen’s d   A statistic that shows effect size. A d score of 0.80 is considered a large effect. 0.20 is a small effect, 0.50 is a medium effect, I.I0 is a very large effect, and 1.40 or higher is an extremely large effect.  
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Cohen’s kappa   A statistic that shows inter-rater reliability for categorical data. A score of 0.80 or higher is generally considered an indication of a high level of consistency, meaning the data are reliable.  
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Complete history   Process for collecting information about a patient designed to elucidate a patient's entire health status. A complete history covers all body systems.  
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Computed tomography (CT)   A type of imaging procedure.  
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Constant comparative method   Interview data are analyzed after each participant's interview and the data from one interview are compared to the data from the other interviews; therefore. data collection and analysis occur simultaneously.  
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Correlation studies   Interview data are analyzed after each participant's interview and the data from one interview are compared to the data from the other interviews; therefore. data collection and analysis occur simultaneously.  
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Credibility   The degree to which data collection and interpretation are plausible. This concept is generally applied to naturalistic (qualitative) research.  
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Defensive medical practice   Excessive use of diagnostic procedures to avoid lawsuits by showing that every available measure was employed.  
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Dependability   The degree to which the interpretations in a naturalistic (qualitative) study are consistent with the data collected.  
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Differential diagnosis   Systematically comparing and contrasting results of diagnostic measures in order to determine which one of two or more diseases or conditions a patient is suffering from.  
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Dx   Diagnosis  
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Exclusion criteria   Characteristics (such as age, diagnosis. comorbidities, gender, etc.) that result in an individual being excluded from participating in a study. In many cases, exclusion criteria relate to risks of harm from the study intervention.  
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External validity   The degree to which the findings of the study are generalizable to the population and to a similar healthcare context.  
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Extraneous variables   Undesirable variables that interfere with the intended purpose of the investigation by introducing error to the study and affecting the dependent variable or outcome. AKA intervening variables.  
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Focused history   A process for collecting information about a patient designed to elucidate a specific problem and differentiate between critical and noncritical causes. A focused history covers only the relevant body systems.  
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Gold standard   The test that is known to be the most accurate, regardless of cost, invasiveness or other considerations.  
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Inclusion criteria   Characteristics (such as age, diagnosis, comorbidities, gender, etc.) that must be satisfied in order for an individual to be included in a study.  
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Institutional Review Board (IRB)   Organization reviews research proposals & regulates research activities. Can be internal or external & must be approved by the Office for Human Research Protections (OHRP), agency within the U.S. Department of Health & Human Services that oversees IRBs.  
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Intention-to-treat analysis   Procedure in which the data analyzed from a study include participants who completed at least one follow-up. The most rigorous approach is to utilize both per-protocol (on-protocol) and intent-to-treat and compare the results to see if they differ.  
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Internal validity   A characteristic of research design that relates to the degree to which the outcomes of the study can be attributed to the interventions.  
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Inter-rater reliability   Degree to which the data collected are consistent between different researchers. Measured via Cohen's Kappa test. Used in systematic reviews & meta-analyses to assess reviewer consistency in procedures for selecting & for critically appraising studies.  
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