blood bank guy notes practical
Quiz yourself by thinking what should be in
each of the black spaces below before clicking
on it to display the answer.
Help!
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| What types of RBCs should be issued with massive transfusion protocol? | O negative for young women. For males and postmenopausal females, it’s reasonable
to BEGIN by using O-positive blood in emergencies
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| List causes of warm autoimmune hemolytic anemia | 1) Idiopathic (~ 50%)
2) Malignancies (CLL, NHL) (~25%)
3) Autoimmune disease (SLE)
4) Drugs (α-methyldopa)
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| Triggers for Neonatal RBC Transfusions (Birth to 4 months) | Generally higher RBC transfusion thresholds than in
adults; common thresholds follow:
1) No symptoms: 8 g/dL
2) Cardiopulmonary disease, major surgery: 10 g/dL
3) Severe cardiopulmonary disease: 12-13 g/dL
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| Why is ABO compatibility more of a concern in neonatal platelet transfusions? | 1) Minor ABO mismatch that is ok in adult PLT
transfusions may be disastrous in neonates
2) Remember incompatible plasma and smaller baby
volumes; keep ABO compatible if at all possible
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| Describe the ASFA categories for therapeutic apheresis | a. Category I: TA accepted, proven for primary therapy
b. Category II: TA accepted, useful for 2
nd
-line therapy
c. Category III: TA not proven but might be helpful
d. Category IV: TA not helpful and may be harmful
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| Most common type of HDFN | ABO HDFN
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| Why are ABO HDFN generally mild or undiagnosed? | 1) Weak ABO antigen expression in utero
2) Soluble plasma ABO antigens neutralize antibodies
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| Describe blood types of ABO HDFN | Group O moms, group A or B babies
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| Obstetric indications for Rhogam | a) D-neg female at about 28 weeks gestation
b) D-neg female < 72 hours of D+ infant’s birth
c) D-neg female with pregnancy complications or
invasive procedures (amnio, cordocentesis)
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| How much blood does a full dose of Rhogam cover? | One full dose vial (300 g or 1500 IU) per 30
ml of D+ whole blood (15 ml D+ RBCs)
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| Why is HDFN particularly severe with anti-K? | Anti-K attaches to K antigen on early RBC precursors
and causes severe fetal anemia
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