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Hematology 1
Hematology in Practice - Chapter 6
| Question | Answer |
|---|---|
| An appropriate M:E ratio in the case of megaloblastic anemia would be: | 1:3 |
| A key substance required for the incorporation of vitamin B12 in red cell nuclear synthesis is the presence of: | Intrinsic factor |
| All of the following are true about intrinsic factor (IF): | Partial gastrectomy may lead to the lack of IF, 56% of patients with pernicious anemia have antibodies to IF, and atrophic gastritis may lead to the lack of IF. |
| Not true about intrinsic factor (IF): | Kidney failure may lead to lack of IF |
| What morphological features is classic in the megaloblastic anemias? | Macroovalocytes |
| Ineffective erythropoiesis is defined as: | Premature destruction of red cell precursors |
| One of the most common pathophysiologies that contribute to folic acid defieciency is: | Tropical sprue |
| The schilling test continues to be a historic reference method for the determination of: | Pernicious anemia |
| What is typically a macrocytic anemia? | folate deficiency |
| What lab results would suggest macrocytosis? | MCV = 108 |
| Megaloblastic anemia causes a: | macrocytic, normochromic anemia |
| B12 and Folate are necessary for the synthesis of: | thymidine |
| What is the mechanism of Pernicious anemia? | Autoimmune disorder that destroys the intrinsic factor producing cells of the stomach |
| What group would have an increased need for folate? | Adolescents undergoing puberty |
| Lab findings common for Megaloblastic anemia include all of the following: | pancytopenia, increased MCV, and nuclear-cytoplasmic asynchrony |
| Finding not found in the lab with megaloblastic anemia: | schistocytes |
| Megaloblastic anemias results in cells that are: | macrocytic, normochromic |
| In a megaloblastic anemia, what result would be expected for a blilirubin test? | Increased |
| What bone marrow changes are most prominent in the megaloblastic anemias? | Asynchrony in the red blood cell precursors |
| What morphologic changes in the peripheral smear are markers for megaloblastic anemias? | Oval macrocytes and hypersegmented neutrophils |
| What is the most common vitamin deficiency in the United States? | Folic acid |
| What group of symptoms is particular to patients with megaloblastic anemia? | Difficulty in walking and mental confusion |
| What substance is necessary for vitamin B12 to be absorbed? | Intrinsic factor |
| What clinical finding is indicative of intramedullary hemolysis in megaloblastic processes? | Increased LDH |
| What adequately describes the pathophysiology of the megaloblastic anemias? | Lack of DNA synthesis |
| What morphologic feature is classic in the megaloblastic red cell precursors? | Asynchrony |
| A macrocytosis that is not megaloblastic in origin can be seen in all of the following except: A. Chemotherapy B. Postsplenectomy C. Thyroid conditions D. Reticulocytosis | C. Thyroid conditions |
| Ineffective erythropoiesis is defined as: | Premature destruction of red blood cell precursors |
Created by:
Megan Hohenberg
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