Kell blood group
Quiz yourself by thinking what should be in
each of the black spaces below before clicking
on it to display the answer.
Help!
|
|
||||
|---|---|---|---|---|---|
| true or false: Antibodies that target Kell antigens can cause transfusion reactions and hemolytic disease of the newborn (HDN). | True
🗑
|
||||
| What are the 3 most common blood group antigens that cause Hemolytic Disease of Newborn? | ABO, Rh incompatibility and Kell.
🗑
|
||||
| Why are cases of Hemolytic Disease of Newborn caused by Kell immunization so severe? | Cases of HDN caused by Kell immunization tend to result in severe fetal anemia because maternal anti-Kell target fetal RBC precursors, suppressing fetal production of RBCs
🗑
|
||||
| most clinically significant Kell antigen | K
🗑
|
||||
| Function of the Kell antigen | Kell glycoprotein is a transmembrane, single-pass protein that carries Kell antigens. It is an endothelin-3-converting enzyme; it cleaves "big" endothelin-3 to produce an active form that is a potent vasoconstrictor
🗑
|
||||
| Antigen frequency for K by race | K antigen: 2% in Blacks, 9% in Caucasians
🗑
|
||||
| Antibodies produced against Kell antigens are this isotype | IgG
🗑
|
||||
| Describe Antibody reactivity of antibodies to Kell antigens | Does not bind complement
If hemolysis does occur, it is extravascular in nature
🗑
|
||||
| Which Kell antibodies cause the most severe hemolytic transfusion reactions? | Anti-K and anti-Ku are capable of causing a severe reaction. A milder reaction is caused by anti-k, anti-Kpa, anti-Kpb, anti-Jsa, and anti-Jsb.
🗑
|
Review the information in the table. When you are ready to quiz yourself you can hide individual columns or the entire table. Then you can click on the empty cells to reveal the answer. Try to recall what will be displayed before clicking the empty cell.
To hide a column, click on the column name.
To hide the entire table, click on the "Hide All" button.
You may also shuffle the rows of the table by clicking on the "Shuffle" button.
Or sort by any of the columns using the down arrow next to any column heading.
If you know all the data on any row, you can temporarily remove it by tapping the trash can to the right of the row.
To hide a column, click on the column name.
To hide the entire table, click on the "Hide All" button.
You may also shuffle the rows of the table by clicking on the "Shuffle" button.
Or sort by any of the columns using the down arrow next to any column heading.
If you know all the data on any row, you can temporarily remove it by tapping the trash can to the right of the row.
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.
Normal Size Small Size show me how
Normal Size Small Size show me how
Created by:
jfshikle
Popular Laboratory Science sets