Different coagulation testing methodologies and Factor Information
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| What laboratory evaluation of platelets does the following describe: Utilizes Platelet aggregometer, platelet rich plasma(37degC), and is stirred with a small magnetic bar to allow more light to pass through the suspension? | Aggregation Studies(principal in determing Primary Hemostasis)
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| Name the lab eval of platelets from the following hints: Congenital or Aquired D/O and assesses In-Vivo platelet function. | Bleeding Time
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| Can a periphial blood smear be used for aggregation studies of platelets? | Yes
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| What are the Factors involved in the Intrinsic Pathway Activation? | XII , XI , IX , VIII
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| What is the Factor involved in the Extrinsic Pathway Activation? | VII
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| What are the Factors involved in the Common Pathway Activation? | X , V , II , I
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| Name the Factors in the Fibrinogen group? | I, V , VIII , XIII
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| Name the Factors in the Prothrombin group? | II , VII , IX , X
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| Name the Factors in the Contact group? | XI, XII , HMWK , PK
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| What Factor group is Vitamin K dependent? | Prothrombin Group
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| Which Factor group is completely consumed in the coagulation process? | Fibrinogen Group
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| What Factor is consumed in the Prothrombin group during coagulation? | Factor II
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| What Factor group is not being synthesized during HDN? | Prothrombin Group
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| Limited Vit K storage and Vit K production is an indicator of what? | Immature liver
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| What is the treatment for HDN? | Vit K
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| During FDP test, latex particles in glycerine buffer are coated with __________ to human fibrinogen fragments: Frag ____ and Frag _____. | Specific Ab, D , E
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| Presence of FDP's in either serum or urine will cause latex particles to _______, yielding _____________ _____________. | clump, macroscopic agglutination
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| The latex particles provided in the D-Dimer Assay are coated with _______ anti-_______ D-dimer monoclonal bodies. | mouse, human
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| Test sample containing D-dimer when mixed with latex particle suspension make the particles __________. | agglutinate
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| Positive D-Dimer assay may be seen in clinical situations where active _________ is occuring such as DIC, DVT, and primary embolism. | thrombosis
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| Plasmin is formed in the absence of coagulation taking place describes what disorder? | Primary Fibrinolysis
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| Results from hypofibrinogenemic state induced by the proteolytic cleavage of fibrinogen by excess plasmin, in addition to the catabolic effect of the enzyme factors V and VIII. | Secondary Fibrinolysis
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| What are the three naturally occuring anti-coagulants? | Anti-thrombin III,Nat. Occuring Heparin, and Protein C & S (cofactor)
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| Name 3 aquired anti-coagulants? | Lupus Anticoagulant, Heparin, and Coumarin/warfarin
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| Coumarin/warfarin interferes with the recycling of what vitamin? | K
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| What test monitors coumarin/warfarin therapy? | PTT
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| Heparin acts to accelerate the rate of _________ by binding the serine protease, irreversibly inhibiting its activity. | anti-thrombin III
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| What test is used to monitor heparin therapy? | aPTT
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| Name the common laboratory screening tests for hemostatic D/O's? | PLT count, Periphial Smear, PTT, aPTT, TT, Bleeding Time.
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| What anticoagulant should be used in specimen collection? | sodium citrate
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| PT measures what factors? | I, II, V, X, VII (prothrombin group, due to the need of vitamin K)
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| PT helps to measure early Vitamin ___ deficiences. | K
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| Ref. Range for PT is ___ - ____ seconds. | 10 - 13
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| aPTT evaluates the _______ pathway of coagulation. | intrinsic
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| The purpose of the aPTT is to screen for _________ in the intrinsic pathway. | inhibitors
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| The aPTT is clinically significant due to its ability to screen/detect circulating _________. | Anticoagulants
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| The ref. range for aPTT is ______ - ________ seconds. | 25-35 seconds
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| Mixing studies are a diagnostic evaluation of unexplained prolonged ______ and ______ tests. | aPTT and PT
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| Mixing studies will only be performed when _________. | requested by a health care provider.
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| Mixing studies use commercially prepared ________ ___________ __________. | pooled normal plasma
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| What test evaluates the time required for thrombin to convert fibrinogen to an insoluble fibrin clot? | TT
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| The normal value time range should be ____ to _____ seconds. | 10 - 15
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| what buffer is used when quantitatively measuring fibrinogen? | owren's veronal buffer (pH 7.35)
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| Normal value range for fibrinogen is _______ to ________ mg/dL. | 200-400
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| What is the test used to screen for platelet dysfunction, testing mainly for primary hemostasis and platelet function. | BT
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| Name the 3 BT methods? | Ivy, Duke, and Mielke
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| what is the normal clotting time when performing the ivy testing method? | 0-8 minutes.
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| Bernard Souliers Syndrome will show abnormal _______ and _________ during aggregation studies. | Thrombin and Ristocetin
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| Glanzmann's thrombasthenia is a deficiency in glycoprotein contents, all aggregation studies will show abnormal except for ________. | Ristocetin
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| Decreased production of prostacyclin is a key indicator of the secondary condition due to drugs or infx is ________________ | Thrombotic Thrombocytopenic purpura
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| Acute blood loss, vigorous exercise, splenectomy, and hematopoiesis can all lead to _________ ___________. | reactive thrombosis
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| Adenocarcinoma, sepsis, and liver disease is most often accompanied by what secondary condition? | DIC
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