Biochem-SAM/B12/Folate-WVSOM Class of 2012
Quiz yourself by thinking what should be in
each of the black spaces below before clicking
on it to display the answer.
Help!
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| show | transfer of one methyl group to another molecule
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| folate has what molecule on the end? | show 🗑
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| show | no
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| show | dihydrofolate reductase (dhfr)
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| show | ingest->make monoglutamate->FH2->FH4
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| show | serine
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| show | purine and dtmp; serine; methylcobalamin
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| show | methylcobalamin
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| show | N5-methyl-FH4; transfers methyl group to B12
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| what is the other name for B12? why? what is important about cobalt? | show 🗑
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| B12 can only be synthesized how? | show 🗑
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| what are the 2 metabolites of B12? | show 🗑
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| show | Haptocorrin, Transcobalamin I, or R-binders
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| what is the process of B12 uptake to liver or tissue? | show 🗑
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| show | conversion of homocysteine to methionine; conversion of methylmalonyl-CoA to Succinyl CoA
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| show | adenosylcobalamin
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| Conversion of homocysteine to methionine requires what B12 form? | show 🗑
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| is methionine an essential amino acid? | show 🗑
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| what is most important function of SAM? | show 🗑
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| show | cardiovascular disease
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| what are 3 enzymatic causes of hyperhomocysteinemia? | show 🗑
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| PLP is derived from what vitamin? | show 🗑
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| how can homocysteine levels be reduced? | show 🗑
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| show | B12 and folate; reduced nucleotides leads to less cellular dividing
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| in addition to macrocytic anemia, what else can occur in B12 deficiency? why? | show 🗑
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| what is the methyl trap hypothesis? | show 🗑
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| show | intrinsic factor
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| show | pernicious anemia
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| show | reduced gastric secretions (IF) and inadequate diet
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| what explains how B12 affects dna replication? | show 🗑
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