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Kell blood group

true or false: Antibodies that target Kell antigens can cause transfusion reactions and hemolytic disease of the newborn (HDN). True
What are the 3 most common blood group antigens that cause Hemolytic Disease of Newborn? ABO, Rh incompatibility and Kell.
Why are cases of Hemolytic Disease of Newborn caused by Kell immunization so severe? Cases of HDN caused by Kell immunization tend to result in severe fetal anemia because maternal anti-Kell target fetal RBC precursors, suppressing fetal production of RBCs
most clinically significant Kell antigen K
Function of the Kell antigen Kell glycoprotein is a transmembrane, single-pass protein that carries Kell antigens. It is an endothelin-3-converting enzyme; it cleaves "big" endothelin-3 to produce an active form that is a potent vasoconstrictor
Antigen frequency for K by race K antigen: 2% in Blacks, 9% in Caucasians
Antibodies produced against Kell antigens are this isotype IgG
Describe Antibody reactivity of antibodies to Kell antigens Does not bind complement If hemolysis does occur, it is extravascular in nature
Which Kell antibodies cause the most severe hemolytic transfusion reactions? Anti-K and anti-Ku are capable of causing a severe reaction. A milder reaction is caused by anti-k, anti-Kpa, anti-Kpb, anti-Jsa, and anti-Jsb.
Created by: jfshikle



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