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Hematology 1
Test 1 - Chapters 2-4,9,15
| Question | Answer |
|---|---|
| What is the average M:E ratio for normal adult bone marrow? | 4:1 |
| The key organs involved in extramedullary hematopoiesis include the: | Liver and spleen |
| What assay is the best test to assess the bone marrow's response to anemic stress? | Reticulocyte count |
| A peripheral blood smear indicator of ineffective bone marrow response to anemia is: | A lack of polychromasia |
| A patient with the following values-- RBC = 4.01 x 10^12/L, Hgb = 12.5 g/dL, and Hct = 37.2% -- will most likely have which of the following RBC indices? | MCV=92.8 fL, MCH=31.2 pg, MCHC=33.6% |
| A patient's hemoglobin is 12.3 g/dL. On the peripheral smear, the red cells appear normochromic, normocytic. The hematocrit value that correlates with these data is: | 37% |
| A Wright-stained smear of a patient with an elevated reticulocyte count should show: | Polychromasia |
| Erythropoietin is produced by the: | Kidneys |
| Bone marrow aspiration is usually required in conditions of: | Leukemia |
| Mature red blood cells leave the bone marrow and enter the circulation via the: | Bone marrow sinuses |
| Correlation checks between the red blood cell count, the hemoglobin, and the hematocrit are significant parts of QA (quality assurance) in the hematology lab. These correlations are known as: | The rule of three |
| The _____ is one of the most stable parameters in a CBC. | MCV |
| The erythrocyte stage that marks the beginning of hemoglobinization is called: | Polychromatophilic normoblast |
| The red cell protein that is responsible for deformability and flexibility of the red cell is: | Spectrin |
| What RBC pathways is responsible for providing 90% of the cellular ATP for red cell metabolism? | Embden-Meyerhof pathway |
| The basic pathophysiology of the thalassemic conditions is a: | Decreased or absent globin chain synthesis |
| Polychromatophilic macrocytes in the peripheral smear are most likely: | Siderocytes |
| The degree of effective erythropoietic activity in any hematological disorder is most readily assessed by a: | Reticulocyte count |
| Most hypochromic cells will have an MCHC that is: | Less than 30% |
| The last nucleated stage of erythrocytic maturation is the: | orthochromic normoblast |
| From each pronormoblast precursor cell, ____ mature red blood cells are produced. | 16 |
| Pappenheimer bodies are composed of: | Iron |
| What percentage of hemoglobin is synthesized in the reticulocyte stage? | 35% |
| Epsilon and zeta chains are part of which hemoglobins? | Hemoglobin Portland |
| Fetal hemoglobin consists of which of the following chains? | a2y2 |
| What abnormal hemoglobins will result in a cyanotic condition? | Hemoglobin M |
| What factors will result in an immediate increase in oxygen delivery to the tissues? | Increased 2,3-DPG |
| What clinical conditions is a definitive sign of intravascular lysis? | Hemoglobinuria |
| Each hemoglobin molecule consists of ____ heme structures. | four |
| When iron is present in an oxidized state, as Fe+3 or ferric iron, the resulting hemoglobin is known as: | Methemoglobin |
| Intrinsic red cell defects that can lead to hemolysis include: | Inherited deficiencies |
| Lymphocyte concentrations in peripheral blood are greatest during what age interval? | Young child (1 to 4 years) |
| The CBC results for a 3-month-old child are as follows: WBC 9.5 x 10^9/L Differential RBC 3.4 x 10^12/L Seg neutrophils 25% Hgb 6.7 g/dL Lymphocytes 75% Hct 25% | The absolute lymphocyte count in this patient would be: 7.1 x 10^9/L |
| One of the primary glands responsible for lymphocyte origination in the infant is the: | Thymus gland |
| The initial appearance of specific granulation in the granulocytic series is predominantly seen in the: | myelocyte |
| In automated hematology, what is the definition of the delta check? | Comparison to previous value |
| There are _____ maturation stages in the neutrophil | Five |
| At present, most lymphocyte subpopulations are recognized by their CD markers. CD refers to: | Cluster designation |
| T cells are responsible for humoral immunity. | False |
| Patients with moderate anemias (7 to 10 g/dL) may be asymptomatic. | True |
| Hemoglobin begins to be synthesized at the polychromatophilic stage of red cell development. | True |
| 90% of in vivo hemolysis is intravascular. | False |
| The absolute WBC count refers to the percentage of a particular cell type counted from the 100 WBC differential. | True |
Created by:
Megan Hohenberg
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