handbook TQs
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| Syngeneic HPCs are collected from this source | identical twin
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| Describe graft versus tumor effect in HPC transplantation | T lymphocytes in the donor unit attack residual tumor cells in the recipient
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| The primary complication of allogeneic HPC transplantation | Graft Versus Host Disease
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| Anatomic site of collection for most allogeneic marrow HPC transplants | iliac crests
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| Approximate volume of marrow collected for transplant | 1 L
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| Cryopreservative used in storage of frozen HPC units | DMSO (dimethylsulfoxide)
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| For major ABO incompatible HPC products, this is removed | RBCs
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| For minor ABO incompatible HPC products, this is removed | plasma
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| Serious medical complications occur in __% of marrow donors | 1%
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| Common side effects of DMSO include | garlic breath, nausea, vomiting, diarrhea, chill, and hypertension
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| Storage temperature for HPC marrow | room or refrigerated
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| Blood count abnormality sometimes associated with G-CSF | thrombocytopenia
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| The safe maximum dose per kg body wieight of DMSO is___ mL/kg/day | 1mL/kg/day
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| Which takes longer to engraft: A. Allogeneic HPC, pheresis B. Allogeneic HPC, marrow C. HPC, cord blood | C. HPC, cord blood
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| Why are nonmyeloablative HPC transplants performed? | 1. To enhance Graft versus leukemia effect
2. to minimize transplant related morbidity and mortality
3. permits transplantation of older patients
4. also used in non-malignant conditions
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| Before an HPC transplant, cellular blood products should be leukoreduced to reduce the risk of: | 1. HLA alloimmunization
2. CMV transmission
3. Febrile reactions
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| definition of WBC engraftment after BMT | absolute neutrophil count >0.5×10(9)/L in the first
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| definition of platelet engraftment after BMT | platelet count >20×10(9)/L in the first 7 of consecutive days without transfusion support, respectively
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