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handbook TQs

Quiz yourself by thinking what should be in each of the black spaces below before clicking on it to display the answer.
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Question
Answer
Syngeneic HPCs are collected from this source   identical twin  
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Describe graft versus tumor effect in HPC transplantation   T lymphocytes in the donor unit attack residual tumor cells in the recipient  
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The primary complication of allogeneic HPC transplantation   Graft Versus Host Disease  
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Anatomic site of collection for most allogeneic marrow HPC transplants   iliac crests  
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Approximate volume of marrow collected for transplant   1 L  
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Cryopreservative used in storage of frozen HPC units   DMSO (dimethylsulfoxide)  
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For major ABO incompatible HPC products, this is removed   RBCs  
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For minor ABO incompatible HPC products, this is removed   plasma  
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Serious medical complications occur in __% of marrow donors   1%  
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Common side effects of DMSO include   garlic breath, nausea, vomiting, diarrhea, chill, and hypertension  
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Storage temperature for HPC marrow   room or refrigerated  
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Blood count abnormality sometimes associated with G-CSF   thrombocytopenia  
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The safe maximum dose per kg body wieight of DMSO is___ mL/kg/day   1mL/kg/day  
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Which takes longer to engraft: A. Allogeneic HPC, pheresis B. Allogeneic HPC, marrow C. HPC, cord blood   C. HPC, cord blood  
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Why are nonmyeloablative HPC transplants performed?   1. To enhance Graft versus leukemia effect 2. to minimize transplant related morbidity and mortality 3. permits transplantation of older patients 4. also used in non-malignant conditions  
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Before an HPC transplant, cellular blood products should be leukoreduced to reduce the risk of:   1. HLA alloimmunization 2. CMV transmission 3. Febrile reactions  
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definition of WBC engraftment after BMT   absolute neutrophil count >0.5×10(9)/L in the first  
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definition of platelet engraftment after BMT   platelet count >20×10(9)/L in the first 7 of consecutive days without transfusion support, respectively  
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