STEP Study Cards for Platelet Function
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| Platelets are activated by- | collagen, thrombin, adp receptors (p2y1 & p2y12) expressed on platelets
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| Where are collagen, thrombin, and adp (p2y1&p2y12) expressed- | on platelets
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| Platelets are also known as- | thrombocytes
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| Platelets potentially modulate inflammatory processes by- | intercepting w/ leukocytes & secreting cytokines and chemokines
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| What helps to reinforce the platelet plug- | high concentration of myosin & actin
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| Normal platelet count for healthy adult- | 150,000-400,000 per mm of blood
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| The formation of fibrin strands woven through the plug & cross-linked to form a ___ ___ - | fibrin net
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| T or F The discovery of platelet dysfunction in a pt may not always be associated w/venous injury | true
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| Suggested indications for platelet function testing include the following: Pt who experiences easy bruising Women experiencing a menorrhgia (heavy menstrual bleeding) - - - | pre-op assessment
anti-platelet therapy monitoring
uremia (circulating substances impair platelet interactions w/the vessel wall)
cirrhosis (thrombocytopenia, coagulopathy, & vascular abnormality)
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| What test was used to evaluate platelet function by making a standard incision on the forearm & measuring the time required for bleeding to stop_ | bleeding time test
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| Why is BT being phased out of hospitals today- | not sensitive or specific,
doesn't reflect the risk or potential severity of a surgical bleed,
rarely reproducable,
easily affected by ingestion of aspirin or other meds
leaves a small scar
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| Microprocessor controlled instrumentation & disposable test cartridges use what blood sample- | whole citrated blood obtained from a single venipuncture
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| T or F Improved diagnostic value, PT acceptance & cost are reason enough to evaluate platelet function on new instrumentation over the use of the BT test | true
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| What was the first analyzer commercially available in-vitro test to measure platelet function | PFA-100
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| How much blood does the PFA-100 require | 800microliters of whole citrated blood
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| CT means | closure time
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| What does closure time mean | the time taken to occlude the flow
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| What is the primary test cartridge used to id mild to severe platelet dysfunction, von Willebrand factor deficiency or the effect of aspirin | the collagen-epinephrine cartridge
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| What does the VerifyNow Test, test for | GPIIb/GPIIIa dependent aggregation
aspirin effects
P2y12 blockade
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