Immunohematology
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| In humans, what organ is considered responsible for producing T lymphocytes? | Thymus
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| Cells that syntesize antibody are? | Mature B lymphocytes
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| Rejection of a transplant is characteristic of which of the immune response systems? | Cellular immune system
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| The secondary or anamnestic response causes proliferation of what antibodies? | IgG
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| The primary response causes proliferation of what antibodies? | IgM
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| Immunoglobulins are part of what type of immunity? | Humoral
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| Which lymphocytes are responsible for cellulare immunity, tissue graft rejection, delayed hypersensitivity reactions and immunloogic surveillance? | T lymphocytes
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| A low molecular-weight substance that rarely stimulates the production or antibodies, but can react with an antibody if present. | Hapten
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| When can hapten ilicit an immune response? | When attached to a carrier protein
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| An antigen that reacts with antibodies from within the same species. | Alloantigen
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| An antibody produced in response to an antigen possessed by the same individual. | Autoantibody
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| An antiboy produced in one species that reacts with an antigen from another species. | Heterophile antibody
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| What is another name for a Heterophile antibody? | xenoantibody
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| What immune antiboyd reacts best at 37C, resistant to treatment with sulfhydryl compounds, and often requires the addition of antihuman globulin to produce agglutination? | IgG
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| Which of the immune antibodies is the largest, arranged in a pentamer, and cannot cross the placental barrier? | IgM
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| Which immune antibody activates the complement cascade by way of the alternate pathway once aggregated? | IgA
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| Which immune antibody is a reaginic antibody that binds to mast cells by the Fc portion and is associated with immediate hypersensitivity? | IgE
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| How are the 5 classes of immunoglobulins distinguished? | By their amino acids in the constant region of their heavy classes.
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| Which phenomenon is due to excess of antibody in relation to antigen, preventing the formation of a lattice? | prozone due to antibody excess.
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| Which test for syphilis is primarily used for screening for the treponemal antibody; is sensitive but lacks specificity? | RPR
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| Which laboratory test is specific and is used for a comfirmatory test when testing for the treponemal antigen? | FTA-ABS
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| What substance is produced by the liver in inflammation, necrotic, and infectious diseases? | CRP
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| What type of test is the ASO test? | neutralization test
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| The antistreptolysin O present in a person with group A streptococcal infection, neutralizes the reagent streptolysin. What is the postive result going to show? | No lysis of the red blood cells.
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| Which blood group antibody is mainly IgM, reacts best at 4C, associated with atypical pneumonia, and cold autoimmune hemolytic anemia? | Anti-I
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| Which antigens should be tested for when assessing histocompatibility for organ transplantation, paternity testion, or for the selection of platelet and granulocyte donors? | HLA antigens
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| What is the minimum time interval for blood donation? | 8 weeks
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| The blood group that reacts LEAST strongly with anti-H lectin is? | A1B
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| The blood group that reacts the strongest with anti-H lectin is? | O
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| Which 2 antibodies are most often naturally occurring, react best at room temp., and can agglutinate cells in saline medium? | anti-M and anti-N
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| Which blood group system antigens are primarily in the plasma and adsorbed onto red cells. | Lewis
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| Which type of blood group cells are used for antibody screening tests? | Group O, Rh-pos
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| Why is it important that antiglobulin serum be added immediately after washing the cells? | Cell bound IgG may detach from the red cells if delayed addition.
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| A patient who has repeated severe nonhemolytic febrile transfusion reactions and requires transfusion of blood for oxygen-carryig capacity should be transfused with what type of blood product? | Leukocyte-Poor Red Blood Cells
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| What test is the best and quickest way to determine acute hemolysis in a transfusion reaction? | Direct antiglobulin test on the posttransfusion specimen
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| Which antibody is most often associated with delayed hemolytic transfusion reactions? | Jka
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| An acute hemolytic transfusion reaction is most commonly due to? | An ABO mismatch
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| What should be done with a donor unit that contains 37 degree C reacting antibodies? | Be processed into components that contain minimal amounts of plasma.
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| Whole blood collected in CPDA-1 may be stored for how many days? | 35 days
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| What is the only solution that can be added to blood or components before or during a transfusion? | Normal Saline.
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| The temperature of a refrigerator that contains stored blood should not exceed what temperature? | 6 degrees C
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| What is the term for average strength of binding between antigens and antibodies? | Avidity
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| What is the term for nonspecific attachment of substances to the surfaces of insoluble particles? | Adsorption
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| What is the term for the use of reagents to remove certain antigens from a mixture by serologic reaction? | Absorption
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| Allergic reaction to grass pollen is an example of which type of hypersensitivity reaction? | type I hypersensitivity reaction
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| Anaphylactic reactions that occur with in minutes and are mediated by IgE antibodies are consitered which type of hypersensitivity reaction? | Type I hypersensitivity reaction
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| Autoimmune hemolytic anemias and thrombocytopenic purpura are caused by antibodies directed against an individual's own red cells. Which type of hypersensitivity reaction is this? | Type II hypersensitivity reaction
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| Immune complexes are deposited in an individuals tissues in the diseases of Systemic lupus erythematosus and poststreptococcal glomerulonephritis. Which type of hypersensitivity reaction is this? | Type III hypersensitivity reaction.
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| During TB skin reaction and contact dermatitis, sensitized T cells release lymphkines following a secondary exposure to antigen. Which type of hypersensitivity reaction is this? | Type IV hypersensitivity reaction
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