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Coagulation Studies
Different coagulation testing methodologies and Factor Information
| Question | Answer |
|---|---|
| What laboratory evaluation of platelets does the following describe: Utilizes Platelet aggregometer, platelet rich plasma(37degC), and is stirred with a small magnetic bar to allow more light to pass through the suspension? | Aggregation Studies(principal in determing Primary Hemostasis) |
| Name the lab eval of platelets from the following hints: Congenital or Aquired D/O and assesses In-Vivo platelet function. | Bleeding Time |
| Can a periphial blood smear be used for aggregation studies of platelets? | Yes |
| What are the Factors involved in the Intrinsic Pathway Activation? | XII , XI , IX , VIII |
| What is the Factor involved in the Extrinsic Pathway Activation? | VII |
| What are the Factors involved in the Common Pathway Activation? | X , V , II , I |
| Name the Factors in the Fibrinogen group? | I, V , VIII , XIII |
| Name the Factors in the Prothrombin group? | II , VII , IX , X |
| Name the Factors in the Contact group? | XI, XII , HMWK , PK |
| What Factor group is Vitamin K dependent? | Prothrombin Group |
| Which Factor group is completely consumed in the coagulation process? | Fibrinogen Group |
| What Factor is consumed in the Prothrombin group during coagulation? | Factor II |
| What Factor group is not being synthesized during HDN? | Prothrombin Group |
| Limited Vit K storage and Vit K production is an indicator of what? | Immature liver |
| What is the treatment for HDN? | Vit K |
| During FDP test, latex particles in glycerine buffer are coated with __________ to human fibrinogen fragments: Frag ____ and Frag _____. | Specific Ab, D , E |
| Presence of FDP's in either serum or urine will cause latex particles to _______, yielding _____________ _____________. | clump, macroscopic agglutination |
| The latex particles provided in the D-Dimer Assay are coated with _______ anti-_______ D-dimer monoclonal bodies. | mouse, human |
| Test sample containing D-dimer when mixed with latex particle suspension make the particles __________. | agglutinate |
| Positive D-Dimer assay may be seen in clinical situations where active _________ is occuring such as DIC, DVT, and primary embolism. | thrombosis |
| Plasmin is formed in the absence of coagulation taking place describes what disorder? | Primary Fibrinolysis |
| Results from hypofibrinogenemic state induced by the proteolytic cleavage of fibrinogen by excess plasmin, in addition to the catabolic effect of the enzyme factors V and VIII. | Secondary Fibrinolysis |
| What are the three naturally occuring anti-coagulants? | Anti-thrombin III,Nat. Occuring Heparin, and Protein C & S (cofactor) |
| Name 3 aquired anti-coagulants? | Lupus Anticoagulant, Heparin, and Coumarin/warfarin |
| Coumarin/warfarin interferes with the recycling of what vitamin? | K |
| What test monitors coumarin/warfarin therapy? | PTT |
| Heparin acts to accelerate the rate of _________ by binding the serine protease, irreversibly inhibiting its activity. | anti-thrombin III |
| What test is used to monitor heparin therapy? | aPTT |
| Name the common laboratory screening tests for hemostatic D/O's? | PLT count, Periphial Smear, PTT, aPTT, TT, Bleeding Time. |
| What anticoagulant should be used in specimen collection? | sodium citrate |
| PT measures what factors? | I, II, V, X, VII (prothrombin group, due to the need of vitamin K) |
| PT helps to measure early Vitamin ___ deficiences. | K |
| Ref. Range for PT is ___ - ____ seconds. | 10 - 13 |
| aPTT evaluates the _______ pathway of coagulation. | intrinsic |
| The purpose of the aPTT is to screen for _________ in the intrinsic pathway. | inhibitors |
| The aPTT is clinically significant due to its ability to screen/detect circulating _________. | Anticoagulants |
| The ref. range for aPTT is ______ - ________ seconds. | 25-35 seconds |
| Mixing studies are a diagnostic evaluation of unexplained prolonged ______ and ______ tests. | aPTT and PT |
| Mixing studies will only be performed when _________. | requested by a health care provider. |
| Mixing studies use commercially prepared ________ ___________ __________. | pooled normal plasma |
| What test evaluates the time required for thrombin to convert fibrinogen to an insoluble fibrin clot? | TT |
| The normal value time range should be ____ to _____ seconds. | 10 - 15 |
| what buffer is used when quantitatively measuring fibrinogen? | owren's veronal buffer (pH 7.35) |
| Normal value range for fibrinogen is _______ to ________ mg/dL. | 200-400 |
| What is the test used to screen for platelet dysfunction, testing mainly for primary hemostasis and platelet function. | BT |
| Name the 3 BT methods? | Ivy, Duke, and Mielke |
| what is the normal clotting time when performing the ivy testing method? | 0-8 minutes. |
| Bernard Souliers Syndrome will show abnormal _______ and _________ during aggregation studies. | Thrombin and Ristocetin |
| Glanzmann's thrombasthenia is a deficiency in glycoprotein contents, all aggregation studies will show abnormal except for ________. | Ristocetin |
| Decreased production of prostacyclin is a key indicator of the secondary condition due to drugs or infx is ________________ | Thrombotic Thrombocytopenic purpura |
| Acute blood loss, vigorous exercise, splenectomy, and hematopoiesis can all lead to _________ ___________. | reactive thrombosis |
| Adenocarcinoma, sepsis, and liver disease is most often accompanied by what secondary condition? | DIC |
Created by:
HM2 La Croix
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