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Stack #187405

Quiz yourself by thinking what should be in each of the black spaces below before clicking on it to display the answer.
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Question
Answer
which sulcus divides frontal and parietal lobes   central sulcus  
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brain is made up of   cerebellum, cerebrum, brain stem  
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purpose of having folding of cortex   pack as much neuroglial cell as possible  
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rostral is   anterior  
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caudal is   posterior  
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anterior also called   rostral  
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posterior also called   caudal  
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efferent leave spinal cord via   ventral root  
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afferent enter spinal cord via   dorsal root  
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soma of afferent sensory neuron located in   dorsal root ganglion  
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soma of efferent motor neuron located in   ventral horn  
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afferent and efferent neurons connected in the spinal cord by   interneurons  
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sensory receptor is ussually   cation channels  
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convergence of neuron   many neurons feeding into a single neuron  
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divergence of neuron   single neuron branching and feeding into many neurons  
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postsynaptic density is   sites on post synaptic neuron where receptors for neurotransmitters are located  
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sites on post synaptic neuron where receptors for neurotransmitters are located   postsynaptic density  
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most common excitatory neurotransmitter is   gluatmate  
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ACh binds to what   nicotinic receptor  
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nicotinic receptor function   Na+ Ca2+ in, K+ out => EPP (end plate potential) =>depolarization => AP  
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how many EPSP need to stimulate 1 muscle fiber   1  
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glutamatergic receptor causes   depolarization by letting Na+ in and K+ out  
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relationship between conductance and permeability   high permeability means high conductance  
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relationship between resistance and conductance   high conductance means low resistance  
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how many AP needed to generate an AP in muscle   1  
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GABA receptor causes   hyperpolarization by letting in Cl-  
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glycinergic causes   hyperpolarization by letting in Cl-  
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temporal summatoion   inputs from same presynaptic neurons  
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spatial summation   inputs from different presynatptic neurons  
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major excitatory trasmitter in CNS   glutamate  
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glutamate receptors   NMDA, AMPA, Kainate  
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too much glutamate released in CNS could cause   brain injury (stroke)  
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major cortical inhibitory trasmitter   GABA  
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GABA receptors   GABA(A), GABA(B)  
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GABA could cause   epilepsy  
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ACh receptors   nicotinic, muscarinic  
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ACh could cause   alzheimer  
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glycine receptors   glycine  
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glycine could cause   spasticity in spinal cord => cramps  
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major spinal inhibitory transmitter is   glycine  
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excitatory peptides are   substance p, TRH  
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inhibitory peptides are   endogenous, opioid  
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ionotropic receptor   binding of transmitter causes opening of the gate  
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metabotropic   binding of transmitter causes indirect opening of the gate via second messenger cascade  
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GPCR has how many subunits   7  
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effector ion channel in cAMP induced depolarization is   S-type K+ channel, the gate closes in response to getting phosphorylated by PKA  
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nicotinic metabotropic or ionotropic   ionotropic  
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muscarinic metabotropic or ionotropic   metabotropic  
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for ACh mediated EPSP fast EPSP due to   nicotinic channel  
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for ACh mediated EPSP slow EPSP due to   (muscarinic) M-type K+ channel being closed.  
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nicotine can bind to   only nicotinic receptor  
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muscarine can bind to   only muscarinic receptor  
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antagonist of nicotinic receptor   curare  
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curare   antagonist of nicotinic receptor  
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atropine   antagonist of muscarinic receptor  
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antagonist of muscarinic receptor   atropine  
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AMPA binds to   AMPA receptor  
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NMDA binds to   NMDA receptor  
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antagonist of AMPA receptor   CNQX  
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antagonist of NMDA receptor   APV  
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antagonist of Kainate receptor   CNQX  
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CNQX   antagonist of AMPA and kainate receptor  
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APV   antagonist of NMDA receptor  
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CNQX   antagonist of Kainate and AMPA receptor  
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NMDA can bind   glycine, glutamate, NMDA (paradox because here glycine is an excitatory transmitter)  
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NDMA receptor when activated causes   Ca2+ , Na+ in and K+ out => depol  
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AMPA receptor when activated causes   Na+ in, K+ out => depol  
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Kainate receptor when activated causes   Na+ in, K+ out  
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difference between NMDA and non-NMDA receptors   in non-NMDA, Ca2+ not involved.  
