Stack #176328
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| Testing | done on those suspected on basis of signs, symptoms or family history to have disease
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| Screening | done independent of signs, symptoms, or family history
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| mass screening | low false negative rate; follow-ups identify true positives and true negatives, inexpensive
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| Sensitivity | A/A+C percentage of affected actually affected
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| Specificity | D/B+D percentage of unaffected who are unaffected
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| To confirm results that may be false positives | confirm for genetic heterogeneity, biologic variation, error
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| Biochemical assays | comprehensive in covering multiple mutations in one gene or several genes in a metabolic pathway with a common endpoint
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| DNA mutation screens | Requires high frequency mutations with current technology
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| A primary goal of population screening is | to predict with high accuracy which individuals in a group are at significant risk of developing or transmitting a disease.
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| Once individuals at high risk for a disease are identified | confirmatory (diagnostic) tests are then performed to detect the screened-for disease with greater certainty
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| A screening test only indicates | who in a given population is most likely to be at higher risk for developing a disease.
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| A false positive occurs when a test | misidentifies individuals as being higher risk, when they are actually not at higher risk.
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| A false negative occurs when | individuals with a higher risk for the disorder are not identified by the screening test.
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| a diagnostic test is done following a positive screening test to determine | whether an individual has a disorder and thus rules out false positives. Diagnostic tests are typically more
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| Disease registries | a valuable epidemiological resource that can be used to calculate incidence rates and risks, as well as to maintain surveillance and monitor trends in incidence and mortality.
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Created by:
knpearso
Popular Genetics sets