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Hematology 1

Hematology in Practice - Chapter 6

QuestionAnswer
An appropriate M:E ratio in the case of megaloblastic anemia would be: 1:3
A key substance required for the incorporation of vitamin B12 in red cell nuclear synthesis is the presence of: Intrinsic factor
All of the following are true about intrinsic factor (IF): Partial gastrectomy may lead to the lack of IF, 56% of patients with pernicious anemia have antibodies to IF, and atrophic gastritis may lead to the lack of IF.
Not true about intrinsic factor (IF): Kidney failure may lead to lack of IF
What morphological features is classic in the megaloblastic anemias? Macroovalocytes
Ineffective erythropoiesis is defined as: Premature destruction of red cell precursors
One of the most common pathophysiologies that contribute to folic acid defieciency is: Tropical sprue
The schilling test continues to be a historic reference method for the determination of: Pernicious anemia
What is typically a macrocytic anemia? folate deficiency
What lab results would suggest macrocytosis? MCV = 108
Megaloblastic anemia causes a: macrocytic, normochromic anemia
B12 and Folate are necessary for the synthesis of: thymidine
What is the mechanism of Pernicious anemia? Autoimmune disorder that destroys the intrinsic factor producing cells of the stomach
What group would have an increased need for folate? Adolescents undergoing puberty
Lab findings common for Megaloblastic anemia include all of the following: pancytopenia, increased MCV, and nuclear-cytoplasmic asynchrony
Finding not found in the lab with megaloblastic anemia: schistocytes
Megaloblastic anemias results in cells that are: macrocytic, normochromic
In a megaloblastic anemia, what result would be expected for a blilirubin test? Increased
What bone marrow changes are most prominent in the megaloblastic anemias? Asynchrony in the red blood cell precursors
What morphologic changes in the peripheral smear are markers for megaloblastic anemias? Oval macrocytes and hypersegmented neutrophils
What is the most common vitamin deficiency in the United States? Folic acid
What group of symptoms is particular to patients with megaloblastic anemia? Difficulty in walking and mental confusion
What substance is necessary for vitamin B12 to be absorbed? Intrinsic factor
What clinical finding is indicative of intramedullary hemolysis in megaloblastic processes? Increased LDH
What adequately describes the pathophysiology of the megaloblastic anemias? Lack of DNA synthesis
What morphologic feature is classic in the megaloblastic red cell precursors? Asynchrony
A macrocytosis that is not megaloblastic in origin can be seen in all of the following except: A. Chemotherapy B. Postsplenectomy C. Thyroid conditions D. Reticulocytosis C. Thyroid conditions
Ineffective erythropoiesis is defined as: Premature destruction of red blood cell precursors
Created by: Megan Hohenberg