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which glutamate receptor is metabotropic and which is ionotropic   all ionotropic, except for glutamate induced G protein  
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axo-axonal synapse usually mediate   presynaptic inhibition  
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glutamate induced stimulation of G protein   activate PLC, PIP2 -> DAG + IP3, IP3 binds to IP3 receptor.  
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IP3 binding to IP3 receptor causes   release of Ca2+ into cytosol  
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GABA(A) ionotropic or metabotropic   ionotropic  
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GABA(B) ionotropic or metabotropic   metabotropic  
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GABA(A) causes (in axo-aoxonal synapse)   open Cl- channels.  
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GABA(B) causes (in axo-aoxonal synapse)   open K+ channels + block volt gated Ca2+ channels  
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endorphines excitatory or inhibitory   inhibitory, block afferent pain fiber by blocking Ca2+ channel or opening K+ channel  
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analgesia   axoaxonal inhibition which minimizes pain  
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different axons of skin in decreasing diameter   Aalpha, Abeta, Adelta, C  
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different axons of muscles in decreasing diameter   Group I, Group II, Group III, Group IV  
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information from spinal cord must pass through __ in order to get to the cortex   thalamus  
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somatosensory pathway for crude touch, pain or temperature   skin -> dorsal horn -> (synapse) -> cross over -> thalamus (2nd synapse) -> to cortex (diffuse projection)  
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relay nuclei for sensory inputs   thalamus  
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somatosensory pathway for fine touch, proprioception   skin -> pons (epsilateral side) -> (synapse) -> cross over -> thalamus -> (2nd synapse) -> to cortex (somatotopic projection)  
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gracilis   fibers from lower body  
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cuneatus   fibers from upper body  
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definition of diffuse projection and what somatosensory pathway it is found in   somatosensory neuron projects onto the cortex in a diffused manner (to non-specific region). found in path for pain or temperature.  
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definition of somatotopic projection and what somatosensory pathway it is found in   somatosensory neuron gets projected to a specific region in the cortex. found in path for fine touch, proprioception  
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pyramidal pathway is   pre-motor neuron taking info from motor cortex to spinal cord  
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MRI records activity of brain by   measuring the distribution and energy states of protons  
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positron emission tomography (PET)   measures neuronal activity in brain via an increased cerebral blood flow due to increased oxygen demand.  
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hearing words stimulates   temporal region  
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seeing words stimulates   occipital region  
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speaking words stimulates   the motor cortex on frontal  
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generating words stmimulates   frontal  
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in EEG(electroencephalogram), apical dendrites of pyramidal neurons receive inputs from   thalamus.  
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in EEG what is closer to the surface, apical dendrite or axon   apical dendrite  
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excitatory input from thalamus (eg. glutamate) causes   EPSP in apical dendrites  
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how is EEG measured?   by measuring change in voltage in extracellulr space in brain, in response to inputs from thalamus. (eg. excitatory input from thalamus => depol at apical dendrites => extracellular becomes negative)  
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negative EEG means   excitatory input from thalamus to pyramidal neuron  
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alpha rhythm during   relaxed state, preparing to go to sleep  
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beta rhythm during   alert  
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if a person is relaxed then you would see __ in EEG   alpha rhythm  
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a person has tumor so you would see __ in EEG   delta wave (delta wave also for sleeping infants)  
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if a person is alert then you would see __ in EEG   beta rhythm  
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part of limbic system involved in emootion   hippocampus  
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front part of hippocampus called   amygdala  
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