Hematology in Practice - Chapter 6
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| An appropriate M:E ratio in the case of megaloblastic anemia would be: | 1:3
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| A key substance required for the incorporation of vitamin B12 in red cell nuclear synthesis is the presence of: | Intrinsic factor
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| All of the following are true about intrinsic factor (IF): | Partial gastrectomy may lead to the lack of IF, 56% of patients with pernicious anemia have antibodies to IF, and atrophic gastritis may lead to the lack of IF.
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| Not true about intrinsic factor (IF): | Kidney failure may lead to lack of IF
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| What morphological features is classic in the megaloblastic anemias? | Macroovalocytes
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| Ineffective erythropoiesis is defined as: | Premature destruction of red cell precursors
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| One of the most common pathophysiologies that contribute to folic acid defieciency is: | Tropical sprue
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| The schilling test continues to be a historic reference method for the determination of: | Pernicious anemia
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| What is typically a macrocytic anemia? | folate deficiency
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| What lab results would suggest macrocytosis? | MCV = 108
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| Megaloblastic anemia causes a: | macrocytic, normochromic anemia
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| B12 and Folate are necessary for the synthesis of: | thymidine
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| What is the mechanism of Pernicious anemia? | Autoimmune disorder that destroys the intrinsic factor producing cells of the stomach
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| What group would have an increased need for folate? | Adolescents undergoing puberty
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| Lab findings common for Megaloblastic anemia include all of the following: | pancytopenia, increased MCV, and nuclear-cytoplasmic asynchrony
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| Finding not found in the lab with megaloblastic anemia: | schistocytes
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| Megaloblastic anemias results in cells that are: | macrocytic, normochromic
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| In a megaloblastic anemia, what result would be expected for a blilirubin test? | Increased
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| What bone marrow changes are most prominent in the megaloblastic anemias? | Asynchrony in the red blood cell precursors
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| What morphologic changes in the peripheral smear are markers for megaloblastic anemias? | Oval macrocytes and hypersegmented neutrophils
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| What is the most common vitamin deficiency in the United States? | Folic acid
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| What group of symptoms is particular to patients with megaloblastic anemia? | Difficulty in walking and mental confusion
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| What substance is necessary for vitamin B12 to be absorbed? | Intrinsic factor
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| What clinical finding is indicative of intramedullary hemolysis in megaloblastic processes? | Increased LDH
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| What adequately describes the pathophysiology of the megaloblastic anemias? | Lack of DNA synthesis
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| What morphologic feature is classic in the megaloblastic red cell precursors? | Asynchrony
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| A macrocytosis that is not megaloblastic in origin can be seen in all of the following except: A. Chemotherapy B. Postsplenectomy C. Thyroid conditions D. Reticulocytosis | C. Thyroid conditions
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| Ineffective erythropoiesis is defined as: | Premature destruction of red blood cell precursors
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Created by:
Megan Hohenberg
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