Test 1 - Chapters 2-4,9,15
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each of the black spaces below before clicking
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| What is the average M:E ratio for normal adult bone marrow? | 4:1
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| The key organs involved in extramedullary hematopoiesis include the: | Liver and spleen
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| What assay is the best test to assess the bone marrow's response to anemic stress? | Reticulocyte count
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| A peripheral blood smear indicator of ineffective bone marrow response to anemia is: | A lack of polychromasia
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| A patient with the following values-- RBC = 4.01 x 10^12/L, Hgb = 12.5 g/dL, and Hct = 37.2% -- will most likely have which of the following RBC indices? | MCV=92.8 fL, MCH=31.2 pg, MCHC=33.6%
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| A patient's hemoglobin is 12.3 g/dL. On the peripheral smear, the red cells appear normochromic, normocytic. The hematocrit value that correlates with these data is: | 37%
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| A Wright-stained smear of a patient with an elevated reticulocyte count should show: | Polychromasia
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| Erythropoietin is produced by the: | Kidneys
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| Bone marrow aspiration is usually required in conditions of: | Leukemia
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| Mature red blood cells leave the bone marrow and enter the circulation via the: | Bone marrow sinuses
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| Correlation checks between the red blood cell count, the hemoglobin, and the hematocrit are significant parts of QA (quality assurance) in the hematology lab. These correlations are known as: | The rule of three
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| The _____ is one of the most stable parameters in a CBC. | MCV
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| The erythrocyte stage that marks the beginning of hemoglobinization is called: | Polychromatophilic normoblast
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| The red cell protein that is responsible for deformability and flexibility of the red cell is: | Spectrin
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| What RBC pathways is responsible for providing 90% of the cellular ATP for red cell metabolism? | Embden-Meyerhof pathway
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| The basic pathophysiology of the thalassemic conditions is a: | Decreased or absent globin chain synthesis
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| Polychromatophilic macrocytes in the peripheral smear are most likely: | Siderocytes
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| The degree of effective erythropoietic activity in any hematological disorder is most readily assessed by a: | Reticulocyte count
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| Most hypochromic cells will have an MCHC that is: | Less than 30%
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| The last nucleated stage of erythrocytic maturation is the: | orthochromic normoblast
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| From each pronormoblast precursor cell, ____ mature red blood cells are produced. | 16
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| Pappenheimer bodies are composed of: | Iron
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| What percentage of hemoglobin is synthesized in the reticulocyte stage? | 35%
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| Epsilon and zeta chains are part of which hemoglobins? | Hemoglobin Portland
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| Fetal hemoglobin consists of which of the following chains? | a2y2
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| What abnormal hemoglobins will result in a cyanotic condition? | Hemoglobin M
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| What factors will result in an immediate increase in oxygen delivery to the tissues? | Increased 2,3-DPG
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| What clinical conditions is a definitive sign of intravascular lysis? | Hemoglobinuria
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| Each hemoglobin molecule consists of ____ heme structures. | four
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| When iron is present in an oxidized state, as Fe+3 or ferric iron, the resulting hemoglobin is known as: | Methemoglobin
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| Intrinsic red cell defects that can lead to hemolysis include: | Inherited deficiencies
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| Lymphocyte concentrations in peripheral blood are greatest during what age interval? | Young child (1 to 4 years)
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| The CBC results for a 3-month-old child are as follows: WBC 9.5 x 10^9/L Differential RBC 3.4 x 10^12/L Seg neutrophils 25% Hgb 6.7 g/dL Lymphocytes 75% Hct 25% | The absolute lymphocyte count in this patient would be:
7.1 x 10^9/L
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| One of the primary glands responsible for lymphocyte origination in the infant is the: | Thymus gland
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| The initial appearance of specific granulation in the granulocytic series is predominantly seen in the: | myelocyte
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| In automated hematology, what is the definition of the delta check? | Comparison to previous value
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| There are _____ maturation stages in the neutrophil | Five
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| At present, most lymphocyte subpopulations are recognized by their CD markers. CD refers to: | Cluster designation
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| T cells are responsible for humoral immunity. | False
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| Patients with moderate anemias (7 to 10 g/dL) may be asymptomatic. | True
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| Hemoglobin begins to be synthesized at the polychromatophilic stage of red cell development. | True
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| 90% of in vivo hemolysis is intravascular. | False
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| The absolute WBC count refers to the percentage of a particular cell type counted from the 100 WBC differential. | True
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Created by:
Megan Hohenberg
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