MLT boards- heme and hemostasis
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| The hemorrhagic problems assiciated with scurvy are due to a deficiency of ____________, which is a cofactor required for collagen synthesis. | Vitamin C
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| approximately how many platelets dies an average megakaryocyte generate? | 2000
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| Thrombocytopenia may be caused by all the following EXCEPT a. post-splenectomy b. chemotherapy c. decreased theombopoietin d. aplastic anemia | a. post-splenectomy
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| During the hemostatic process, platelets interacting with ans binding to other platelets is referred to as | aggregation
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| In platelet aggregation studies, certain aggregating agents induce a biphasic aggregation curve. To what is the second phase of aggregation directly related? | release of endogenous ADP
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| What is the operating principle of a platelet aggregometer? | change in optical density: as platelets aggregate, the optical density of the platelet-rich plasma decreases
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| What platelet aggregation agent characteristically yields a biphasic pattern when used in optimal concentration? | epinephrine
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| Which therapeutic agent affects platelet function? | aspirin
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| Apotent inhibitor of platelet aggregation released by endothelial cells is | prostacyclin
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| what is the approximate normal mean platelet volume (MPV) expressed in femtoliters (fL)? | 10
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| The platelet parameter PCW refers to the | variation in cell size
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| What describes normal histograms showing platelet size distribution? | right-skewed, single peak
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| For the performance of manuel platelet counts, what is the recommended type of microscopy? | phase
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| 20uL of blood are diluted in 1.98mL of diluent. This dilution is plated on both sides of a Neubauer-ruled counting chamber. 356 cells are seen when both large center squares are counted. What is the platelet count expressed as the number of cells/liter? | 178 X 10^9/L
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| What size threshold range does the electrical impedance method use to count particules as platelets? | 2-20fL
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| In storage pool diseases, lpatelets are primarily deficient in | ADP
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| What is the specimen of choice for routine coagulation testing? | 3.2% (1.109M) sodium citrate
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| The ratio of anticoagulant to blood for coagulation procedures should be 1 to | 9.0
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| The liver is the site of synthesis of all the following EXCEPT a. Factor VIII b. Plasmingogen c. Protein C d. von Willebrand's factor | d. von Willebrand's factor
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| When thrombin binds with thrombomodulin on the endothelial cell surface, thrombin can | activate protein C
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| What is the coagulation fdactor that has a sex-linked recessive inheritance pattern? | factor IX
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| What is associated with individuals having a Prekallikrein deficiency? | can have thrombotic complications
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| A soybean extract is used in specimen collection tubes for fibrin degradation product (FDP) tests to prevent | further fibrinogen degradation
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| The thrombin time will be prolonged in the presence of | factor II deficiency
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